Chemical composition, antioxidant and antimicrobial activities of Vaccinium macrocarpon (Ericaceae) and Camellia sinensis (Theaceae) extracts

Regulatory Mechanisms in Biosystems, Journal Year: 2024, Volume and Issue: 15(3), P. 642 - 647

Published: July 7, 2024

In the modern scientific community, considerable attention is given to studying pharmacological activity of catechin and anthocyanin derivatives. However, a comparative analysis antioxidant antimicrobial activities extracts rich in anthocyanins catechins has not been previously conducted. So, purpose this work was study compare phytochemical composition, potential Vaccinium macrocarpon L., Ericaceae fruit thick Camellia sinensis Theaceae leaf liquid extracts. The quantification biologically active substances (BAS) accomplished with spectrophotometric, titrimetric HPLC methods analysis; determined by potentiometric method; anti-fungi effects evaluated well method minimum inhibition concentration. total content phenolic compounds 0.47% 10.10%, organic acids – 4.27% 1.60% for V. C. extract. extract 105,000 mg/kg, where epicatechin-3-O-gallate dominated (37300 mg/kg). 1280 peonidin-3-O-galactoside (408 Both possessed high potential, effective effects. antioxidant, higher than addition, we assumed that had properties catechins. These findings would promote application fruits as pharmaceuticals nutraceuticals.

Language: Английский

---

Synthesis and antimicrobial activities of unsymmetrical thioditetrazoles and their precursor thiotetrazoles

Organic Communications, Journal Year: 2023, Volume and Issue: 4, P. 204 - 211

Published: Oct. 29, 2023

In this study, a synthetic route to access unsymmetrical ditetrazoles was developed.By using method, the first examples of thioditetrazole compounds were synthesized.In vitro, antibacterial efficacy studies carried out for all thioditetrazoles and their precursor thiotetrazoles against ten bacteria.The synthesized showed strong effect pathogenic Gram-negative bacteria, especially Escherichia coli, Salmonella typhi Pseudomonas aeruginosa (up 23 mm).

Language: Английский

---

Chronic Inflammation and Chronic Diseases: Potential Healing with Glutathione‐Inspired Fragments

ChemistrySelect, Journal Year: 2022, Volume and Issue: 7(43)

Published: Nov. 16, 2022

Abstract Glutathione is one of the foremost human body antioxidant that enables him to cope with oxidative stress and its by‐products. This compound depleted by age, illness, viral infections, including Severe Acute Respiratory Syndrome infections (SARS). Restoring levels therefore crucial good health. Since oral bioavailability very poor, it important develop stable derivatives or fragments improved properties. The relationship between chronic inflammation, diseases widely documented. Compounds have high activities arouse much interest as they could contribute detrimental health conditions because stress, thus inflammation. We synthesized some interesting glutathione‐inspired from available starting materials assessed their power. Our compounds were analysed identified usual physicochemical spectroscopic techniques. Their activity was using Diphenylpicrylhydrazine radical Ferric Reducing Antioxidant Power assays. results showed IC 50 values ranging 1.35 mg/mL 3.40 mg/mL, among them (2.32 mg/mL) better than cysteine (IC =3.025 =3.03), which best precursor glutathione.

Language: Английский

---

Hepatoprotective, Antioxidant and Anti-inflammatory Actions of a Novel 5-Thiocyanauracil Compound and Ascorbic Acid against Paracetamol-Induced Hepatotoxicity in Female Rats

Journal of Pharmaceutical Negative Results, Journal Year: 2022, Volume and Issue: 13(SO3)

Published: Jan. 1, 2022

The 5-Thiocyanauracil (TCU) is a novel synthetic molecule that has been proposed for its hepatoprotective, antioxidant, and antiinflammatory action.Overdosing on paracetamol linked to hepatic damage, which major health danger, especially women.Our research's objective was determine the induced hepatic, anti-inflammatory, coagulopathy effects of against liver damage caused by in rats.Using fifty female rats (10 each group), following treatments were administered groups: Control (D.W or C) group, Paracetamol PA (500 mg/kg/day) TCU (50 mg/kg/day), & Ascorbic Acid (AA) (AA 50 PA+TCU group.For 25 days, given orally.Rats' hearts directly used draw blood samples.Prothrombin Time (PT) evaluated using an auto-analyzer (Huma Clot Jonior), whereas protein carboxylase (PC), Glutathione peroxidase (GPX), interleukin 6 (IL-6) detected serum homogenate ELISA method.TCU treatment dramatically increased GPX activity, decreased IL6 PC levels as compared PA.This finding supports ability reduce PT/INR trend undergo inhibit oxidation, inflammatory progressions over dosage.In conclusion, influenced potential hepatoprotective action could have partially attributed anti-inflammatory antioxidant properties addition tests PA-induced acute injury rat model.

Language: Английский

---