Prognostic feature based on androgen-responsive genes in bladder cancer and screening for potential targeted drugs DOI Creative Commons
Jiang Zhao, Qian Zhang,

Cunle Zhu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 31, 2024

Abstract Objectives Bladder cancer (BLCA) is a tumor that affects men more than women. The biological function and prognostic value of androgen-responsive genes (ARGs) in BLCA are currently unknown. To address this, we established an androgen signature to determine the prognosis BLCA. Methods Sequencing data for from TCGA GEO datasets were used research. microenvironment (TME) was measured using Cibersort ssGSEA. Prognosis-related identified risk score model constructed univariate Cox regression, LASSO multivariate regression. Drug sensitivity analysis performed Genomics drug (GDSC). Real-time quantitative PCR assess expression representative clinical samples. Results ARGs (especially CDK6, FADS1, PGM3, SCD, PTK2B, TPD52) might regulate progression different patterns lead immune cell infiltration. indicates patients with higher scores have poorer prognosis, stromal infiltration, enrichment functions. Single-cell RNA analysis, bulk data, proved reliability this model, nomogram also use. prediction showed high-risk had better response fludarabine, AZD8186, carmustine. Conclusion played important role progression, has high accuracy predicting provides effective medication guidelines.

Language: Английский

Regulation of the tumor immune microenvironment by cancer-derived circular RNAs DOI Creative Commons
Liping Guan, Qian Hao,

Fenfen Shi

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(2)

Published: Feb. 16, 2023

Circular RNA (circRNAs) is a covalently closed circular non-coding formed by reverse back-splicing from precursor messenger RNA. It found widely in eukaryotic cells and can be released to the surrounding environment captured other cell types. This, circRNAs serve as connections between different types for mediation of multiple signaling pathways. CircRNAs reshape tumor microenvironment (TME), key factor involved all stages cancer development, regulating epithelial-stromal transformation, vascularization, immune function, inflammatory responses. Immune are most abundant cellular TME components, they have profound toxicity cells. This review summarizes circRNA regulation cells, including T natural killer macrophages; highlights impact on progression, treatment, prognosis; indicates new targets immunotherapy.

Language: Английский

Citations

28
Tracing the Evolution of Sex Hormones and Receptor‐Mediated Immune Microenvironmental Differences in Prostate and Bladder Cancers: From Embryonic Development to Disease DOI Creative Commons
Dengxiong Li, Zhipeng Wang, Qingxin Yu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract The bladder and prostate originate from the urogenital sinus. However, cancer (BC) is usually classified as an immune “hot” tumor, whereas (PCa) deemed “cold” tumor according to microenvironment (TME) clinical outcomes. To investigate differences between BC PCa, studies are compared focusing on regulation mediated by sex hormones receptors identify key genes pathways responsible for differences. From a developmental perspective, it shown that PCa activate similar those in stage. During development, differential expression function of androgen receptor (AR) across cell types may contribute its dual role promoting inhibiting immunity different cells. Androgen deprivation therapy affects AR cells within TME, influencing infiltration antitumor function. Additionally, estrogenα estrogenβ exert contrasting effects BC, which hold potential modifying phenotypes. Future research should target involved development clarify regulatory similarities PCa.

Language: Английский

Citations

1
Cheminformatic Analysis and Machine Learning Modeling to Investigate Androgen Receptor Antagonists to Combat Prostate Cancer DOI Creative Commons
Tianshi Yu, Chanin Nantasenamat, Supicha Kachenton

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(7), P. 6729 - 6742

Published: Feb. 13, 2023

Prostate cancer (PCa) is a major leading cause of mortality among males. There have been numerous studies to develop antagonists against androgen receptor (AR), crucial therapeutic target for PCa. This study systematic cheminformatic analysis and machine learning modeling the chemical space, scaffolds, structure-activity relationship, landscape human AR antagonists. are 1678 molecules as final data sets. Chemical space visualization by physicochemical property has demonstrated that from potent/active class generally mildly smaller molecular weight (MW), octanol-water partition coefficient (log P), number hydrogen-bond acceptors (nHA), rotatable bonds (nRot), topological polar surface area (TPSA) than intermediate/inactive class. The in principal component (PCA) plot shows significant overlapping distributions between molecules; intensively distributed, while widely sparsely distributed. Murcko scaffold shown low diversity general, even lower molecules, indicating necessity developing with novel scaffolds. Furthermore, identified 16 representative Among them, scaffolds 1, 2, 3, 4, 7, 8, 10, 11, 15, highly favorable due their high enrichment factor values. Based on analysis, local relationships (SARs) were investigated summarized. In addition, global SAR was explored quantitative relationship (QSAR) modelings visualization. A QSAR classification model incorporating all stands out best total 12 candidate models (built PubChem fingerprint, extra trees algorithm, accuracy training set: 0.935, 10-fold cross-validation 0.735 test 0.756). Deeper insights into highlighted seven activity cliff (AC) generators (ChEMBL molecule IDs: 160257, 418198, 4082265, 348918, 390728, 4080698, 6530), which provide valuable information medicinal chemistry. findings this new guidelines hit identification lead optimization development

Language: Английский

Citations

14
DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer DOI
Yan Li, Yongying Zhou,

Mingliu Huang

et al.

