Intravital Imaging of Immune Responses in the Cancer Microenvironment DOI Creative Commons
Hiroki Hirao, Masaki Honda, Masahiro Tomita

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(8)

Published: April 1, 2025

ABSTRACT Background To date, many types of immune cells have been identified, but their precise role in cancer immunity remains unclear. Understanding the responses involved and microenvironment is becoming increasingly important for elucidating disease mechanisms. In recent years, application intravital imaging research has provided new insights into mechanisms cancer‐specific events, including innate adaptive immunity. Results this review, we focus on emerging describe how can be observed using vivo. We also discuss gained by state‐of‐the‐art technique. Conclusions Intravital a relatively field that offers significant advantages, ability to directly capture cell–cell interactions, pathophysiology, cell dynamics

Language: Английский

Emerging insights into intravital imaging, unraveling its role in cancer immunotherapy DOI Creative Commons
Minfeng Yang, Shiqiang Hou, Qianming Chen

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(3)

Published: Feb. 4, 2025

Cancer immunotherapy has attracted great attention as a potential therapeutic approach for advanced malignancies due to its promising survival benefits. Comprehension of intricate interactions between the tumor microenvironment (TME) and immune checkpoint inhibitors (ICIs) is crucial optimizing improving immunotherapies. Currently, several experimental strategies are available monitor this complexity but most them fail facilitate real-time monitoring response such cellular phagocytosis cytolysis. Consequently, application intravital imaging been extensively studied in domain cancer immunotherapy. Intravital proven be powerful modality that provides insights into intratumoral responses, metabolic signatures, vasculature, functions. This review aims provide comprehensive overview latest research on immunotherapy, especially addressing how sheds light essential features immunity, infiltrations, angiogenesis, aids clarification underlying immunotherapeutic mechanisms. Moreover, variety labeling tools, windows models visualizations TME also summarized. We will investigate full using circumvent limitations currently modalities, which hold promise advent efficient patients.

Language: Английский

Citations

1
Intravital Imaging of Immune Responses in the Cancer Microenvironment DOI Creative Commons
Hiroki Hirao, Masaki Honda, Masahiro Tomita

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(8)

Published: April 1, 2025

ABSTRACT Background To date, many types of immune cells have been identified, but their precise role in cancer immunity remains unclear. Understanding the responses involved and microenvironment is becoming increasingly important for elucidating disease mechanisms. In recent years, application intravital imaging research has provided new insights into mechanisms cancer‐specific events, including innate adaptive immunity. Results this review, we focus on emerging describe how can be observed using vivo. We also discuss gained by state‐of‐the‐art technique. Conclusions Intravital a relatively field that offers significant advantages, ability to directly capture cell–cell interactions, pathophysiology, cell dynamics

Language: Английский

Citations

0