Young Age and Concomitant Cannabis (THC) and Ethanol (EtOH) Exposure Enhances Rat Brain Damage Through Decreased Cerebral Mitochondrial Respiration DOI Creative Commons
Véronique Quenardelle, Anne‐Laure Charles, Anne Charloux

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 918 - 918

Published: Feb. 17, 2025

The reason why young people taking concomitantly cannabis (THC) and ethanol (EtOH) are more prone to stroke is underresearched. To investigate whether an underlying mechanism of increased brain damage could be impaired mitochondrial function, this experiment determined the acute effects EtOH, both alone associated with THC, on respiration oxidative stress (hydrogen peroxide H2O2) (11 weeks) middle-aged (45 in rats, using a high-resolution oxygraph (Oxygraph-2K, Oroboros instruments). In brains, EtOH decreased by -51.76 ± 2.60% (from 32.76 3.82 17.41 1.42 pmol/s/mL, p < 0.0001). 45-week-old decrease was lesser, but still significant -36.0 2.80% 30.73 7.72 20.59 5.48 Concomitant THC aggravated decreases at 11 weeks (-86.86 1.74%, 0.0001) 45 (-73.95 3.69%, Such additional injury enhanced brains (p 0.01). H2O2 production similar age groups (1.0 0.2 versus 1.1 0.08 pmol O2/s/mL) not modified addition. conclusion, significantly impairs concomitant further aggravates such damage, particularly brains. These data support hypothesis that dysfunction might participate occurrence urge for better prevention against addictions adolescents.

Language: Английский

Young Age and Concomitant Cannabis (THC) and Ethanol (EtOH) Exposure Enhances Rat Brain Damage Through Decreased Cerebral Mitochondrial Respiration DOI Creative Commons
Véronique Quenardelle, Anne‐Laure Charles, Anne Charloux

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 918 - 918

Published: Feb. 17, 2025

The reason why young people taking concomitantly cannabis (THC) and ethanol (EtOH) are more prone to stroke is underresearched. To investigate whether an underlying mechanism of increased brain damage could be impaired mitochondrial function, this experiment determined the acute effects EtOH, both alone associated with THC, on respiration oxidative stress (hydrogen peroxide H2O2) (11 weeks) middle-aged (45 in rats, using a high-resolution oxygraph (Oxygraph-2K, Oroboros instruments). In brains, EtOH decreased by -51.76 ± 2.60% (from 32.76 3.82 17.41 1.42 pmol/s/mL, p < 0.0001). 45-week-old decrease was lesser, but still significant -36.0 2.80% 30.73 7.72 20.59 5.48 Concomitant THC aggravated decreases at 11 weeks (-86.86 1.74%, 0.0001) 45 (-73.95 3.69%, Such additional injury enhanced brains (p 0.01). H2O2 production similar age groups (1.0 0.2 versus 1.1 0.08 pmol O2/s/mL) not modified addition. conclusion, significantly impairs concomitant further aggravates such damage, particularly brains. These data support hypothesis that dysfunction might participate occurrence urge for better prevention against addictions adolescents.

Language: Английский

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