Current Advances in Viral Nanoparticles for Biomedicine DOI

Xianxun Sun,

Tao Tian,

Yindong Lian

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Viral nanoparticles (VNPs) have emerged as crucial tools in the field of biomedicine. Leveraging their biological and physicochemical properties, VNPs exhibit significant advantages prevention, diagnosis, treatment human diseases. Through techniques such chemical bioconjugation, infusion, genetic engineering, encapsulation, these been endowed with multifunctional capabilities, including display functional peptides or proteins, encapsulation therapeutic drugs inorganic particles, integration imaging agents, conjugation bioactive molecules. This review provides an in-depth analysis biomedicine, elucidating diverse types, distinctive features, production methods, complex design principles behind VNPs. It highlights recent innovative research various applications, covering roles imaging, drug delivery, therapeutics, gene vaccines, immunotherapy, tissue regeneration. Additionally, assessment safety biocompatibility discusses challenges future opportunities field, underscoring vast potential evolving nature VNP research.

Language: Английский

Advances in Lung Cancer Treatment Using Nanomedicines DOI Creative Commons
Akshansh Sharma,

Devanshi Shambhwani,

Sadanand Pandey

et al.

ACS Omega, Journal Year: 2022, Volume and Issue: 8(1), P. 10 - 41

Published: Dec. 29, 2022

Carcinoma of the lungs is among most menacing forms malignancy and has a poor prognosis, with low overall survival rate due to delayed detection ineffectiveness conventional therapy. Therefore, drug delivery strategies that may overcome undesired damage healthy cells, boost therapeutic efficacy, act as imaging tools are currently gaining much attention. Advances in material science have resulted unique nanoscale-based theranostic agents, which provide renewed hope for patients suffering from lung cancer. Nanotechnology vastly modified upgraded existing techniques, focusing primarily on increasing bioavailability stability anti-cancer drugs. Nanocarrier-based systems treatment carcinoma proven possess considerable benefits, such early targeted effectively treating Several variants nano-drug agents been successfully studied applications, liposomes, dendrimers, polymeric nanoparticles, nanoemulsions, carbon nanotubes, gold magnetic solid lipid hydrogels, micelles. In this Review, we present comprehensive outline various types overexpressed receptors cancer, well targeting approaches nanoparticles.

Language: Английский

Citations

106
Nanomaterials-assisted photothermal therapy for breast cancer: State-of-the-art advances and future perspectives DOI Creative Commons
Sagnik Nag, Oishi Mitra, G. Tripathi

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 45, P. 103959 - 103959

Published: Jan. 21, 2024

Breast cancer (BC) remains an enigmatic fatal modality ubiquitously prevalent in different parts of the world. Contemporary medicines face severe challenges remediating and healing breast cancer. Due to its spatial specificity nominal invasive therapeutic regime, photothermal therapy (PTT) has attracted much scientific attention down lane. PTT utilizes a near-infrared (NIR) light source irradiate tumor target intravenously or non-invasively, which is converted into heat energy over optical fibre. Dynamic progress nanomaterial synthesis was achieved with specialized visual, physicochemical, biological, pharmacological features make up for inadequacies expand horizon PTT. Numerous nanomaterials have substantial NIR absorption can function as efficient transducers. It achievable limit wavelength range absorbance peak specific by manipulating their synthesis, enhancing precision quality Along same lines, various are conjugated wide surface-modifying chemicals, including polymers antibodies, may modify persistence diminish toxicity concerns. In this article, we tend put forth insights fundamental conceptualizations on pre-existing advances upon conjugation biocompatible working synergy combat cancer, encompassing several strategies like immunotherapy, chemotherapy, photodynamic therapy, radiotherapy coupled Additionally, role mechanisms nanoparticles, well possible alternatives PTT, summarized distinctive integral aspect article.

Language: Английский

Citations

56
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment DOI Creative Commons
Fatih Çiftçi, Ali Can Özarslan, İmran Cagri Kantarci

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 121 - 121

Published: Jan. 16, 2025

In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made effective drug design. Drug targeting aims ensure that acts only pathological area; it defined as ability accumulate selectively quantitatively target tissue or organ, regardless of chemical structure active substance method administration. With targeting, conventional, biotechnological gene-derived drugs body’s organs, tissues, cells can be transported specific regions. These systems serve carriers regulate timing release. Despite having many advantageous features, these have limitations thoroughly treating complex diseases such cancer. Therefore, combining with nanoparticle technologies imperative treat cancer at both local systemic levels effectively. The nanocarrier-based delivery involves encapsulating target-specific molecules into polymeric vesicular systems. Various (DDS) were investigated discussed this review article. first part passive systems, hydrogels, thermoplastics, microdevices transdermal-based second carrier nanobiotechnology (carbon nanotubes, nanoparticles, coated, pegylated, solid lipid nanoparticles smart nanogels). third part, advantages discussed, finally, market research commercial used nanotechnological approaches was included.

