npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)
Published: March 30, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12
Published: Nov. 23, 2021
Parkinson’s disease (PD) is a complex neurodegenerative disorder featuring both motor and nonmotor symptoms associated with progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Oxidative stress (OS) has been implicated pathogenesis PD. Genetic environmental factors can produce OS, which as core contributor to initiation progression PD through degeneration neurons. The transcription factor nuclear erythroid 2-related 2 (Nrf2) orchestrates activation multiple protective genes, including heme oxygenase-1 (HO-1), protects cells from OS. Nrf2 also shown exert anti-inflammatory effects modulate mitochondrial function biogenesis. Recently, series studies have reported that different bioactive compounds were be able activate Nrf2/antioxidant response element (ARE) ameliorate PD-associated neurotoxin, animal models tissue culture. In this review, we briefly overview sources OS association between Then, provided concise Nrf2/ARE pathway delineated role played by Nrf2/HO-1 At last, expand our discussion neuroprotective pharmacological modulation potential application activators for treatment This review suggests signaling therapeutic target
Language: Английский
Citations
75
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(10), P. 5709 - 5709
Published: May 20, 2022
The term ferroptosis refers to a peculiar type of programmed cell death (PCD) mainly characterized by extensive iron-dependent lipid peroxidation. Recently, has been suggested as potential new strategy for the treatment several cancers, including breast cancer (BC). In particular, among BC subtypes, triple negative (TNBC) is considered most aggressive, and conventional drugs fail provide long-term efficacy. this context, our study's purpose was investigate mechanism in lines reveal significance heme oxygenase (HO) modulation process, providing biochemical approaches. HO's effect on evaluated MTT tests, gene silencing, Western blot analysis, measurement reactive oxygen species (ROS), glutathione (GSH) hydroperoxide (LOOH) levels. order assess implication, different approaches were exploited, using two distinct HO-1 inducers (hemin curcumin), well-known HO inhibitor (SnMP) selective HO-2 inhibitor. data obtained showed contribution onset ferroptosis; induction seemed accelerate process. Moreover, results suggest role erastin-induced ferroptosis. view above, can offer novel approach treatment.
Language: Английский
Citations
38
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1405 - 1421
Published: Feb. 14, 2023
Excessive oxidative stress and apoptosis of ovarian granulosa cells lead to abnormal follicular development ovulation disorders in polycystic ovary syndrome (PCOS). Carnosol is a plant-derived polyphenol that has been proven exhibit several cell protective effects. In this study, we established hyperandrogenic PCOS models both vitro vivo. the human line, KGN cells, decreased viability mitochondrial membrane potential, upregulated reactive oxygen species (ROS) level induced by DHT were partly reversed carnosol. Western blotting results showed carnosol treatment inhibited DHT-activated apoptotic pathway activating nuclear factor-erythroid 2-related factor (Nrf2)/heme oxygenase 1 (HO-1). Knockdown Nrf2 transfecting with siRNA or inhibiting HO-1 zinc protoporphyrin (ZnPP) blocked effects Computational modeling pull-down assay confirmed direct binding kelch-like ECH-associated protein (Keap1). vivo intraperitoneal administration (50 100 mg/kg) improved estrous cycle disorders, ovary, elevated androgen mice. summary, an effective role DHT-treated protecting against mouse phenotypes through Keap1-mediated activation Nrf2/HO-1 signaling.
