Advancements of paper-based microfluidics and organ-on-a-chip models in cosmetics hazards DOI Creative Commons
Sanidhya Pai,

A Binu,

G. S. Lavanya

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(13), P. 10319 - 10335

Published: Jan. 1, 2025

Different detection approaches for monitoring adulterants/hazards present in cosmetics using paper-based devices and organ-on-a-chip.

Language: Английский

Fabrication of Organ-on-a-Chip using Microfluidics DOI

S. Ying-Jin,

Iván Yuste, Elena González‐Burgos

et al.

Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00394 - e00394

Published: Jan. 1, 2025

Language: Английский

Citations

0
Treatment Response to Oncolytic Virus in Patient-Derived Breast Cancer and Hypopharyngeal Cancer Organoids: Evaluation via a Microfluidics Organ-on-a-Chip System DOI Creative Commons
Yu Sun,

Jiaqi Liu,

Li Zhu

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(2), P. 146 - 146

Published: Feb. 4, 2025

In this study, we present an oncolytic virus (OV) evaluation system established using microfluidic organ-on-a-chip (OOC) systems and patient-derived organoids (PDOs), which was used in the development of a novel virus, AD4-GHPE. An OV offers advantages such as good targeting ability minimal side effects, it has achieved significant breakthroughs when combined with immunotherapy recent clinical trials. The OVs become emerging research focus. PDOs can preserve heterogeneity situ tumor tissues, whereas OOC automate standardize various experimental procedures. These have been applied cutting-edge drug screening cell therapy experiments; however, their use functionally complex viruses remains to be explored. constructed recombinant adenovirus, AD4-GHPE, evaluated through functional validations hypopharyngeal breast cancer organoids. results confirmed that AD4-GHPE exhibits three antitumor mechanisms, namely, tumor-specific cytotoxicity, reduction programmed death ligand 1 (PD-L1) expression cells increase CD8+ T-cell activity, granulocyte–macrophage colony-stimulating factor (GM-CSF) secretion. combining efficient reliable, providing personalized treatment recommendations for patients offering industrialized standardized ideas OVs.

Language: Английский

Citations

0
Advancements of paper-based microfluidics and organ-on-a-chip models in cosmetics hazards DOI Creative Commons
Sanidhya Pai,

A Binu,

G. S. Lavanya

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(13), P. 10319 - 10335

Published: Jan. 1, 2025

Different detection approaches for monitoring adulterants/hazards present in cosmetics using paper-based devices and organ-on-a-chip.

Language: Английский

Citations

0