Biomarkers shared by frailty and sarcopenia in older adults: A systematic review and meta-analysis

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 73, P. 101530 - 101530

Published: Nov. 25, 2021

Language: Английский

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Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 14, 2023

Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.

Language: Английский

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Chrono-Nutrition: Circadian Rhythm and Personalized Nutrition

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2571 - 2571

Published: Jan. 29, 2023

The human circadian system has a period of approximately 24 h and studies on the consequences “chornodisruption” have greatly expanded. Lifestyle environmental factors modern societies (i.e., artificial lighting, jetlag, shift work, around-the-clock access to energy-dense food) can induce disruptions thereby adversely affect individual health. Growing evidence demonstrates complex reciprocal relationship between metabolism system, in which perturbations one other one. From nutritional genomics perspective, genetic variants clock genes both influence metabolic health modify response diet. Moreover, an interplay rhythm, gut microbiome, epigenome been demonstrated, with diet turn able modulate this link suggesting remarkable plasticity underlying mechanisms. In view, study impact timing eating by matching elements from research chrono-biology, that is, chrono-nutrition, could significant implications for personalized nutrition terms reducing prevalence burden chronic diseases. This review provides overview current interactions nutrition, highlighting how microbiome. addition, possible strategies manage circadian-aligned feeding are suggested.

Language: Английский

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Meal timing and its role in obesity and associated diseases

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 22, 2024

Meal timing emerges as a crucial factor influencing metabolic health that can be explained by the tight interaction between endogenous circadian clock and homeostasis. Mistimed food intake, such delayed or nighttime consumption, leads to desynchronization of internal is associated with an increased risk for obesity disturbances type 2 diabetes cardiovascular diseases. Conversely, meal aligned cellular rhythms optimize performance tissues organs. In this review, we provide overview effects discuss underlying mechanisms. Additionally, explore factors timing, including determinants chronotype genetics, well external influences like social factors, cultural aspects, work schedules. This review could contribute defining meal-timing-based recommendations public initiatives developing guidelines effective lifestyle modifications targeting prevention treatment Furthermore, it sheds light on must considered in design future intervention trials.

Language: Английский

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Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 138 - 138

Published: Jan. 11, 2024

A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, in contemporary society, there a prevalent occurrence misalignments system environmental cues, phenomenon frequently associated with adverse health consequences. The onset most current chronic diseases intimately connected alterations lifestyle practices under various facets, including following: reduced physical activity, exposure artificial light, also acknowledged as light pollution, sedentary behavior coupled consuming energy-dense nutriments, irregular eating frameworks, disruptions sleep patterns (inadequate quality duration), engagement shift work, known jetlag. rapid evolution life domestic routines has significantly outpaced rate genetic adaptation. Consequently, underlying rhythms exposed multiple shifts, thereby elevating susceptibility disease predisposition. comprehensive review endeavors synthesize existing empirical evidence that substantiates conceptual integration clock, biochemical molecular homeostasis, oxidative stress, stimuli imparted exercise, sleep, nutrition.

Language: Английский

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Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 529 - 529

Published: Jan. 31, 2025

Fasting-feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal underscores importance maintaining alignment order to avoid creating metabolic environment conducive carcinogenesis following molecular systemic disruption performance immune function. chronicity such condition may support initiation progression cancer through variety mechanisms, including increased oxidative stress, suppression, activation proliferative signaling pathways. This review aims summarize current evidence from human studies provide an overview potential mechanisms underscoring role chrononutrition (including time-restricted eating) on risk. Current shows that morning chronotype, suggesting physiological rhythms eating timing, associated with lower risk cancer. Also, early prolonged nighttime fasting were also suggests chronotype influences cell cycle regulation, modulation pathways inflammation, gut microbiota fluctuations. In conclusion, although there are no clear guidelines this matter, emerging supports hypothesis time-related (i.e., time/calorie-restricted feeding intermittent/periodic fasting) could potentially lead reduced

Language: Английский

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Sleep and the Mediterranean diet: A systematic review and meta-analysis

Sleep Medicine Reviews, Journal Year: 2025, Volume and Issue: 80, P. 102071 - 102071

Published: Feb. 7, 2025

Language: Английский

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Circadian rhythms, gut microbiota, and diet: Possible implications for health

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2023, Volume and Issue: 33(8), P. 1490 - 1500

Published: May 15, 2023

Over the past years, interest in chrono-nutrition has grown enormously as fundamental role of circadian rhythms regulating most physiological and metabolic processes become clearer. Recently, influence on gut microbiota (GM) composition also emerged, more than half total microbial fluctuates rhythmically throughout day. At same time, other studies have observed that GM itself synchronises host's biological clock through signals a different nature. Therefore, it been hypothesised there is two-way communication between host GM, but researchers only just begun to identify some its action mechanisms. The manuscript aim is, therefore, gather combine latest evidence field with recent research order investigate their relationship potential impact human health.Considering current evidence, desynchronization closely associated an alteration abundance functionality consequent deleterious effects health, such increased risk numerous pathologies, including cardiovascular disease, cancer, irritable bowel depression. A key maintaining balance seems be attributed meal-timing diet quality, well certain metabolites, particular short-chain fatty acids.Future are needed decipher link specific patterns relation disease frameworks.

Language: Английский

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Physiological Rhythms and Biological Variation of Biomolecules: The Road to Personalized Laboratory Medicine

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6275 - 6275

Published: March 27, 2023

The concentration of biomolecules in living systems shows numerous systematic and random variations. Systematic variations can be classified based on the frequency as ultradian (<24 h), circadian (approximately 24 infradian (>24 which are partly predictable. Random biological known between-subject that among set points an analyte from different individuals within-subject variation, is variation around individuals' points. cannot predicted but estimated using appropriate measurement statistical procedures. Physiological rhythms analytes could considered essential elements predictive, preventive, particularly personalized laboratory medicine. This review aims to summarize research have been done about types physiological rhythms, variations, their effects tests. We searched PubMed Web Science databases for rhythm articles English without time restrictions with terms "Biological Within-subject Between-subject Ultradian Circadian rhythm, Infradian rhythms". It was concluded that, effective management predicting, preventing, personalizing medicine, safe valid interpretation patients' test results, both measurands should simultaneously.

Language: Английский

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Individual associations of self-reported sleep duration, sleep quality, chronotype and social jet lag with infectious disease risk

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)

Published: Jan. 23, 2025

Sleep deficiency is associated with infectious disease risk. However, little known about the individual roles of different aspects sleep, including sleep duration, quality, timing (assessed by chronotype) and regularity (in form social jet lag) in this context. Here, we examined associations probability reporting a cold or other infections self-reported quality chronotype sample 642 adults, lag subsample 274 adults. We found that short (≤ 6 h) long sleepers (≥ 9 were more likely to report past 30 days than average (7–8 h). Also, individuals definite evening those an intermediate chronotype, even when controlling for duration. Finally, was dose-dependently risk 12 months, independently chronotype. No colds. The findings show are incidence reported This article part Theo Murphy meeting issue ‘Circadian rhythms infection immunity’.

Language: Английский

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