Cellular Signalling, Journal Year: 2022, Volume and Issue: 102, P. 110553 - 110553

Published: Dec. 5, 2022

Language: Английский

Citations

17
Sex-specific associations of sex hormone binding globulin and risk of bladder cancer DOI Creative Commons

Junyong Ou,

Hai Bi,

Haobin Zhou

et al.

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Males have a three times higher risk of diagnosis bladder cancer (Bca) than females. Sex hormone-binding globulin (SHBG) may be associated with Bca risk. However, the sex-specific role SHBG in remains unclear. In this study, we aimed to determine Bca. A univariable Mendelian randomization (MR) analysis involving 369,426 men and 395,375 women was conducted assess causal relationship between testosterone Sensitivity analyses multivariable MR were confirm robustness our results. Linkage disequilibrium score regression assessed genetic correlation these diseases influenced by heredity. Univariable results showed that one-SD elevated related low males (OR: 0.60, 95% CI: 0.39-0.93; p = 0.022) but had no benefit Genetically predicted BT positively 1.59; 1.06-2.40; 0.027). MR, levels not male after controlling for BT. Our findings do provide evidence support although an association observed analysis. Further research is needed identify underlying pathways.

Language: Английский

Citations

0
Bladder cancer biomarkers DOI Creative Commons

Dominik Godlewski,

Dorota Bartusik‐Aebisher,

Sara Czech

et al.

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6

Published: March 25, 2025

Bladder cancer (BCa) is among the most frequently diagnosed urinary tract cancers, characterized by a high recurrence rate and significant clinical heterogeneity. Effective diagnosis treatment of BCa demand continuous advancements in medical technologies, particularly given limitations classical methods such as cystoscopy urine cytology. A comprehensive search PubMed Web Science was conducted using relevant keywords to structure this narrative review. Additionally, specialist journals were reviewed. Only articles English included, with selection based on titles, abstracts, availability full texts. In recent years, biomarkers have emerged crucial tools complementing traditional techniques, providing more precise, sensitive, non-invasive for early detection, prognosis, monitoring response BCa. Molecular, genetic, protein enable deeper understanding biology, creating opportunities personalized therapy tailored individual patient needs. However, despite their potential, certain challenges remain, including standardization, validation, integration into routine practice. This review highlights transformative potential oncological care. It underscores importance incorporating these innovations refine diagnostic therapeutic approaches, ultimately improving outcomes. Modern prognostic can enhance outcomes enabling disease detection reducing risks. progress promises improve patients’ quality life minimizing burden fostering effective, care strategies.

Language: Английский

Citations

0
Expression, distribution, and function of sex hormone receptors in the rabbit brain DOI Creative Commons

Beatriz Molina,

Gabriela González‐Mariscal,

Ignacio Camacho‐Arroyo

et al.

Hormones and Behavior, Journal Year: 2025, Volume and Issue: 173, P. 105762 - 105762

Published: May 21, 2025

Language: Английский

Citations

0
A comprehensive review on methotrexate containing nanoparticles; an appropriate tool for cancer treatment DOI
Hanifeh Shariatifar,

Fateme Ranjbarian,

Fahimeh Hajiahmadi

et al.

Molecular Biology Reports, Journal Year: 2022, Volume and Issue: 49(11), P. 11049 - 11060

Published: Sept. 12, 2022

Language: Английский

Citations

15
Sex differences in cancer and immunotherapy outcomes: the role of androgen receptor DOI Creative Commons
Junzhe Zhao, Qian Wang,

A. Tan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 28, 2024

Across the wide range of clinical conditions, there exists a sex imbalance where biological females are more prone to autoimmune diseases and males some cancers. These discrepancies combinatory consequence lifestyle environmental factors such as smoking, alcohol consumption, obesity, oncogenic viruses, well other intrinsic traits including chromosomes hormones. While emergence immuno-oncology (I/O) has revolutionised cancer care, efficacy across multiple cancers may be limited because complex, dynamic interplay between tumour its microenvironment (TME). Indeed, gender can also influence varying effectiveness I/O. Androgen receptor (AR) plays an important role in tumorigenesis shaping TME. Here, we lay out epidemiological context disparity then review current literature on how AR signalling contributes observation via altered development immunology. We offer insights into AR-mediated immunosuppressive mechanisms, with hope translating preclinical evidence oncology improved outcomes personalised, I/O-based care.

Language: Английский

Citations

3
Research progress on circular RNA in the regulation of drug resistance in genitourinary cancers DOI Creative Commons
Pengcheng Hu,

Junxia Yao,

Kejie Wang

et al.

Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)

Published: April 15, 2025

In recent years, significant progress has been made in the management of genitourinary cancers, primarily due to advancements surgical techniques, emergence targeted therapy and immunotherapy, refinement chemotherapy agents. However, despite expanding arsenal treatment modalities, some patients still face challenges associated with drug resistance, which hinders efforts improve survival rates. Circular RNAs (circRNAs) are covalently closed RNA molecules a stable structure unique ability form reverse splicing loops. Increasing evidence suggests that abnormal expression circRNAs is significantly correlated occurrence genitourinay indicating their potentials as diagnostic prognostic biomarkers, well new targets for treatment. Although research on cancers progressed, it preliminary stage. This review summarizes properties functions circRNAs, focusing molecular cellular mechanisms involved mediating cancer-related resistance system, including autophagy, epithelial-mesenchymal transition, glycolysis, etc. The clinical potential regulating also carefully discussed.

Language: Английский

Citations

0