Antioxidant Enzyme Activities, Total Sialic Acid, Vitamin, and Trace Element Status in the Patient with Osteoporosis and Osteopenia

Deleted Journal, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 12, 2024

In this study, osteoporosis (OS), osteopenia (OP), postmenopausal women with (PMOS) and (PMOP), control participants were evaluated for erythrocyte. CAT, GSH-Px, SOD enzyme activities, MDA, GSH, serum phylloquinone, cholecalciferol, retinol, α-tocopherol, TSA, TAS, Co, Mn, Fe, Zn, Cu, Se, Ni, Cd, Pb, Mg, Ca, P, K, Cl levels, the relations of parameters (F-L-BMD, LT-FT-score) assessed. element analyses carried out using ICP-OES vitamin determination HPLC method. Statistical showed that OS group had significantly lower FBMD (p < 0.001), LBMD GSH 0.01), GSH-Px CAT α-tocopherol 0.05), retinol cholecalciferol phylloquinone Se Fe Cu Co Zn Mg 0.01) levels than group. However, 0.05) MDA are higher It was revealed there is a significant correlation between Mn–L BMD (r = 0.426; p 0.024), retinol–L 0.502; 0.007), cholecalciferol–L − 0.520; 0.005), OP; also 0.607; 0.008) PMOS; K–F 0.504; 0.009), Co–LT score 0.432; 0.031) PMOP. Our study demonstrates Mn increased OSI K related to decreased L F status oxidative stress in OP, PMOS, A deficiency can be risk factor progression OS, PMOP could have negative effect on bone density.

Language: Английский

---

Disentangling the Relationship Between Urinary Metal Exposure and Osteoporosis Risk Across a Broad Population: A Comprehensive Supervised and Unsupervised Analysis

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 866 - 866

Published: Nov. 28, 2024

Background: Limited evidence links urinary metal exposure to osteoporosis in broad populations, prompting this study cover knowledge gap using supervised and unsupervised approaches. Methods: This included 15,923 participants from the National Health Nutrition Examination Survey (NHANES) spanning 1999 2020. Urinary concentrations of nine metals—barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (Tl), tungsten (Tu)—were measured inductively coupled plasma mass spectrometry (ICP-MS). Osteoporosis was assessed via dual-energy X-ray absorptiometry. A weighted quantile sum (WQS) regression analysis evaluated each metal’s contribution risk. Partitioning around medoids (PAM) clustering identified high- low-exposure groups, their association with risk prognosis evaluated. Results: WQS Cd as a significant factor general population (odds ratio (OR) = 1.19, 95% confidence interval (CI): 1.08, 1.31, weight 0.66). Pb notably affected those individuals aged 30–49 years classified Mexican American, while Sb impacted Black individuals. PAM showed that high-exposure group had significantly higher (OR 1.74, CI: 1.43, 2.12) cumulative mortality Conclusions: metals are associated osteoporosis.

Language: Английский

---

Metal mixture exposure and the risk of osteopenia or osteoporosis: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 6, 2023

Abstract Osteoporosis is emerging as a growing public health concern worldwide due to the aging population, and metal exposure widely recognized risk factor for human health. However, studies on relationship between bone yield inconsistent results. Limited epidemiological research exists associations of mixtures with osteopenia osteoporosis, particularly among ethnic minorities in China. We conducted study 9206 Chinese (Dong Miao) aged 30–79 years using data from Multi-Ethnic Cohort Study (CMCS) baseline survey database. utilized inductively coupled plasma mass spectrometry (ICP-MS) measure concentrations 11 metals urine quantitative ultrasound mineral density (BMD). Multivariate logistic regression model, Quantile g-computation Principal component analysis were used explore correlation single-metal mixture osteoporosis. In urinary As, Cd, Cr, Fe, Hg Mn positively associated osteopenia. Conversely, Co Zn negatively Urinary Cr while V was addition, g-comptation showed that identified principal 1, characterized by Fe Mn, 3, These findings suggest co-exposure polymetals affects occurrence development warranting further investigation into complex mechanisms involved.

Language: Английский

---

The paradoxical role of zinc on microglia

Journal of Trace Elements in Medicine and Biology, Journal Year: 2023, Volume and Issue: 83, P. 127380 - 127380

Published: Dec. 28, 2023

Language: Английский

---

THE LEVELS OF ESSENTIAL TRACE ELEMENTS IN BLOOD SERUM AND URINE OF WOMEN WITH OSTEOPOROSIS

Problems of Biological Medical and Pharmaceutical Chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 64 - 70

Published: Dec. 17, 2023

The objective of the study was to assess serum and urinary concentrations essential trace elements in women with osteoporosis. Material methods. A total 100 aged 30-70 years old including 50 patients osteoporosis (ICD-10: M81) healthy controls were examined. Assessment element levels performed using inductively-coupled plasma mass-spectrometry. Results. obtained data demonstrate that cobalt zinc 42% 44% lower than those control women. Analysis covariance demonstrated a significant impact body mass index (BMI) values on Zn concentra-tion. influence presence Co concentration nearly significant. At same time, os-teoporotic 21% controls, while no difference observed. osteopo-rosis examined also considered key factor affecting independently age BMI values. Conclusion. Therefore, results present association between deficiency It is suggested personalized correction burden these may reduce risk due osteogenic effect cobalt. intimate mechanisms this association, as well efficiency supplementation strategies manage-ment requires further investigation.

Language: Английский

---