Language: Английский
Citations
26
Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 258 - 258
Published: Jan. 15, 2024
Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is congenital blood disorder characterized by considerable phenotypic diversity. It comprises group of disorders, with sickle anemia (SCA) being most prevalent serious genotype. Although there have been some systematic reviews global data, worldwide statistics regarding SCD prevalence, morbidity, mortality remain scarce. In developed countries lower number patients, cutting-edge technologies led to development new treatments. However, developing settings where (SCD) more prevalent, medical management, rather than cure, still relies on use hydroxyurea, transfusions, analgesics. This that affects red cells, consequently affecting organs diverse manners. We discuss its etiology advent technologies, but aim this study understand various types nutrition-related studies involving individuals suffering from SCD, particularly Africa. The interplay environment, food, gut microbiota, along their respective genomes collectively known as microbiome, host metabolism responsible for mediating metabolic phenotypes modulating microbiota. addition, it serves purpose providing essential nutrients. Moreover, engages direct interactions homeostasis immune system, well indirect via metabolites. Nutrition interventions nutritional care are mechanisms addressing increased nutrient expenditures important aspects supportive management patients SCD. Underprivileged areas Sub-Saharan Africa should be accompanied efforts define promote Their importance key maintaining well-being quality life, especially because products limited, while native medicinal plant resources acknowledged.
Language: Английский
Citations
14
Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27527 - e27527
Published: March 1, 2024
Ulcerative colitis is a common type of inflammatory bowel disease that affects millions individuals around the world. Traditional UC treatment has focused on suppressing immune responses rather than treating underlying causes UC, which include oxidative stress, inflammation, and microbiota dysbiosis. Diosmin (DIO), naturally occurring flavonoid, possesses antioxidant anti-inflammatory properties. This study aimed to assess efficacy DIO in dextran-sulfate sodium (DSS)-induced colitis, investigate some its mechanisms, with an emphasis Akkermansia muciniphila abundance, markers, intestinal barrier function. C57BL/6 mice were given 4% (w/v) DSS induce colitis. DSS-induced administered (100 200 mg/kg) or sulfasalazine orally for 7 days. Every day, activity index (DAI) was determined by recording body weight, diarrhea, bloody stool. Changes fecal A. colonic MUC1 MUC2 expression, as well stress markers all assessed. Histopathological changes, PIK3PR3 ZO-1 levels, immunohistochemical examinations occludin claudin-1, investigated. administration resulted dose-dependent decrease DAI, increase abundance expression while decreasing expression. also dramatically reduced inflammation regulating NF-κB Nrf2 cascades, restored integrity inhibiting PIK3R3 inducing ZO-1, improved occludin/claudin-1 gene immunostaining. provides first evidence preserves increases However, more research required explore impact overall composition diversity gut microbiota. Likewise, it will be important fully understand molecular mechanisms maintains function potential use adjuvant UC.
Language: Английский
Citations
12
Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: March 31, 2024
Language: Английский
Citations
11
Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34121 - e34121
Published: July 1, 2024
Stroke is the second leading cause of death and third disability worldwide. Globally, 68 % all strokes are ischemic, with 32 being hemorrhagic. Ischemic stroke (IS) poses significant challenges globally, necessitating development effective therapeutic strategies.IS among deadliest illnesses. Major functions played by neuroimmunity, inflammation, oxidative stress in multiple intricate pathways IS. Secondary brain damage specifically caused early pro-inflammatory activity that follows cerebral ischemia, which brought on excessive activation local microglia infiltration circulating monocytes macrophages.Resveratrol, a natural polyphenol found grapes berries, has shown promise as neuroprotective agent This review offers comprehensive overview resveratrol's role IS, focusing its mechanisms action potential. Resveratrol exerts effects activating nuclear factor erythroid 2-related 2 (NRF2) sirtuin 1 (SIRT1) pathways. SIRT1 resveratrol triggers deacetylation downstream targets like peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) forkhead box protein O (FOXO), regulating mitochondrial biogenesis, antioxidant defense, cellular response. Consequently, promotes survival inhibits apoptosis IS.Moreover, activates NRF2 pathway, key mediator Activation through enhances expression enzymes, heme oxygenase-1 (HO-1) NAD(P)H quinone oxidoreductase (NQO1), neutralize reactive oxygen species mitigate ischemic brain. Combined, contributes to reducing stress, IS.Preclinical studies demonstrate improves functional outcomes, reduces infarct size, regulates blood flow preserves neuronal integrity. Gaining understanding these holds for targeted interventions aimed at promoting facilitating recovery IS patients aid future this matter.