Language: Английский

Citations

2
Research trends on nanomaterials in gastric cancer: a bibliometric analysis from 2004 to 2023 DOI Creative Commons

Li‐Xiang Ling,

Yaobin Ouyang, Yi Hu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 2, 2023

Abstract Background Gastric cancer is one of the leading causes cancer-related deaths worldwide. In recent years, an increasing number studies aimed at designing and developing nanomaterials for use in diagnosing treating gastric have been conducted. this study, we to comprehensively assess current status trends research on application through a bibliometric analysis. Methods Studies focusing were retrieved from Web Science Core Collection database relevant articles selected inclusion study according criteria. Bibliometric visual analysis included publications was performed using VOSviewer CiteSpace. Results A total 793 included. An increase annual observed 2004 2023. China, Iran USA dominant countries field, accounting 66.1%, 11.5% 7.2% publications, respectively. Shanghai Jiao Tong University Cui DX most influential institution author, The International Journal Nanomedicine prolific journal; Biomaterials cited cocited journal. Nanomaterial-related drug delivery anticancer mechanisms found be widely researched aspects, green synthesis are hotspots. Conclusion summarized characteristics identified countries, institutions, authors, journals, hot topics regarding cancer. Graphical

Language: Английский

Citations

35
Biomedical applications of aptamer-modified chitosan nanomaterials: An updated review DOI Creative Commons
Sonia Fathi‐karkan, Shekoufeh Mirinejad, Fulden Ulucan‐Karnak

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 238, P. 124103 - 124103

Published: March 21, 2023

Among polysaccharides of environmental and economic interest, chitosan (CS) is receiving much attention, particularly in the food biotechnology industries to encapsulate active ingredients immobilize enzymes. CS nanoparticles (CS NPs) combine intrinsic beneficial properties both natural polymers nanoscale particles such as quantum size effect, biocompatibility, biodegradability, ease modification, possessing enhanced capacity for bioimaging, drug delivery, biosensing applications. Aptamers are single-stranded oligonucleotides that can fold into predetermined structures bind corresponding biomolecules. They mainly used targeting ligands biosensors, disease diagnostic kits, treatment strategies. deliver contrast agents drugs cancer cells tissues, control microorganism growth, also precisely target pathogens. Aptamer-conjugated NPs significantly improve efficacy conventional therapies, minimize their side effects on normal overcome permeability retention (EPR) effect. Further, aptamer-conjugated carbohydrate-based nanobiopolymers have shown excellent antibacterial antiviral be develop novel biosensors efficient detection antibiotics, toxins, other This updated review aims provide a comprehensive overview bioapplications innovative therapeutic platforms, limitations, potential future directions.

Language: Английский

Citations

32
Implications of nanotherapeutic advancements to leverage multi-drug resistant breast cancer: The state-of-the-art review DOI Creative Commons

Adhithya Aravindan,

Ashutosh Gupta, Sudheer Moorkoth

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106007 - 106007

Published: Aug. 5, 2024

Globally, cancer is regarded as a severe health issue. Among these breast (BC), the second most common kind in women after skin cancer. According to statistical data from NIH Cancer Institute, expected number of cases was around 3 lakh people, with 7.1 % fatality rate. The rise multidrug resistance (MDR) British Columbia issue it lowers effectiveness existing treatments. Traditional MDR treatment approaches BC have drawbacks, including toxicity, high cost, early discharge, restricted drug load before target, and poor effectiveness. Preventing has depended heavily on developing innovative therapy delivery methods utilizing nanomedicine new diagnosing treating BC. This review discusses its pathophysiology relation tumor kinetics. It focuses latest therapeutic over traditional like Surgery, Chemotherapy, Nanomedicine, Phototherapy, Immunotherapy, Gene therapy. also describes diagnostic techniques using MRI/PET, Mammography, Microwave Sensing, In-silico methods, Molecular techniques, AI-machine learning-based tools. discussed limitations nanoparticles article aims identify efficient ways diagnose treat prevent recurrence.

Language: Английский

Citations

9
Structure and drug delivery relationship of acidic polysaccharides: A review DOI

Riya Banerjee,

K. Jayaram Kumar, John F. Kennedy

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 243, P. 125092 - 125092

Published: May 27, 2023

Language: Английский

Citations

22
Green synthesis of CeVO4 nanoparticles using Azadirechta indica leaves extract and their promising applications as an antioxidant and anticancer agent DOI
Suresh Ghotekar, Parita Basnet, Kun‐Yi Andrew Lin

et al.

Journal of Sol-Gel Science and Technology, Journal Year: 2023, Volume and Issue: 106(3), P. 726 - 736

Published: April 14, 2023

Language: Английский

Citations

20
Synthesis of magnetic chitosan/hyaluronic acid/κ-carrageenan nanocarriers for drug delivery DOI

Maghsoud Amirfarhangi Anbardan,

Siamak Alipour,

Gholam Reza Mahdavinia

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126805 - 126805

Published: Sept. 7, 2023

Language: Английский

Citations

17
Recent Progress in Photocatalytic Removal of Environmental Pollution Hazards in Water Using Nanostructured Materials DOI Creative Commons
Nadiyah Alahmadi

Separations, Journal Year: 2022, Volume and Issue: 9(10), P. 264 - 264

Published: Sept. 22, 2022

Water pollution has become a critical issue because of the Industrial Revolution, growing populations, extended droughts, and climate change. Therefore, advanced technologies for wastewater remediation are urgently needed. contaminants generally classified as microorganisms inorganic/organic pollutants. Inorganic pollutants toxic some them carcinogenic materials, such cadmium, arsenic, chromium, lead, mercury. Organic contained in various including organic dyes, pesticides, personal care products, detergents, industrial wastes. Nanostructured materials could be potential candidates photocatalytic reduction photodegradation since they have unique physical, chemical, optical properties. Enhanced performance nanostructured semiconductors can achieved using numerous techniques; doped with different species, transition metals, noble metals or nonmetals, luminescence agent. Furthermore, another technique to enhance is doping that narrow band gap. Nanostructure modification, surface engineering, heterojunction/homojunction production all take significant time effort. In this review, I report on synthesis characterization we discuss these reducing environmental

Language: Английский

Citations

28