Novel Targeted Therapies for Rheumatoid Arthritis Based on Intracellular Signalling and Immunometabolic Changes: A Narrative Review

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(1), P. 42 - 42

Published: Jan. 23, 2024

Rheumatoid arthritis (RA) is a relatively common systemic autoimmune disease with an estimated prevalence of approximately 1% worldwide. Patients present predominantly symmetrical small joint inflammatory arthritis, which involves dysregulated immune responses, leading to bone and cartilage deformities due extensive erosive damage. The introduction biological based therapies for the management this life-altering condition, over past three decades, has led marked improvements in patients’ quality life. A wide range both innate adaptive cells are involved pathogenesis RA, complex interplay cytokines, T-cells, B-cells, dendritic cells. Some these have been successfully targeted treatment RA by use biologics-based therapies. For example, rituximab therapy blocks B cell activation abatacept effectively T patients RA. Despite advances, there remain some who resistant all current therapeutic options, encouraged further research into understanding primary signal transduction pathways that mediate disease. In review we discuss roles main signalling pathways, including metabolic reprogramming implicated progression, order develop conceptual framework more precise deployment existing therapies, provide rationale producing molecular inhibitors pathways. Improved knowledge many intracellular will complement precision medicine strategies, particularly difficult-to-treat especially those multidrug resistance

Language: Английский

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Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors

Current Genomics, Journal Year: 2023, Volume and Issue: 24(3), P. 136 - 145

Published: May 1, 2023

Epigenetic changes play an important role in the pathophysiology of autoimmune diseases such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis, atherosclerosis, rheumatoid arthritis, and COVID-19. There are three main classes epigenetic alterations: post-translational modifications histone proteins, control by non-coding RNA DNA methylation. Since can directly affect chromatin structure accessibility, they regulate gene expression levels. Abnormal activity deacetylases (HDACs) have been reported immune mediated diseases. Increased acetylated levels lysine residues suggested to be related overexpression inflammatory genes. This review focuses on effect HDAC non-histone proteins Furthermore, we discuss potential therapeutic inhibitors (HDACi) used these

Language: Английский

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Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106473 - 106473

Published: Sept. 21, 2024

Language: Английский

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Circulating MicroRNAs and Cytokines Associated with Celiac Disease

Middle East Journal of Digestive Diseases, Journal Year: 2024, Volume and Issue: 16(3), P. 185 - 192

Published: July 31, 2024

The current research examines the molecular terrain of celiac disease (CD) through microRNA (miRNA) and cytokines as potential new diagnostic therapeutic markers. Gluten-appropriate immune response is a key feature an autoimmune clinical entity known CD that leads to inflammation degeneration small intestine mucosa. However, mechanisms responsible for this remain unclear.

Language: Английский

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Psychoemotional response and quality of life of patients with rheumatoid arthritis: the relationship with alexithymia

Reports of Vinnytsia National Medical University, Journal Year: 2024, Volume and Issue: 28(1), P. 80 - 84

Published: March 14, 2024

Annotation. In aim to study the features of psycho-emotional response and quality life rheumatoid arthritis (RA) patients in context alexithymia, 146 RA were examined using DAS-28, SDAI, CDAI, VAS, HAQ, DRI, TAS-20, HDRS, HARS, A. Beck SF-36. showed signs mild depression (HRDS score 9.59±7.09 points, scale 10.04±15.00 points), alexithymia moderate severity (16.72±5.79 points 17.31±14.60 without – subdepression (7.25±5.82 7.66±14.41 points); increased level anxiety (HARS 17.07±7.08 while with had a significantly higher compared (20.08±5.86 versus 16.08±7, 19 p<0.01). Correlations strength established between clinical symptoms disease; moreover, these connections distorted, which gives reason consider as factor that distorts pathophysiological psychopathological reactions, somatic psychological factors pathogenesis RA. RA, decrease was found, more significant according physical component health (indicators all 53.05±19.36 35.69±14.19 58.73±17.38 p<0.001) (57.84±18.02 34.78±8.79 65.38±13.19 respectively, p<0.001). Significant (p<0.001) inverse correlations mainly indicators activity, pain syndrome, functional capacity status patients, well TAS-20 indicators, scales absence relationships for most indicates influence on

Language: Английский

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High Humidity Aggravates Collagen-induced Arthritis in Mice by Increasing the Expression of Splenic Myeloid-derived Suppressor Cells

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 15, 2024

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and bone destruction, leading to severe complications. Previous research has suggested that high humidity conditions may exacerbate RA, but the underlying mechanisms remain unclear. Furthermore, there a lack of evidence linking worsening RA symptoms in animal models. Methods: We utilized C57BL/6 mice establish CIA mouse model. The status was assessed under two different humidities (50% 80%). ELISA used measure concentrations autoantibodies pro-inflammatory factors. Histopathological changes spleen tissues were observed through H&E immunohistochemistry. Mass cytometry employed investigate cell types spleens conditions. Additionally, we evaluated oxidative stress markers associated with MDSCs conducted mRNA sequencing sorted their impact on mice. Results: Compared normal humidity, exacerbated incidence mice, increased scores,swelling, serum (anti-COII anti-CCP), upregulation cytokines. Significant variations index accompanied noticeable inflammatory alterations. Elevated levels induced substantial modulation population along alterations such as heightened ROS levels, expression COX, SOD, Nrf2 mRNA. Following successful sorting MDSCs, revealed decrease Rap1 signaling pathway environment, which contribute increase cells aggravate progression disease. Conclusion: Our comprehensive analysis demonstrates negative factor occurrence development potentially mediated influence MDSCs.

Language: Английский

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FOXA2 inhibits the TLR4/NF-κB signaling pathway and alleviates inflammatory activation of macrophages in rheumatoid arthritis by repressing LY96 transcription

Cytokine, Journal Year: 2024, Volume and Issue: 184, P. 156796 - 156796

Published: Nov. 1, 2024

Rheumatoid arthritis (RA) remains a devastating autoimmune disease characterized by joint damage, inflammation, and disability. This study investigates the function of lymphocyte antigen 96 (LY96) in inflammatory response RA explores its regulatory mechanism.

Language: Английский

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High Humidity Alters Myeloid-Derived Suppressor Cells in Spleen Tissue: Insights into Rheumatoid Arthritis Progression

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9805 - 9822

Published: Nov. 1, 2024

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and bone destruction, leading to severe complications. Previous research has suggested that high humidity conditions may exacerbate RA, however, the underlying mechanisms remain unclear. Furthermore, there a lack of evidence linking worsening RA symptoms in animal models.

Language: Английский

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