Synergistic effect of PS-MPs and Cd on male reproductive toxicity: Ferroptosis via Keap1-Nrf2 pathway
Yuzhi Lan,
No information about this author
Liehai Hu,
No information about this author
Xiaoyan Feng
No information about this author
et al.
Journal of Hazardous Materials,
Journal Year:
2023,
Volume and Issue:
461, P. 132584 - 132584
Published: Sept. 20, 2023
Language: Английский
A Review of in vivo Toxicity of Quantum Dots in Animal Models
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 8143 - 8168
Published: Dec. 1, 2023
Abstract:
Tremendous
research
efforts
have
been
devoted
to
nanoparticles
for
applications
in
optoelectronics
and
biomedicine.
Over
the
past
decade,
quantum
dots
(QDs)
become
one
of
fastest
growing
areas
nanotechnology
because
outstanding
photophysical
properties,
including
narrow
symmetrical
emission
spectrum,
broad
fluorescence
excitation
tenability
wavelength
with
particle
size
composition,
anti-photobleaching
ability
stable
fluorescence.
These
characteristics
are
suitable
optical
imaging,
drug
delivery
other
biomedical
applications.
Research
on
QDs
toxicology
has
demonstrated
affect
or
damage
biological
system
some
extent,
this
situation
is
generally
caused
by
metal
ions
special
properties
QDs,
which
hinders
further
application
field.
The
toxicological
mechanism
mainly
stems
from
release
heavy
generation
reactive
oxygen
species
(ROS).
At
same
time,
contact
reaction
also
cause
disorders
organelles
changes
gene
expression
profiles.
In
review,
we
try
present
an
overview
toxicity
related
mechanisms
different
target
organs.
It
believed
that
evaluation
synthesis
environmentally
friendly
primary
issues
be
addressed
future
widespread
However,
considering
many
types
potential
modifications,
review
still
not
clearly
elucidated,
needed
meaningful
topic.
Keywords:
dots,
nanotoxicology,
nanoparticle,
toxicity,
cytotoxic
Language: Английский
Distribution of Iron, Copper, Zinc and Cadmium in Glia, Their Influence on Glial Cells and Relationship with Neurodegenerative Diseases
Aleksandra Górska,
No information about this author
Agnieszka Markiewicz-Gospodarek,
No information about this author
Renata Markiewicz
No information about this author
et al.
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(6), P. 911 - 911
Published: June 5, 2023
Recent
data
on
the
distribution
and
influence
of
copper,
zinc
cadmium
in
glial
cells
are
summarized.
This
review
also
examines
relationship
between
those
metals
their
role
neurodegenerative
diseases
like
Alzheimer
disease,
multiple
sclerosis,
Parkinson
disease
Amyotrophic
lateral
which
have
become
a
great
challenge
for
today’s
physicians.
The
studies
suggest
that
among
cells,
iron
has
highest
concentration
oligodendrocytes,
copper
astrocytes
glia
hippocampus
cortex.
Previous
shown
neurotoxic
effects
manganese,
while
can
bidirectional
effect,
i.e.,
but
neuroprotective
depending
dose
state.
point
to
association
with
neurodegeneration
through
modulation
protein
aggregation.
Metals
accumulate
brain
aging
may
be
associated
age-related
diseases.
Language: Английский
Cadmium toxicity on endoplasmic reticulum functioning
Shivani Mishra,
No information about this author
Ramakrushna Paul,
No information about this author
Vibha Rani
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et al.
International Journal of Biochemistry and Molecular Biology,
Journal Year:
2024,
Volume and Issue:
15(4), P. 107 - 117
Published: Jan. 1, 2024
Cadmium
(Cd)
is
a
heavy
metal
pollutant
widely
distributed
in
the
environment
due
to
industrial
activities,
mining,
and
agricultural
practices.
Cadmium-induced
Toxicity
exerts
profound
effects
on
ER
functioning
through
multiple
mechanisms,
leading
cellular
dysfunction
pathological
consequences.
disrupts
protein
folding
activates
unfolded
response
(UPR).
Cd
exposure
leads
accumulation
of
misfolded
proteins,
triggering
UPR
pathways
mediated
by
critical
transmembrane
sensors:
IRE1,
PERK,
ATF6.
The
subsequent
aims
restore
homeostasis
but
can
also
induce
apoptosis
under
severe
stress
conditions.
calcium
inhibiting
SERCA
pump,
further
exacerbating
stress.
generation
reactive
oxygen
species
(ROS
plays
role
toxicity,
damaging
ER-resident
proteins
amplifying
activation).
affects
lipid
metabolism.
This
review
examines
mechanisms
which
toxicity
impairs
functioning,
disruption
quality
control
dysregulation
signaling
consequences,
including
oxidative
stress,
apoptosis,
inflammation,
are
discussed
context
Cd-induced
pathogenesis
diseases
such
as
Cancer
neurodegenerative
cardiovascular
disorders.
Finally,
potential
therapeutic
strategies
must
be
explored
mitigate
adverse
human
health.
Language: Английский
Screening of bioactive components in Ferula assafo dried oleo-gum resin and assessment of its protective function against cadmium-induced oxidative damage, genotoxicity, and cytotoxicity in rats
Toxicology Reports,
Journal Year:
2024,
Volume and Issue:
14, P. 101853 - 101853
Published: Dec. 12, 2024
Language: Английский
Future Perspectives on Cadmium Toxicity Research
Environmental science and engineering,
Journal Year:
2024,
Volume and Issue:
unknown, P. 523 - 531
Published: Jan. 1, 2024
Language: Английский
The comprehension of bioremediation for the isolation and characterization of heavy metal tolerant Aeromonas sanarellii bacteria in the wastewater-contaminated soil
Chidambaram Aravind,
No information about this author
Subhashini Sivaji,
No information about this author
Harashavardhan Nagaraj
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 12, 2023
Abstract
The
large
number
of
toxic
metals
accumulate
in
water
and
soil
environment
as
a
result
unmanaged
industrial
waste
disposal,
significantly
impacting
variety
health-related
issues.
Heavy
metal
resistance
is
very
high
among
microorganisms
the
soil's
rhizosphere.
In
this
work,
we
isolated
such
naturally
existing
rhizosphere
bacteria
Aeromonas
sanarellii
(
A.
)
from
heavily
contaminated
Anakaputhur
area,
southern
part
Chennai
city,
India.
On
basis
partial
amplification
16S
rRNA
using
new
primers,
was
molecularly
identified.
Then,
33
strains
were
used
to
align
sequence
order
study
phylogenetic
relationships
neighbour
joining
method.
This
assessed
its
ability
reducing
detoxifying
heavy
based
on
results
subsequent
testing.
effective
concentration
(EC
50
internationalization
determined
spectrophotometric
structural
changes
tolerant
studied
Scanning
electron
microscope
(SEM).
Protein
profiling
performed
SDS
PAGE
MALDI
TOF
analysis.
Amount
metallothionein
produced
upon
exposure
measured
by
UV-Vis
spectrophotometer.
found
that,
consequence,
selecting
their
biodegradation
could
serve
starting
point
for
developing
potential
bioremediation
agent
effluent
treatment
technology.
Language: Английский
Investigating the Effects of Salicylic Acid and Rice Husk Ash on Pb and Cd Concentration in Pinto Bean Plants Grown in Soil Contaminated with Diesel Oil and Heavy Metals
Journal of Human Environment and Health Promotion,
Journal Year:
2023,
Volume and Issue:
9(3), P. 138 - 145
Published: Sept. 1, 2023
Language: Английский