SuanZaoRen decoction alleviates neuronal loss, synaptic damage and ferroptosis of AD via activating DJ-1/Nrf2 signaling pathway

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 323, P. 117679 - 117679

Published: Dec. 29, 2023

SuanZaoRen Decoction (SZRD), a famous herbal prescription, and has been widely proven to have positive therapeutic effects on insomnia, depression Alzheimer's disease (AD). However, the anti-AD molecular mechanism of SZRD remains be further investigated.

Language: Английский

---

The Bioactivity and Phytochemicals of Muscari comosum (Leopoldia comosa), a Plant of Multiple Pharmacological Activities

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2592 - 2592

Published: Feb. 23, 2024

Leopoldia comosa (LC), popularly known as Muscari comosum, spontaneously grows in the Mediterranean region and its bulbs are used a vegetable. Traditionally, they also to treat various diseases conditions, which has inspired study of pharmacological activities different parts LC. These studies revealed numerous biological properties LC including antioxidant, anti-inflammatory, anti-diabetes, anti-obesity, anti-cancer, anti-Alzheimer's disease, antibacterial, immune stimulant. High antioxidant activity compared other non-cultivated plants, potential role reported make an excellent candidate be developed plant against important associated diseases. The presence diverse class phytochemicals (n = 85), especially flavonoids homoisoflavones, LC, imparts significance nutraceutical candidature plant. However, limited animal lack directional approach have further design effective clinical for development current is first attempt comprehensively compile information regarding emphasize targets/markers targeted by activities, highlight gaps propose possible bridges therapeutic and/or supplement

Language: Английский

---

Iron‐associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(1)

Published: Jan. 1, 2025

Abstract INTRODUCTION Iron‐mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer's disease (AD) pathology. While iron essential for basic biological functions, its reactivity generates oxidants which contribute to damage and death. METHODS To further resolve mechanisms iron‐mediated toxicity in AD, we analyzed post mortem human brain ApoEFAD mice. RESULTS AD brains had decreased antioxidant enzymes, including those mediated by glutathione (GSH). Subcellular analyses showed greater oxidative lower enzymes lipid rafts, the site amyloid processing, than non‐raft membrane fraction. Apolipoprotein E ε4 carriers raft yield with oxidation. The hypothesized role pathology was tested mice chelation deferoxamine, fibrillar peroxidation, together increased GSH‐mediated antioxidants. DISCUSSION These novel molecular pathways highlight rafts during AD. Highlghts have numerous markers ferroptosis, reduced levels, storage. Lipid cases enzyme levels activity are most severe apolipoprotein carriers. Neuronal correlated defense, signaling proteins suggesting that neuronal loss linked these events. Chelation early‐onset familial model reduces peroxidation amyloid.

Language: Английский

---

Targeting Ferroptosis/Nrf2 Pathway Ameliorates AlCl3-Induced Alzheimer’s Disease in Rats: Neuroprotective Effect of Morin Hydrate, Zeolite Clinoptilolite, and Physical Plus Mental Activities

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1260 - 1260

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is a significant health challenge in the 21st century. In spite of approval many new disease-modifying therapies for AD, clinical advantages these treatments are less certain. Aim: This investigation was intended to determine potential neuroprotective impact morin hydrate (MH), zeolite clinoptilolite (ZC), and/or physical and mental activities (PhM) on an aluminum chloride (AlCl3)-induced AD rat model. Methods: Male Sprague Dawley rats were randomly allocated into seven groups. Group I control group. Groups II–VII treated with AlCl3 5 weeks. III–VII tested effects MH, ZC, PhM. Biochemical, brain histopathological, behavioral studies performed. Results: PhM, ZC combined therapy exhibited effect demonstrated by corrected catecholamines tau β-amyloid levels, as well antioxidant anti-ferroptotic probably through Nrf2/HO-1/GPX4 ACSL4 signaling pathways. addition, counteracted inflammatory responses modulating TLR4/NF-κβ/NLRP3 inflammasome expression. Moreover, groups showed maximum improvement both APOE4/LRP1 Wnt3/β-catenin/GSK-3β expressions. Conclusion: research highlights MH plus PhM against AlCl3-induced via modulation Nrf2/HO-1/GPX4, TLR4/NF-κβ/NLRP3, APOE4/LRP1, It first point out inclusion ferroptosis-Nrf2/inflammasomes cross-talk neuroprotection mechanism MH/ZC AlCl3-mediated

