Hydrogen Sulfide Biology and Its Role in Cancer

Molecules, Journal Year: 2022, Volume and Issue: 27(11), P. 3389 - 3389

Published: May 25, 2022

Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role many pathophysiological processes the body. can be endogenously through enzymes analogous to cysteine family, while exogenous source may involve inorganic salts. H2S has recently been well investigated with regard onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. considered oncogenic gas, potential therapeutic target for treating diagnosing cancers, due its mediating development tumorigenesis. Here this review, in-detail up-to-date explanation different malignancies reported. The study summarizes synthesis H2S, roles, signaling routes, expressions, release malignancies. Considering importance biological molecule, we believe review esteemed journal will highlight scientific community.

Language: Английский

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Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102066 - 102066

Published: Sept. 7, 2023

Language: Английский

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The potential role of hydrogen sulfide in cancer cell apoptosis

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: March 6, 2024

Abstract For a long time, hydrogen sulfide (H 2 S) has been considered toxic compound, but recent studies have found that H S is the third gaseous signaling molecule which plays vital role in physiological and pathological conditions. Currently, large number of shown mediates apoptosis through multiple pathways to participate cancer occurrence development, for example, PI3K/Akt/mTOR MAPK pathways. Therefore, regulation production metabolism mediate apoptotic process cells may improve effectiveness treatment. In this review, mechanism cell mammals are summarized.

Language: Английский

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Emerging roles of cystathionine β-synthase in various forms of cancer

Redox Biology, Journal Year: 2022, Volume and Issue: 53, P. 102331 - 102331

Published: May 10, 2022

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is markedly increased in many forms cancer, including colorectal, ovarian, lung, breast and kidney, while other cancers (liver cancer glioma) it becomes downregulated. According to clinical database data high-CBS-expressor (e.g. colon or ovarian cancer), high CBS typically predicts lower survival, low-CBS-expressor liver low associated with survival. In high-CBS expressing tumor cells, CBS, its product hydrogen sulfide (H2S) serves as a bioenergetic, proliferative, cytoprotective stemness factor; also supports angiogenesis epithelial-to-mesenchymal transition microenvironment. current article reviews various tumor-cell-supporting roles CBS/H2S axis expressor overviews anticancer effects silencing pharmacological inhibition models vitro vivo; outlines potential approaches for biomarker identification, support future targeted therapies based on inhibition.

Language: Английский

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Thiol-based Oxidative Posttranslational Modifications (OxiPTMs) of Plant Proteins

Plant and Cell Physiology, Journal Year: 2022, Volume and Issue: 63(7), P. 889 - 900

Published: March 21, 2022

Abstract The thiol group of cysteine (Cys) residues, often present in the active center protein, is particular importance to protein function, which significantly determined by redox state a protein’s environment. Our knowledge different thiol-based oxidative posttranslational modifications (oxiPTMs), compete for specific groups, has increased over last 10 years. principal oxiPTMs include S-sulfenylation, S-glutathionylation, S-nitrosation, persulfidation, S-cyanylation and S-acylation. role each oxiPTM depends on cellular state, turn homeostasis under either optimal or stressful conditions. Under such conditions, metabolism molecules as glutathione, NADPH (reduced nicotinamide adenine dinucleotide phosphate), nitric oxide, hydrogen sulfide peroxide can be altered, exacerbated and, consequently, outside cell’s control. This review provides broad overview these physiological unfavorable regulate function target proteins.

Language: Английский

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Interactions of reactive sulfur species with metalloproteins

Redox Biology, Journal Year: 2023, Volume and Issue: 60, P. 102617 - 102617

Published: Jan. 27, 2023

Reactive sulfur species (RSS) entail a diverse family of derivatives that have emerged as important effector molecules in H2S-mediated biological events. RSS (including H2S) can exert their roles via widespread interactions with metalloproteins. Metalloproteins are essential components along the metabolic route oxygen body, from transport and storage O2, through cellular respiration, to maintenance redox homeostasis by elimination reactive (ROS). Moreover, heme peroxidases contribute immune defense killing pathogens using oxygen-derived H2O2 precursor for stronger oxidants. Coordination reactions metal centers primary means alter fundamental functions. In addition RSS-mediated metalloprotein functions, reduction high-valent results radical formation opens way subsequent per- polysulfide formation, which may implications protection against oxidative stress signaling. Furthermore, recent findings pointed out potential role substrates mitochondrial energy production cytoprotective capacity, involvement The current review summarizes protein special emphasis on mechanistic aspects, sulfide-mediated signaling, pathophysiological consequences. A deeper understanding actions molecular level is primordial H2S-related drug development advancement medicine.

Language: Английский

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Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 209, P. 115444 - 115444

Published: Feb. 1, 2023

Language: Английский

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A ratiometric near-infrared fluorescent probe with a large Stokes shift for rapid and sensitive detection of hydrogen sulfide in food samples and imaging in biological system

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 127, P. 106005 - 106005

Published: Jan. 23, 2024

Language: Английский

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Application of nanotechnology in the treatment of glomerulonephritis: current status and future perspectives

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 3, 2024

Abstract Glomerulonephritis (GN) is the most common cause of end-stage renal failure worldwide; in cases, it cannot be cured and can only delay progression disease. At present, main treatment methods include symptomatic therapy, immunosuppressive replacement therapy. However, effective GN hindered by issues such as steroid resistance, serious side effects, low bioavailability, lack precise targeting. With widespread application nanoparticles medical treatment, novel have emerged for kidney diseases. Targeted transportation drugs, nucleic acids, other substances to tissues even cells through nanodrug delivery systems reduce systemic effects adverse reactions drugs improve effectiveness. The high specificity enables them bind ion channels block or enhance channel gating, thus improving inflammation. This review briefly introduces characteristics GN, describes status systematically summarizes research achievements primary diabetic nephropathy lupus nephritis, analyzes recent therapeutic developments, outlines promising directions, gas signaling molecule ultrasmall nanoparticles. current summarized provide a reference better future. Graphical

Language: Английский

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Sulfur-based fluorescent probes for biological analysis: A review

Talanta, Journal Year: 2024, Volume and Issue: 279, P. 126515 - 126515

Published: July 9, 2024

Language: Английский

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