Language: Английский
Citations
9
Immunological Reviews, Journal Year: 2024, Volume and Issue: 323(1), P. 19 - 39
Published: March 9, 2024
Summary Natural Killer (NK) cells are a top contender in the development of adoptive cell therapies for cancer due to their diverse antitumor functions and ability restrict activation against nonmalignant cells. Despite success hematologic malignancies, NK cell‐based have been limited context solid tumors. Tumor undergo various metabolic adaptations sustain immense energy demands that needed support rapid uncontrolled proliferation. As result, tumor microenvironment (TME) is depleted nutrients fuel immune activity contains several immunosuppressive metabolites hinder functions. Further, we now know status main determining factor effector Hence, withstand adapt these metabolically hostile conditions imperative effective sustained TME. With this mind, review consequences hostility TME on metabolism function. We also discuss tumor‐like programs induced by STAT3‐mediated expansion thrive Finally, examine how other approaches can be applied enhance
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4654 - 4654
Published: April 25, 2024
The supply and control of iron is essential for all cells vital many physiological processes. All functions activities are expressed in conjunction with iron-binding molecules. For example, natural chelators such as transferrin chelator–iron complexes haem play major roles metabolism human physiology. Similarly, the mainstay treatments most common diseases metabolism, namely deficiency anaemia overload, involve iron–chelator iron-chelating drugs deferiprone (L1), deferoxamine (DF) deferasirox. Endogenous citric acid glutathione exogenous ascorbic also important homeostasis. Recent advances treatment effective ferric tri-maltol complex (feraccru or accrufer) transfusional overload using L1 L1/DF combinations have decreased associated mortality morbidity improved quality life millions patients. Many other chelating ciclopirox, dexrazoxane EDTA used daily by patients diseases. their metabolites iron-chelation capacity hydroxyurea, tetracyclines, anthracyclines aspirin, well dietary molecules gallic acid, caffeic quercetin, ellagic maltol phytochelators, known to interact affect related Different interactions observed presence essential, xenobiotic, diagnostic theranostic metal ions competing iron. Clinical trials Parkinson’s, Alzheimer’s neurodegenerative diseases, HIV infections, cancer, diabetic nephropathy inflammation, highlight importance chelation therapy clinical conditions. proposed use modulating ferroptosis signifies a new era design therapeutic strategies introduction artificial intelligence guidance optimal outcomes personalised medicine expected increase further impact medicine, survival metabolic disorders
Language: Английский
Citations
8
Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 1, 2025
Background/Objective Cadmium (Cd) is an extremely toxic heavy metal and environmental toxicant, which leads to renal damage by causing oxidative stress. Rhamnazin (RAM) a novel flavonoid, possesses multiple pharmacological activities. Therefore, the present study was planned determine nephroprotective effects of RAM against Cd-prompted toxicity in rats. Methodology In this investigation, 24 male albino rats were distributed into four equal groups, i.e., control, CdCl 2 -intoxicated group (2 mgkg −1 ), + RAM-treated 20 RAM-only treated (20 ). After oral dose administration for 30 days, alterations Nrf2/Keap1 pathway, Cd concentration, antioxidant profile, stress markers, function inflammatory apoptotic kidney histology analyzed. Result The results current revealed that exposure significantly ( P < .05) increased Keap1 expression, while decreasing expressions Nrf2 genes level total status (TAS). Additionally, it decreased activities enzymes. Whereas, levels malondialdehyde (MDA), reactive oxygen species (ROS), oxidant (TOS) increased. concentration tissues. such as urea, urobilinogen, urinary proteins, creatinine, injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL). On contrary, reduced albumin creatinine clearance. Furthermore, markers kidneys. Besides, Bax, caspase-3, caspase-9, whereas lessened Bcl-2 level. Moreover, adverse histoarchitectural changes observed following exposure. However, treatment with restored all kidneys Conclusion Our findings highlight potential valuable therapeutic candidate metal-induced damage.
Language: Английский
Citations
1