Histopathologic degenerative score as a predictor of minimal clinically important difference in pain and functionality following surgical treatment for disc herniation DOI Creative Commons
Hakija Bečulić, Emir Begagić,

Sabina Šegalo

et al.

Biomolecules and Biomedicine, Journal Year: 2024, Volume and Issue: unknown

Published: July 20, 2024

Lumbar disc herniation (LDH) often results in significant pain and disability, histopathologic (HP) evaluation of intervertebral discs (IVDs) offers critical insights into treatment outcomes. This prospective observational study explores HP changes IVDs their association with clinical outcomes following surgical for LDH. A cohort 141 patients undergoing MRI-confirmed LDH surgery underwent using a semi-quantitative degeneration score (HDS). Preoperatively at six-month follow-up, the comprehensive assessment included Oswestry disability index (ODI) visual analog scale (VAS), minimal clinically important difference (MCID) calculated from ODI VAS. Results indicated associations between higher HDS adverse outcomes, including persistent greater post-surgery. Specifically, an ≥ 7 was predictive (OR = 6.25, 95% CI: 2.56–15.23) measured MCID-ODI (AUC: 0.692, 0.609–0.767, P < 0.001), 8 1.72, 1.04–2.77) MCID-VAS (AUC 0.628, 0.598–0.737, 0.008), highlighting diagnostic potential assessing postoperative recovery. underscores to provide valuable disease progression patients, complementing conventional radiologic methods. The findings support application personalized strategies based on while acknowledging challenges interpretation implementation.

Language: Английский

Histopathologic degenerative score as a predictor of minimal clinically important difference in pain and functionality following surgical treatment for disc herniation DOI Creative Commons
Hakija Bečulić, Emir Begagić,

Sabina Šegalo

et al.

Biomolecules and Biomedicine, Journal Year: 2024, Volume and Issue: unknown

Published: July 20, 2024

Lumbar disc herniation (LDH) often results in significant pain and disability, histopathologic (HP) evaluation of intervertebral discs (IVDs) offers critical insights into treatment outcomes. This prospective observational study explores HP changes IVDs their association with clinical outcomes following surgical for LDH. A cohort 141 patients undergoing MRI-confirmed LDH surgery underwent using a semi-quantitative degeneration score (HDS). Preoperatively at six-month follow-up, the comprehensive assessment included Oswestry disability index (ODI) visual analog scale (VAS), minimal clinically important difference (MCID) calculated from ODI VAS. Results indicated associations between higher HDS adverse outcomes, including persistent greater post-surgery. Specifically, an ≥ 7 was predictive (OR = 6.25, 95% CI: 2.56–15.23) measured MCID-ODI (AUC: 0.692, 0.609–0.767, P < 0.001), 8 1.72, 1.04–2.77) MCID-VAS (AUC 0.628, 0.598–0.737, 0.008), highlighting diagnostic potential assessing postoperative recovery. underscores to provide valuable disease progression patients, complementing conventional radiologic methods. The findings support application personalized strategies based on while acknowledging challenges interpretation implementation.

Language: Английский

Citations

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