The Emerging Role of Water Loss in Dog Aging DOI Creative Commons
Gabriella Guelfi, Camilla Capaccia,

Vicente Francisco Ratto

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 545 - 545

Published: April 4, 2025

Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores emerging role loss as a central underestimated driver functional decline in aging, with focus on dog, both clinically relevant target species model human aging. Age-related alterations metabolism—driven by changes body composition, aquaporin (AQP) expression, electrolyte imbalances, reduced thirst perception, impaired urine concentration—lead to intracellular extracellular dehydration, exacerbating decline. We examine molecular mechanisms regulation involving AQPs osmolytes, describe how dehydration contributes structural metabolic dysfunction across key biological compartments, kidney, brain, bone, skeletal muscle. Physiological hallmark intensifies inflammaging, accelerating tissue degeneration. In particular, we highlight impairs solvent capacity, solute transport, protein conformation, communication. Despite known macronutrients geriatric nutrition, hydration remains an often-overlooked factor aging management. argue its inclusion fourth pillar nutritional approach veterinary geriatrics, alongside protein, fat, fiber. By investigating aging-associated dogs—species that share environments lifestyle patterns humans—we propose hydration-centered strategies promote healthy comparative medicine.

Language: Английский

The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Regeneration, Tissue Repair, and the Regulation of Hair Follicle Growth DOI
Nazli Karimi Ahmadi,

Adnan Berk Dinçsoy

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nicotinamide Counteracts Ultraviolet-B-Induced Cytotoxic Effects and Aquaporins Overexpression in the A375 Melanoma Cell Line DOI Creative Commons
Lara Camillo, Elia Esposto, Laura Cristina Gironi

et al.

Dermato, Journal Year: 2025, Volume and Issue: 5(1), P. 3 - 3

Published: Feb. 19, 2025

Background/objectives: Ultraviolet-B (UVB) represents a major extrinsic factor in skin cancer development, causing cellular changes that are not yet fully understood. Aquaporins (AQPs) family of transmembrane proteins favor water transport and involved several pathways. Nicotinamide (NAM), vitamin B3 derivate, is safe molecule able to reduce UVB-induced damages. This study aims verify whether AQP expression affected by UVB exposure at different dosages times evaluate NAM’s effects against Methods: A375 cells were exposed 40, 100, 200 mJ/cm2 doses analyzed 0, 1, 18, 24 h post-irradiation. Results: We found the 40 dose, post-irradiation, caused most detrimental an overall overexpression dimerization AQPs. However, presence NAM 25 μM, cell cycle was restored, leading improved viability proliferation, reduced ROS levels, DNA damage. Moreover, we decreased AQPs dimerization. Conclusions: Overall, effectively mitigates damage, including overexpression, may serve as protective agent UVB-related

Language: Английский

Citations

0
The Emerging Role of Water Loss in Dog Aging DOI Creative Commons
Gabriella Guelfi, Camilla Capaccia,

Vicente Francisco Ratto

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 545 - 545

Published: April 4, 2025

Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores emerging role loss as a central underestimated driver functional decline in aging, with focus on dog, both clinically relevant target species model human aging. Age-related alterations metabolism—driven by changes body composition, aquaporin (AQP) expression, electrolyte imbalances, reduced thirst perception, impaired urine concentration—lead to intracellular extracellular dehydration, exacerbating decline. We examine molecular mechanisms regulation involving AQPs osmolytes, describe how dehydration contributes structural metabolic dysfunction across key biological compartments, kidney, brain, bone, skeletal muscle. Physiological hallmark intensifies inflammaging, accelerating tissue degeneration. In particular, we highlight impairs solvent capacity, solute transport, protein conformation, communication. Despite known macronutrients geriatric nutrition, hydration remains an often-overlooked factor aging management. argue its inclusion fourth pillar nutritional approach veterinary geriatrics, alongside protein, fat, fiber. By investigating aging-associated dogs—species that share environments lifestyle patterns humans—we propose hydration-centered strategies promote healthy comparative medicine.

Language: Английский

Citations

0