Wild-Grown Romanian Eupatorium cannabinum: Advancing Phyto-Nanocarriers via Maltodextrin Micro-Spray Encapsulation—Metabolite Profiling, Antioxidant, Antimicrobial, and Cytotoxicity Insights

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 482 - 482

Published: Feb. 12, 2025

In Romanian ethnopharmacology, Eupatorium cannabinum species is known for its remarkable biological activity. We present an advanced approach to encapsulation using maltodextrin matrices enhance the stability and efficacy of phytoconstituents nanoparticles. Two distinct carrier systems were developed: (i) a direct micro-spray E. in produce maltodextrin-encapsulated (MEC), (ii) two-step process involving preparation new phytocarrier system based on gold nanoparticles (EC-AuNPs), followed by create AuNPs (MEC-AuNPs system). Comprehensive chemical profiling GC–MS ESI–QTOF–MS revealed 80 bioactive molecules, including terpenoids, alkaloids, flavonoids, phytoecdysteroids. Morpho-structural (XRD, FTIR, Raman spectroscopy, SEM) thermal analyses confirmed successful integration NPs within matrices. EC-AuNPs MEC-AuNPs exhibited superior antioxidant activity, significant antimicrobial against major bacterial pathogens (S. aureus, B. subtilis, cereus, P. aeruginosa, S. typhi, coli), enhanced cytotoxicity MCF-7 HT-29 cancer cell lines. This study highlights potential combining with develop multifunctional therapeutic systems. The findings underscore importance phytoconstituent stabilization nanotechnology addressing global resistance advancing innovative medical applications.

Language: Английский

Isolation, structural characteristics and cytotoxicity of the constitutes from Ceratocarpus arenarius L

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 4

Published: Dec. 26, 2024

Seventeen compounds were isolated from the aerial parts of Ceratocarpus arenarius L., including 1 previously undescribed xanthone and 6 firstly compounds. The structures identified by Mass spectrometry NMR spectroscopy. In addition, in vitro cytotoxicity isolates against human oesophageal squamous carcinoma KYSE-150 KYSE-70 cell investigated MTT to identify Genistein (8) 1,4-dihydroxy-2-naphthoic acid (9) as most effective compounds, which could exhibit anti-proliferation activity with IC50 values 39.11 μg/mL 5.71 KYSE-150, 34.07 4.51 KYSE-70, respectively. Swiss target prediction Molecular docking applied reveal action mechanism provide guidance for potential use C. L. antitumor treatment.

Language: Английский

Efficacy of Eupatorium Adenophorum Extract against Pulse Beetle (Callosobruchus chinensis) at Paklihawa Campus, Rupandehi

Journal of the Institute of Agriculture and Animal Science, Journal Year: 2024, Volume and Issue: 38(1), P. 97 - 109

Published: Dec. 31, 2024

A laboratory experiment was carried out at Paklihawa Campus, Rupandehi starting from 15th December 2020 to February 2021, observe the efficacy of Eupatorium adenophorum extract against Callosobruchus chinensis (pulse beetle). completely randomized design with two factors (altitude and concentration) taken. Phytochemical screening allelopathic test were completed during research. Samples collected three altitudes, viz., Paklihawa, Hemja, Tansen, levels concentration (5%, 10%, 15%). This study explored potential E. leaf as a natural pesticide pulse beetles in stored pigeon peas. confirmed bioactive compounds like alkaloids, flavonoids, terpenoids. Extracts different altitudes concentrations 15%) tested, revealing that higher altitude samples significantly increased beetle mortality, achieving complete mortality by tenth day 15%. The also showed inhibitory effects on pea germination, suggesting properties. Overall, offers an eco-friendly alternative for management, supporting sustainable pest control practices.

Language: Английский