Language: Английский

---

Korean Black Ginseng Extract Alleviates Alzheimer’s Disease-Related Cognitive Impairment by Activating the Nrf2/HO-1 Pathway and Suppressing the p38 MAPK/NF-κB/STAT3 Pathways and NLRP3 Inflammasome via TLR2 and TLR4 Modulation

Journal of Ginseng Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

---

Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer’s disease

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: March 28, 2025

Language: Английский

---

The effects of weight training and Aklil-ol-Malek on histopathology and C-Reactive Protein, Nuclear Factor Erythroid-Derived 2-Like 2Beta-Site Amyloid Precursor Protein Cleaving Enzyme1 genes Expression in Alzheimer’s disease model rats

Journal of Neurorestoratology, Journal Year: 2025, Volume and Issue: unknown, P. 100206 - 100206

Published: April 1, 2025

Language: Английский

---

Bulbils of Aerial Yam Attenuate Ethanol-Induced Hepatotoxicity in HepG2 Cells through Inhibition of Oxidative Stress by Activation of the Nuclear Factor Erythroid-2-Related Factor 2 Signaling Pathway

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 542 - 542

Published: Feb. 16, 2024

Bulbil of yam (BY) extract contains various active compounds possessing many pharmacological properties. However, little is known about the effect and underlying mechanism BY on ethanol-induced liver damage. The present study explored beneficial potential hepatotoxicity. To evaluate its effectiveness, HepG2 cells were pretreated with extract. effectively rescued from ethanol treatment through inhibition apoptotic cell death as well inhibiting expression mitogen-activated protein kinase (MAPK) proteins stress inducers. increased typical antioxidants. Furthermore, significantly inhibited mitochondrial dysfunction endoplasmic reticulum (ER) stress, which are major ROS-inducing factors. Finally, an protective effects damage, it activated Nrf2 translocation cytosol to nucleus, in turn target oxidative suppressor genes. Collectively, our findings demonstrate that has antioxidative contributes establishment a strategy for alcohol-derived injuries.

Language: Английский

---

Sleep restriction promotes brain oxidative stress and inflammation, and aggravates cognitive impairment in insulin-resistant mice

Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 166, P. 107065 - 107065

Published: April 29, 2024

Language: Английский

---

Effects of Cycloastragenol on Alzheimer's Disease in Rats by Reducing Oxidative Stress, Inflammation, and Apoptosis

Current Alzheimer Research, Journal Year: 2024, Volume and Issue: 21(2), P. 141 - 154

Published: Feb. 1, 2024

Background: As individuals age, they may develop Alzheimer's disease (AD), which is characterized by difficulties in speech, memory loss, and other issues related to neural function. Cycloastragenol an active ingredient of Astragalus trojanus has been used treat inflammation, aging, heart disease, cancer. Objectives: This study aimed explore the potential therapeutic benefits cycloastragenol rats with experimentally induced AD. Moreover, underlying molecular mechanisms were also evaluated measuring Nrf2 HO-1, are involved oxidative stress, NFκB TNF-α, BCL2, BAX, caspase-3, apoptosis. Methods: Sprague-Dawley given 70 mg/kg aluminum chloride intraperitoneally daily for six weeks induce Following AD induction, 25 oral gavage three weeks. Hippocampal sections stained hematoxylin/ eosin anti-caspase-3 antibodies. The Nrf2, NFκB, caspase-3 gene expressions protein levels samples analyzed. Results: significantly improved rats' behavioral test performance. It strengthened organization hippocampus. performance hippocampal structure rats. caused a marked decrease expression was associated increase HO-1. Conclusion: hippocampus enhanced outcomes tests, decreased concentration AChE brain, exerted antioxidant anti-inflammatory effects. Antiapoptotic effects noted, leading significant improvements cognitive function, memory, behavior treated

Language: Английский

---