Importance of nanocomposites in 3D bioprinting: An overview DOI
K. Gomathi,

S. Sendilvelan,

Mohana Priya R

et al.

Bioprinting, Journal Year: 2023, Volume and Issue: 32, P. e00280 - e00280

Published: May 18, 2023

Language: Английский

In Vitro Cancer Models: A Closer Look at Limitations on Translation DOI Creative Commons

Nina Antunes,

Banani Kundu, Subhas C. Kundu

et al.

Bioengineering, Journal Year: 2022, Volume and Issue: 9(4), P. 166 - 166

Published: April 7, 2022

In vitro cancer models are envisioned as high-throughput screening platforms for potential new therapeutic discovery and/or validation. They also serve tools to achieve personalized treatment strategies or real-time monitoring of disease propagation, providing effective treatments patients. To battle the fatality metastatic cancers, development and commercialization predictive robust preclinical in urgent need. past decades, translation research from 2D 3D diverse have been well elaborated an enormous number reviews. However, meagre clinical success rate therapeutics urges critical introspection currently available platforms, including patents, hasten precision medicine models. Hence, present article critically reflects difficulty translating adoption light tools. The state art is discussed first, followed by identifying limitations bench-to-bedside transition. This review tries establish compatibility between current findings obstacles indicates future directions accelerate market penetration, considering niche market.

Language: Английский

Citations

21
Current Perspectives on Gastrointestinal Models to Assess Probiotic-Pathogen Interactions DOI Creative Commons
Mehreen Anjum, Arja Laitila, Arthur C. Ouwehand

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 31, 2022

There are different models available that mimic the human intestinal epithelium and thus for studying probiotic pathogen interactions in gastrointestinal tract. Although, vivo make it possible to study overall effects of a on living subject, they cannot always be conducted there is general commitment reduce use animal models. Hence, vitro methods provide more rapid tool interaction between probiotics pathogens; as well being ethically superior, faster, less expensive. The represented by complex traditional models, standard 2D compromised culture plates Transwell inserts, newer 3D like organoids, enteroids, organ-on-a-chip. optimal model selected depends research question. Properly designed and/or studies needed examine mechanism(s) action pathogens obtain physiologically relevant results.

Language: Английский

Citations

20
Advances in 3D culture systems for therapeutic discovery and development in brain cancer DOI
Janith Wanigasekara, Patrick J. Cullen, Paula Bourke

et al.

Drug Discovery Today, Journal Year: 2022, Volume and Issue: 28(2), P. 103426 - 103426

Published: Nov. 1, 2022

Language: Английский

Citations

20
Recent trends in antioxidative peptides derived from soybean and other soy-based products: A comprehensive review DOI

C. C. Kalita,

Unmesh Mehta,

Krishna Aayush

et al.

Process Biochemistry, Journal Year: 2023, Volume and Issue: 136, P. 311 - 323

Published: Dec. 6, 2023

Language: Английский

Citations

13
Importance of nanocomposites in 3D bioprinting: An overview DOI
K. Gomathi,

S. Sendilvelan,

Mohana Priya R

et al.

Bioprinting, Journal Year: 2023, Volume and Issue: 32, P. e00280 - e00280

Published: May 18, 2023

Language: Английский

Citations

12