Effects of concurrent optical and magnetic stimulation in hard-to-heal wounds: a real-world evidence case series DOI

J.C.L. Neyens,

Wilma van Heusden,

Dennis Van Veenendaal

et al.

Journal of Wound Care, Journal Year: 2024, Volume and Issue: 33(8), P. 560 - 568

Published: Aug. 2, 2024

Objective: This work explores concurrent optical and magnetic stimulation (COMS) effects on hard-to-heal wounds in real-world settings. Method: In this case series, participants received COMS 1–3 times per week for up to 12 weeks alongside standard wound care. Results: A total of 27 patients (18 female nine male) were included. Mean age was 72 years. Participants’ that unresponsive care included: venous leg ulcers (VLUs, n=13); mixed (MLUs, n=4); diabetic foot (DFUs, n=1); pressure (PUs, n=5); traumatic (TWs, n=4). On average, applied twice a week, resulting an overall mean area reduction 69%. 24 participants, used primarily achieve closure by the end 12-week period, which: classified as complete (50%; VLUs=8, PUs=3 TW=1); four likely-to-heal (17%; VLUs=2 MLUs=2); ‘improved’ MLU=1, DFU=1 TWs=2); ‘non-responding’ VLUs=3 MLU=1). The best results achieved PUs VLUs (respectively 100% 62% categorised completely healed). When where its purpose other than achieving closure, successfully debride two PUs, bed preparation one TW. Conclusion: showed positive appeared be beneficial healing different types community health homecare Novel therapy aspects emerged: (1) outcomes PU VLU treatment; (2) potential debridement tool when sharp is unfeasible; (3) promising method prepare beds subsequent skin grafting or replacement procedures.

Language: Английский

Are Aminoglycoside Antibiotics TRPing Your Metabolic Switches? DOI Creative Commons
Alfredo Franco‐Obregón, Yee Kit Tai

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1273 - 1273

Published: July 29, 2024

Transient receptor potential (TRP) channels are broadly implicated in the developmental programs of most tissues. Amongst these tissues, skeletal muscle and adipose noteworthy for being essential establishing systemic metabolic balance. TRP respond to environmental stimuli by supplying intracellular calcium that instigates enzymatic cascades consequence often impinge on mitochondrial function biogenesis. Critically, aminoglycoside antibiotics (AGAs) have been shown block capacity conduct entry into cell response a wide range biophysical nature, including mechanical, electromagnetic, thermal, chemical. Paradoxically, vitro paradigms commonly used understand organismal development may led astray conventional use streptomycin, an AGA, help prevent bacterial contamination. Accordingly, streptomycin has disrupt both vivo myogenesis, as well phenotypic switch white beige thermogenic status. In vivo, TRP-mediated calcium-dependent exercise adaptations importance metabolism. Alternatively, also curb detrimental levels leakage dystrophic through aberrantly gated TRPC1 be involved etiology X-linked muscular dystrophies. susceptible AGA antagonism critically modulating tissues that, if administered behaving animals, translate systemwide disruption. Regenerative medicine clinical communities need made aware this caveat usage seek viable alternatives, contamination or infection paradigms, respectively.

Language: Английский

Citations

2
Effects of concurrent optical and magnetic stimulation in hard-to-heal wounds: a real-world evidence case series DOI

J.C.L. Neyens,

Wilma van Heusden,

Dennis Van Veenendaal

et al.

Journal of Wound Care, Journal Year: 2024, Volume and Issue: 33(8), P. 560 - 568

Published: Aug. 2, 2024

Objective: This work explores concurrent optical and magnetic stimulation (COMS) effects on hard-to-heal wounds in real-world settings. Method: In this case series, participants received COMS 1–3 times per week for up to 12 weeks alongside standard wound care. Results: A total of 27 patients (18 female nine male) were included. Mean age was 72 years. Participants’ that unresponsive care included: venous leg ulcers (VLUs, n=13); mixed (MLUs, n=4); diabetic foot (DFUs, n=1); pressure (PUs, n=5); traumatic (TWs, n=4). On average, applied twice a week, resulting an overall mean area reduction 69%. 24 participants, used primarily achieve closure by the end 12-week period, which: classified as complete (50%; VLUs=8, PUs=3 TW=1); four likely-to-heal (17%; VLUs=2 MLUs=2); ‘improved’ MLU=1, DFU=1 TWs=2); ‘non-responding’ VLUs=3 MLU=1). The best results achieved PUs VLUs (respectively 100% 62% categorised completely healed). When where its purpose other than achieving closure, successfully debride two PUs, bed preparation one TW. Conclusion: showed positive appeared be beneficial healing different types community health homecare Novel therapy aspects emerged: (1) outcomes PU VLU treatment; (2) potential debridement tool when sharp is unfeasible; (3) promising method prepare beds subsequent skin grafting or replacement procedures.

Language: Английский

Citations

0