
Technologies, Journal Year: 2024, Volume and Issue: 12(10), P. 173 - 173
Published: Sept. 25, 2024
Electrospinning is a highly versatile and powerful technique that has transformed the field of nanotechnology [...]
Language: Английский
Technologies, Journal Year: 2024, Volume and Issue: 12(10), P. 173 - 173
Published: Sept. 25, 2024
Electrospinning is a highly versatile and powerful technique that has transformed the field of nanotechnology [...]
Language: Английский
Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(31), P. 14095 - 14140
Published: July 30, 2024
Abstract Electrospun nanofibers have gained prominence as a versatile material, with applications spanning tissue engineering, drug delivery, energy storage, filtration, sensors, and textiles. Their unique properties, including high surface area, permeability, tunable porosity, low basic weight, mechanical flexibility, alongside adjustable fiber diameter distribution modifiable wettability, make them highly desirable across diverse fields. However, optimizing the properties of electrospun to meet specific requirements has proven be challenging endeavor. The electrospinning process is inherently complex influenced by numerous variables, applied voltage, polymer concentration, solution flow rate, molecular weight polymer, needle-to-collector distance. This complexity often results in variations nanofibers, making it difficult achieve desired characteristics consistently. Traditional trial-and-error approaches parameter optimization been time-consuming costly, they lack precision necessary address these challenges effectively. In recent years, convergence materials science machine learning (ML) offered transformative approach electrospinning. By harnessing power ML algorithms, scientists researchers can navigate intricate space more efficiently, bypassing need for extensive experimentation. holds potential significantly reduce time resources invested producing wide range applications. Herein, we provide an in-depth analysis current work that leverages obtain target nanofibers. examining work, explore intersection ML, shedding light on advancements, challenges, future directions. comprehensive not only highlights processes but also provides valuable insights into evolving landscape, paving way innovative precisely engineered various Graphical abstract
Language: Английский
Citations
21Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 2, 2025
Abstract Electrospinning is increasingly used as a staple technology for the fabrication of nano‐ and micro‐fibers different materials. Most processes utilize direct current (DC) electrospinning, multitude DC‐electrospinning tools ranging from research to commercial production systems currently available. Yet, there are numerous studies performed on electrospinning techniques utilizing non‐DC, periodic electric fields, or alternating (AC) electrospinning. Those demonstrate strong potential AC‐electrospinning sustainable various nanofibrous materials structures. Although tremendous progress achieved in development over last 10 years, this technique remains uncommon. This paper reviews concepts, instrumentation, technology. The main focus review most studied, “electric wind” driven tentatively named field (AFES). latter term emphasizes role AC field's confinement fiber‐generating electrode absence counter such an system. synopses AFES process parameters, spinneret designs, benefits obstacles, advancements electrospun nano/micro‐fibrous materials/structures their applications given, future directions discussed.
Language: Английский
Citations
2Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 290 - 290
Published: Feb. 13, 2025
Gum Arabic (GA), or acacia gum, refers to the dried exudate produced by certain Acacia trees. GA is composed mainly of a mixture polysaccharides and glycoproteins, with proportions that can slightly differ from one species another. It commonly utilized in food pharmaceutical industries as stabilizer an emulsifier owing its biocompatibility, hydrophilicity, antibacterial properties. In addition, be manipulated it possesses many functional groups used grafting, cross-linking, chemical modifications add new feature developed material. this review, we highlight recent GA-based formulations, including nanoparticles, hydrogels, nanofibers, membranes, scaffolds, their possible applications tissue regeneration, cancer therapy, wound healing, biosensing, bioimaging, packaging, antimicrobial antifouling membranes.
Language: Английский
Citations
2Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12
Published: Feb. 27, 2025
Despite advancements in surgical techniques, many patients born with congenital heart defects (CHD) require repeated reinterventions due to the limitations of materials used cardiac surgery (CCS). Traditional biogenic polymers, such as bovine or equine pericardium, are prone calcification, have limited durability, and fail adapt growth infants. This study aims address these challenges by investigating bacterial cellulose (BC) a promising material for CCS. Variability patch quality from previous studies was addressed refining production protocol taking advantage optical density (OD) measurements. After 72 h incubation, patches were harvested tested mechanically burst pressure uniaxial strain testing. BC's biomechanical properties further explored modifying nutrient concentrations, creating different media groups (N10, N30, N50). Hybrid combining BC electrospun polyurethane (ESP-PU) developed using specially designed 3D-printed flask ensure uniform coating integration. The initial concentration significantly influenced yield rate, static cultures outperforming shaken ones. Nutrient-enriched N50) produced greater elasticity strength compared standard C-Medium, stiffness correlating concentration. Inflation tests showed that N10 N30 samples withstood higher pressures than N50, which, despite being stiffer, performed worse under rapid inflation. All samples, however, maintained above physiological levels. Scanning electron microscopy analysis confirmed effective PU fibres without altering fibre orientation activity. demonstrated resistance 1,400 mmHg. can be tailored, combination ESP-PU, an innovative hybrid produced, positioning biomaterial future CCS implant development.
