Problems of Biological Medical and Pharmaceutical Chemistry,
Journal Year:
2023,
Volume and Issue:
unknown, P. 64 - 70
Published: Dec. 17, 2023
The
objective
of
the
study
was
to
assess
serum
and
urinary
concentrations
essential
trace
elements
in
women
with
osteoporosis.
Material
methods.
A
total
100
aged
30-70
years
old
including
50
patients
osteoporosis
(ICD-10:
M81)
healthy
controls
were
examined.
Assessment
element
levels
performed
using
inductively-coupled
plasma
mass-spectrometry.
Results.
obtained
data
demonstrate
that
cobalt
zinc
42%
44%
lower
than
those
control
women.
Analysis
covariance
demonstrated
a
significant
impact
body
mass
index
(BMI)
values
on
Zn
concentra-tion.
influence
presence
Co
concentration
nearly
significant.
At
same
time,
os-teoporotic
21%
controls,
while
no
difference
observed.
osteopo-rosis
examined
also
considered
key
factor
affecting
independently
age
BMI
values.
Conclusion.
Therefore,
results
present
association
between
deficiency
It
is
suggested
personalized
correction
burden
these
may
reduce
risk
due
osteogenic
effect
cobalt.
intimate
mechanisms
this
association,
as
well
efficiency
supplementation
strategies
manage-ment
requires
further
investigation.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
488, P. 150631 - 150631
Published: March 26, 2024
The
skeletal
system
is
essential
for
preserving
body
structure
and
facilitating
mobility;
however,
bone
diseases
frequently
result
in
significant
disabilities,
necessitating
the
investigation
into
biomaterials
restoration.
Nevertheless,
these
may
elicit
immune
reactions
that
obstruct
healing
process.
Macrophages
assume
a
pivotal
role
modulating
inflammation
sustaining
homeostasis
regeneration.
A
comprehensive
understanding
of
molecular
interactions
between
macrophages
imperative
development
sophisticated
designed
to
regulate
environment
promote
remodeling.
This
review
delves
generation,
polarization,
interaction
with
principal
cell
types
implicated
osteogenesis,
detailing
mechanisms
by
which
influence
repair
their
response
biomaterials.
Additionally,
it
discusses
strategies
precise
modulation
macrophage
functionality
via
intelligent
mechanisms,
outlines
challenges
constraints
designing
integrate
functions.
By
elucidating
challenges,
lays
groundwork
creation
advanced
endowed
smart
immunomodulatory
capabilities,
heralding
novel
approaches
treatment
defects
advancement
regeneration
therapies.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Diabetic
osteoporosis
(DOP)
is
a
chronic
complication
of
diabetes
mellitus
(DM)
that
impairs
bone
health,
and
effective
management
DOP
remains
formidable
challenge.
In
this
study,
we
developed
biocatalytic
cascade
nanoplatform,
GOx@SrCaP-CAT-Tet,
offering
osteogenic,
angiogenic,
anti-inflammatory
activities
for
targeted
management.
The
platform
includes
glucose
oxidase
(GOx)
catalase
(CAT),
encapsulated
in
strontium-doped
calcium
phosphate
(SrCaP),
converting
into
gluconic
acid
hydrogen
peroxide
(H2O2),
alleviating
the
hyperglycemia
promoting
hypoxia-induced
vascularization.
Both
generated
H2O2
any
overabundance
microenvironment
can
be
scavenged
by
CAT,
thus
relieving
inflammation.
Via
surface
modified
with
tetracycline
(Tet)
targeting,
release
Sr2+,
Ca2+,
PO43-
stimulate
osteogenesis
suppress
osteoclastogenesis,
thereby
hastening
formation
reversing
osteoporosis.
This
nanoplatform
shows
promise
managing
both
vitro
vivo.
Our
findings
open
new
horizon
through
reactions.
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(3), P. 250 - 250
Published: Jan. 22, 2025
Background:
Osteogenesis
imperfecta
(OI)
is
a
rare
monogenic
connective
tissue
disorder
characterized
by
fragility
of
bones
and
recurrent
fractures.
In
addition
to
the
hereditary
component,
there
are
number
factors
that
influence
course
disease,
contribution
which
poorly
understood,
in
particular
levels
micronutrients.
Methods:
A
cross-sectional
study
was
conducted
involving
45
with
OI
healthy
individuals.
The
concentrations
micronutrients
(calcium,
copper,
inorganic
phosphorus,
zinc,
magnesium)
bone
mineral
density
(BMD)
were
evaluated
all
participants.
Results:
groups
within
reference
values.
overall,
magnesium
copper
elevated,
phosphorus
zinc
lower.
Type
I
exhibited
higher
lowest
phosphorus;
type
III
associated
lower
IV
calcium
V
phosphorus.
overall
BMD
correlational
analysis
group
showed
fractures
correlated
absolute
values
but
not
Z-score.
Conclusions:
obtained
data
emphasize
importance
pathogenesis
diseases,
OI.
As
results
previous
studies,
population
norm,
probably
requires
development
individual
criteria
for
content
substances
this
category
patients.
BMC Public Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 19, 2025
Both
osteoporosis
and
metal
exposure
are
well-recognized
public
health
concerns
globally,
particularly
in
the
aging
population.
However,
studies
investigating
relationship
between
bone
conditions
such
as
osteopenia
have
either
produced
inconsistent
results
or
scarce,
especially
among
ethnic
minorities
China.
Herein,
we
correlated
single-metal
mixture
with
using
a
log-binomial
regression
model
quantile
g-computation.
