Plasmid vector(s) in Bacillus thuringiensis harbor genes for insect pest control and for neglected infectious diseases in humans DOI Creative Commons

Gloria G. Guerrero,

Juan Manuel Favela-Hernández, Isaı́as Balderas-Renterı́a

et al.

Frontiers in Tropical Diseases, Journal Year: 2024, Volume and Issue: 5

Published: Sept. 9, 2024

Plasmids (circular DNA molecules) represent an ingenious strategy for horizontal gene transfer in prokaryotes and eukaryotic cells. harbored bacteria are responsible the spread of traits such as antibiotic resistance, virulence factors, machinery e.g., type IV secretion systems. Remarkably, Bacillus thuringiensis (Bt) cryptic plasmids encode carry genes that, under host environment, replicate concomitate with sporulation, producing parasporal crystalline proteins two major types, (Cry) cytolytic (Cyt), former toxic against different orders insects Lepidopterans, Coleopterans, Dipterans (Cry proteins, MW 50–130 KDa); Cyt produced by B. subspecies israelensis ( Bti )(MW 27-kDa) Dipterans, i.e., mosquitoes black flies. The X-Ray tridimensional structure both types toxins, formed three domains, mostly beta sheets antiparallel (Domain II Domain III) linked through loops lengths. I is a bundle alpha helices. This characterized five conserved blocks, implying conservation mode action. possess helices some similar to antimicrobial peptides. Indeed, action proposed mediated toxin-lipid interaction that hypothetically could result transmembrane ionic channel formation. Several pieces evidence support toxins mammals. question what extent these Bt / plasmid-encoded Cry or can be applied bioinsecticides individually combination Lysinibacillus sphaericus . feasibility being considered promising safe biological crop pests vector-borne neglected infectious diseases issue pinpointed present review.

Language: Английский

Biotechnological and Therapeutic Applications of Bacterial Toxins DOI
Rasika Jinadasa

Published: Jan. 1, 2025

Language: Английский

Citations

0
Sulfonyl-acetohydrazide derivatives as juvenile hormone mimics to be insect growth regulators DOI
Neetika Kumari, Manisha Chaudhary, Pamita Awasthi

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107781 - 107781

Published: Sept. 5, 2024

Language: Английский

Citations

1
Plasmid vector(s) in Bacillus thuringiensis harbor genes for insect pest control and for neglected infectious diseases in humans DOI Creative Commons

Gloria G. Guerrero,

Juan Manuel Favela-Hernández, Isaı́as Balderas-Renterı́a

et al.

Frontiers in Tropical Diseases, Journal Year: 2024, Volume and Issue: 5

Published: Sept. 9, 2024

Plasmids (circular DNA molecules) represent an ingenious strategy for horizontal gene transfer in prokaryotes and eukaryotic cells. harbored bacteria are responsible the spread of traits such as antibiotic resistance, virulence factors, machinery e.g., type IV secretion systems. Remarkably, Bacillus thuringiensis (Bt) cryptic plasmids encode carry genes that, under host environment, replicate concomitate with sporulation, producing parasporal crystalline proteins two major types, (Cry) cytolytic (Cyt), former toxic against different orders insects Lepidopterans, Coleopterans, Dipterans (Cry proteins, MW 50–130 KDa); Cyt produced by B. subspecies israelensis ( Bti )(MW 27-kDa) Dipterans, i.e., mosquitoes black flies. The X-Ray tridimensional structure both types toxins, formed three domains, mostly beta sheets antiparallel (Domain II Domain III) linked through loops lengths. I is a bundle alpha helices. This characterized five conserved blocks, implying conservation mode action. possess helices some similar to antimicrobial peptides. Indeed, action proposed mediated toxin-lipid interaction that hypothetically could result transmembrane ionic channel formation. Several pieces evidence support toxins mammals. question what extent these Bt / plasmid-encoded Cry or can be applied bioinsecticides individually combination Lysinibacillus sphaericus . feasibility being considered promising safe biological crop pests vector-borne neglected infectious diseases issue pinpointed present review.

Language: Английский

Citations

0