Language: Английский
Citations
0BioTech, Journal Year: 2025, Volume and Issue: 14(1), P. 23 - 23
Published: March 19, 2025
Ischemic heart disease (IHD) is the leading cause of mortality worldwide, underscoring urgent need for innovative therapeutic strategies. The cardiac extracellular matrix (ECM) undergoes extreme transformations during IHD, adversely influencing heart's structure, mechanics, and cellular signaling. Researchers investigating regenerative capacity diseased have turned their attention to exploring modulation ECM improve outcomes. In this review, we thoroughly examine current state knowledge regarding its potential in ischemic myocardium. We begin by providing an overview fundamentals ECM, focusing on structural, functional, regulatory mechanisms that drive modulation. Subsequently, ECM's interactions within both chronically acutely infarcted myocardium, emphasizing key components roles modulating angiogenesis. Finally, discuss recent ECM-based approaches biomedical engineering, different types scaffolds as delivery tools compositions, conclude with future directions research. By harnessing these emerging therapies, aim contribute development novel modalities IHD.
Language: Английский
Citations
0International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142552 - 142552
Published: March 1, 2025
Language: Английский
Citations
0Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
ABSTRACT Electrospinning has been studied to deposit polylactic acid (PLA) nanofibers on complex coronary stent geometries. The rheological properties of PLA with two molecular weights were analyzed in various solvents, including chloroform, acetone, dichloromethane, and dimethylformamide, determine the entanglement concentration. High weight dissolved a 2:1 v/v chloroform: acetone was suitable form bead‐free uniform morphology. A response surface methodology implemented evaluate electrospinning parameters (concentration, flow rate, voltage). thin film mat examined by scanning electron microscopy (SEM) size fibers fiber diameter distribution. concentration 8% w/v, voltage 15 kV, rate 0.02 mL/min produced an average around 491 ± 150 nm flat surface. Additionally, deposited geometry using rotary motor, resulting measuring approximately 817 388 nm.
Language: Английский
Citations
0Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Abstract The incidence and burden of skin wounds, especially chronic complex have a profound impact on healthcare. Effective wound healing strategies require multidisciplinary approach, advances in materials science bioengineering paved the way for development novel dressing. In this context, electrospun nanofibers can mimic architecture natural extracellular matrix provide new opportunities healing. Inspired by bioelectric phenomena human body, nanofibrous scaffolds with electroactive characteristics are gaining widespread attention gradually emerging. To end, review first summarizes basic process healing, causes current status clinical treatment, highlighting urgency importance dressings. Then, biological effects electric fields, preparation materials, manufacturing techniques (EEN) discussed. latest progress EEN enhancing is systematically reviewed, mainly including treatment monitoring. Finally, scaffold to enhance emphasized, challenges prospects summarized.
Language: Английский
Citations
0Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Biomimetic cell membrane-coated nanofibers enhance tissue repair by reducing immune rejection and enabling targeted signaling, with applications in bone regeneration, vascular repair, cancer therapy.
Language: Английский
Citations
0Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(5)
Published: May 1, 2025
ABSTRACT Nanofiber‐based drug delivery systems show strong potential due to their high surface area‐to‐volume ratio and adjustable structure. Recent studies demonstrated loading efficiencies exceeding 85%, with sustained release kinetics up 96 h. In cancer models, nanofiber‐based carriers improved accumulation at tumor sites by 3–4 fold compared conventional formulations, enhancing therapeutic efficacy minimizing systemic toxicity. This review outlines methods for precise nanofiber shape function control through electrospinning solution blow spinning techniques. advancements in technology have proven promising biomedical applications where they are utilized tissue engineering, neurodegenerative disease management, wound healing, targeted therapy. Nanofibers as an optimal system that improves cellular restoration, together controlled deep penetration capabilities. The recent development of dual‐drug systems, stimuli‐responsive nanofibers, scaffolds composed nanofibers smart materials has expanded usage precision medicine. Research now demonstrates facilitate remodeling functions along angiogenesis promotion, inflammatory response stability improvement. also focuses on the patents a system. addition, this presents new approaches overcome these challenges based interdisciplinary cooperation, AI‐driven design such sophisticated bioinformatics tools. review, advances prospects realizing revolution field improving healthcare outcomes presented detailed overview.
Language: Английский
Citations
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