In
total,
9,206
Chinese
individuals
(Dong
Miao)
aged
30–79
years
were
investigated
this
study
utilizing
baseline
data
from
multi-ethnic
cohort
study.
model,
urinary
concentrations
of
arsenic
(As),
cadmium
(Cd),
chromium
(Cr),
iron(Fe),
mercury(Hg),
manganese
(Mn)
positively
associated
osteopenia,
whereas
those
cobalt(Co)
zinc(Zn)
negatively
associated.
Additionally,
As,
Cd,
Cr,
Mn
osteoporosis,
that
vanadium(V)
was
Furthermore,
Quantile
g-computation
indicated
both
osteoporosis.
Altogether,
these
findings
suggest
simultaneous
to
multiple
metals
can
affect
health,
providing
theoretical
basis
for
further
on
underlying
complex
mechanisms.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Abstract
Bone
tissues
are
densely
innervated
by
nerve
fibers
throughout
the
periosteum
and
mineralized
bone.
The
impairment
of
bone
regeneration
is
a
critical
factor
contributing
to
challenges
in
osteoporotic
remodeling
repair.
Herein,
an
“ultrasound‐driven
regeneration”
strategy
proposed
additively
manufactured
degradable
Zn‐Cu
scaffolds.
vitro
investigations
with
RSC96
cells
elucidated
synergistic
promotion
low‐intensity
pulsed
ultrasound
(LIPUS)
metal
cations
on
Schwann
cell
proliferation
exosome
secretion.
Notably,
these
cell‐derived
exosomes,
once
internalized
neighboring
marrow
stromal
(BMSCs),
significantly
enhanced
their
migration,
osteogenic
differentiation,
extracellular
matrix
deposition,
indicating
potent
mechanism
for
regeneration.
Furthermore,
vivo
evaluation
validated
that
LIPUS
stimulation
activated
S100β‐positive
facilitated
peripheral
within
cranial
defects,
leading
accelerated
healing
rats
implantation
over
2‐
6‐week
recovery
periods.
This
work
provides
focusing
activation
enhancement
paracrine
effect,
especially
secretion,
which
further
recruited
surrounding
BMSCs
promoted
differentiation.
study
holds
considerable
promise
clinical
applications
translation
treatment
defects.
Genes,
Journal Year:
2025,
Volume and Issue:
16(5), P. 475 - 475
Published: April 23, 2025
Background/Objectives:
According
to
the
International
Classification
of
Hereditary
Skeletal
Diseases
(2019),
osteogenesis
imperfecta
(OI)
is
classified
as
a
disorder
resulting
from
impaired
formation
cortical
layer
density
diaphyses
and
metaphyseal
modeling.
OI
comprises
heterogeneous
group
genetic
diseases,
with
most
cases
inherited
in
an
autosomal
dominant
manner,
while
others
follow
recessive
or
X-linked
inheritance
patterns.
Accurate
DNA
testing
essential
for
precise
medical
counseling,
ensuring
reliable
prognostic
assessments
patients’
descendants
siblings.
As
part
study
population
Republic
North
Ossetia
Alania,
specifically
Mozdok
district,
specialists
Laboratory
Genetic
Epidemiology
at
Research
Centre
Medical
Genetics
(RCMG)
examined
family
13
affected
individuals
across
four
generations.
Methods:
A
comprehensive
clinical
assessment
was
performed,
followed
by
molecular
analysis
using
whole-exome
sequencing
(WES).
Segregation
within
conducted
via
Sanger
sequencing.
Results:
Clinical
evaluation
suggested
diagnosis
OI,
which
subsequently
confirmed
testing.
The
severity
spectrum
symptoms
varied
considerably
among
members
were
influenced
age
specific
nuclear
lineage.
Molecular
proband
identified
heterozygous
pathogenic
variant
COL1A1
gene
(c.1243C>T,
p.(Arg415*)),
confirming
type
IV.
found
co-segregate
disease
family.
Conclusions:
enabled
risk
offspring
mild
phenotypic
manifestations.
Additionally,
pediatric
patients
referred
standard
bisphosphonate
therapy
manage
condition
effectively.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(3), P. 274 - 274
Published: Feb. 22, 2024
Olive
leaves
are
consumed
as
an
extract
or
a
whole
herbal
powder
with
several
potential
therapeutic
benefits
attributed
to
polyphenols,
tocopherol’s
isomers,
and
flavonoids,
among
others.
This
study
assessed
the
variance
in
functional
features
presented
by
olive
from
three
different
Portuguese
cultivars—Cobrançosa,
Madural,
Verdeal—randomly
mix-cultivated
geographical
area
of
Vale
de
Salgueiros.
Inorganic
analysis
determined
their
mineral
profiles
while
organic
measured
total
phenolic
flavonoid
content,
scanned
tocopherol
fatty
acid
composition.
The
extracts’
biological
activity
was
tested
determining
antimicrobial
antioxidant
power
well
ability
inhibit
acetylcholinesterase,
butyrylcholinesterase,
MAO-A/B,
angiotensin-I-converting
enzyme.
inorganic
showed
them
be
inexpensive
source
able
address
deficiencies.
All
cultivars
appear
have
for
use
possible
antioxidants
future
alternative
antibiotics
against
some
multidrug-resistant
microorganisms,
caution
regarding
arsenic
content
Verdeal
cultivar.
Madural’s
displayed
properties
considered
natural
multitarget
treatment
Alzheimer’s
Parkinson’s
diseases,
depression,
cardiometabolic
dual
blood
pressure
modulation.
work
indicates
that
randomly
cultivating
significantly
modifies
leaves’
composition
keeping
multifaceted
value.
