Molecular Therapy — Nucleic Acids,
Journal Year:
2024,
Volume and Issue:
35(1), P. 102136 - 102136
Published: Feb. 2, 2024
Autism
is
a
widespread
neurodevelopmental
disorder.
Although
the
research
on
autism
spectrum
disorders
has
been
increasing
in
past
decade,
there
still
no
specific
answer
to
its
mechanism
of
action
and
treatment.
As
pro-inflammatory
microRNA,
miR-301a
abnormally
expressed
various
psychiatric
diseases
including
autism.
Here,
we
show
that
deletion
inhibition
exhibited
two
distinct
abnormal
behavioral
phenotypes
mice.
We
observed
mice
impaired
learning/memory,
enhanced
anxiety.
On
contrary,
effectively
reduced
maternal
immune
activation
(MIA)-induced
autism-like
behaviors
further
demonstrated
bound
3′UTR
region
SOCS3,
led
upregulation
SOCS3
hippocampus.
The
last
result
reduction
inflammatory
response
by
inhibiting
phosphorylation
AKT
STAT3,
expression
level
IL-17A
poly(I:C)-induced
features
obtained
data
revealed
as
critical
participant
partial
behavior
phenotypes,
which
may
exhibit
divergent
role
between
gene
knockout
knockdown.
Our
findings
ascertain
negatively
regulates
MIA-induced
could
present
new
therapeutic
target
for
ameliorating
abnormalities
Genes,
Journal Year:
2022,
Volume and Issue:
13(12), P. 2344 - 2344
Published: Dec. 12, 2022
In
the
studies
of
Alzheimer's
disease
(AD),
jointly
analyzing
imaging
data
and
genetic
provides
an
effective
method
to
explore
potential
biomarkers
AD.
AD
can
be
separated
into
healthy
controls
(HC),
early
mild
cognitive
impairment
(EMCI),
late
(LMCI)
meantime,
identifying
important
progression,
these
in
provide
valuable
insights
understanding
mechanism
this
paper,
we
present
a
novel
fusion
weighted
random
forest
mine
features.
Specifically,
amplify
difference
among
AD,
LMCI,
EMCI
HC
by
introducing
eigenvalues
calculated
from
gene
Applied Neuropsychology Adult,
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 10
Published: July 6, 2023
Dementia
is
characterized
by
a
progressive
cognitive
decline
that
could
be
caused
several
disorders.
Autism
spectrum
disorder
(ASD)
and
attention
deficit
hyperactivity
(ADHD)
are
two
prevalent
neurodevelopmental
disorders
might
overlap
with
dementia
symptoms.
Hence,
this
study
aimed
to
evaluate
the
ASD
ADHD
symptoms
in
patients
referred
memory
clinic
Iran.
We
recruited
65
instructed
them
fill
out
autism
quotient
(AQ)
Conners'
Adult
Rating
Scales
(CAARS)
questionnaires.
Considering
cutoff
points
of
AQ
CAARS
questionnaires,
18.5%
participants
were
at
higher
risk
ASD,
35.4%
ADHD.
The
results
indicated
common
comorbidities
which
can
increase
disease
burden.
Specialized
screening
tools
elderly
population
needed
prevent
misdiagnoses
due
symptom
overlaps.
Discover Mental Health,
Journal Year:
2022,
Volume and Issue:
2(1)
Published: March 24, 2022
Loss-of-function
variants
in
the
dystrophin
gene,
a
well-known
cause
of
muscular
dystrophies,
have
emerged
as
mutational
risk
mechanism
for
autism
spectrum
disorder
(ASD),
which
turn
is
highly
prevalent
(~
1%)
genetically
heterogeneous
neurodevelopmental
disorder.
Although
association
intellectual
disability
with
dystrophinopathies
Duchenne
(DMD)
and
Becker
dystrophy
(BMD)
has
been
long
established,
their
ASD
more
recent,
genotype-ASD
phenotype
correlation
unclear.
We
therefore
present
review
literature
focused
on
prevalence
among
dystrophinopathies,
relevance
isoforms,
most
particularly
genetic
background
to
etiology
these
patients.
Four
families
ASD-DMD/BMD
patients
are
also
reported
here
first
time.
These
include
single
individual,
ASD-discordant
ASD-concordant
monozygotic
twins,
non-identical
triplets.
Notably,
two
unrelated
individuals,
were
ascertained
because
at
ages
15
5
years
respectively,
rare
still
poorly
characterized,
suggesting
that
some
may
compromise
brain
prominently.
Whole
exome
sequencing
individuals
together
suggest,
although
based
preliminary
data,
complex
architecture
underlying
large
medium
effect.
The
need
establishment
consortia
genomic
investigation
patients,
shed
light
ASD,
discussed.
Molecular Therapy — Nucleic Acids,
Journal Year:
2024,
Volume and Issue:
35(1), P. 102136 - 102136
Published: Feb. 2, 2024
Autism
is
a
widespread
neurodevelopmental
disorder.
Although
the
research
on
autism
spectrum
disorders
has
been
increasing
in
past
decade,
there
still
no
specific
answer
to
its
mechanism
of
action
and
treatment.
As
pro-inflammatory
microRNA,
miR-301a
abnormally
expressed
various
psychiatric
diseases
including
autism.
Here,
we
show
that
deletion
inhibition
exhibited
two
distinct
abnormal
behavioral
phenotypes
mice.
We
observed
mice
impaired
learning/memory,
enhanced
anxiety.
On
contrary,
effectively
reduced
maternal
immune
activation
(MIA)-induced
autism-like
behaviors
further
demonstrated
bound
3′UTR
region
SOCS3,
led
upregulation
SOCS3
hippocampus.
The
last
result
reduction
inflammatory
response
by
inhibiting
phosphorylation
AKT
STAT3,
expression
level
IL-17A
poly(I:C)-induced
features
obtained
data
revealed
as
critical
participant
partial
behavior
phenotypes,
which
may
exhibit
divergent
role
between
gene
knockout
knockdown.
Our
findings
ascertain
negatively
regulates
MIA-induced
could
present
new
therapeutic
target
for
ameliorating
abnormalities
