Can interventions targeting MDSCs improve the outcome of vaccination in vulnerable populations? DOI
Yuliya V. Perfilyeva, Arthur Aquino,

M Borodin

et al.

International Reviews of Immunology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Dec. 21, 2024

Preventive vaccination is a crucial strategy for controlling and preventing infectious diseases, offering both effectiveness cost-efficiency. However, despite the widespread success of programs, there are still certain population groups who struggle to mount adequate responses immunization. These at-risk include but not restricted elderly, overweight individuals, individuals with chronic infections cancer patients. All these characterized by persistent inflammation. Recent studies have demonstrated that one key players in immune regulation promotion inflammation myeloid-derived suppressor cells (MDSCs). possess wide range immunosuppressive mechanisms able dampen antigen-specific antigen-nonspecific manner, thus contributing establishment maintenance an inflammatory environment. Given their pivotal role modulation, growing interest understanding how MDSCs may influence efficacy vaccines, particularly vulnerable populations. In this narrative review, we discuss whether regulate vaccine-induced immunity suppression can potentially enhance vaccine

Language: Английский

Mechanisms and Strategies of Immunosenescence Effects on Non-Small Cell Lung Cancer (NSCLC) Treatment: A Comprehensive Analysis and Future Directions DOI
Huatao Zhou,

Zilong Zheng,

Chengming Fan

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 109, P. 44 - 66

Published: Jan. 9, 2025

Language: Английский

Citations

3
Integrins in Health and Disease—Suitable Targets for Treatment? DOI Creative Commons

Tanja Klaus,

Christoph Hieber,

Matthias Bros

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(3), P. 212 - 212

Published: Jan. 23, 2024

Integrin receptors are heterodimeric surface that play multiple roles regarding cell–cell communication, signaling, and migration. The four members of the β2 integrin subfamily composed an alternative α (CD11a–d) subunit, which determines specific receptor properties, a constant β (CD18) subunit. This review aims to present insight into immunological receptors, with focus on integrins specifically expressed by leukocytes. pathophysiological role is confirmed drastic phenotype patients suffering from leukocyte adhesion deficiencies, most often resulting in severe recurrent infections and, at same time, predisposition for autoimmune diseases. So far, studies vivo employed mice constitutive knockout all or either family member, respectively, complicated differentiation between direct indirect effects deficiency distinct cell types. recent generation characterization transgenic cell-type-specific knockdown our group has enabled dissection cell-specific integrins. Further, have been recognized as target treatment inflammatory diseases well tumor therapy. However, whereas both agonistic antagonistic agents yielded beneficial animal models, success clinical trials was limited cases associated unwanted side effects. unfavorable outcome probably related systemic used compounds leukocytes, thereby emphasizing need develop formulations types leukocytes modulate activity therapeutic applications.

Language: Английский

Citations

4
Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review DOI Creative Commons

Lichang Yang,

Wei Wu, Jing Yang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 28, 2025

Immunosenescence, the age-associated decline of immune system, is pivotal in fostering drug resistance within tumor microenvironment (TME). The accumulation senescent cells and release pro-inflammatory senescence-associated secretory phenotype (SASP) factors create a milieu that supports survival undermines therapeutic efficacy. Traditional cancer treatments often fail to address this underlying issue, leading suboptimal outcomes. This article proposes an innovative strategy overcome immunosenescence-induced through nanoparticle-mediated delivery herbal-derived natural products (HDNPs), which possess senolytic immunomodulatory properties capable clearing rejuvenating function. Nanoparticle systems enhance these compounds' stability, bioavailability, targeted TME cells. By harnessing synergistic effects HDNPs nanotechnology, approach offers novel multifaceted solution therapy. It holds potential restore surveillance, reduce pro-survival signaling cells, efficacy conventional treatments. paradigm shift emphasizes importance addressing immunosenescence as target paves way for more effective personalized interventions.

Language: Английский

Citations

0
T-Cell Senescence: Unlocking the Tumor Immune “Dark Box” - A Multidimensional Analysis from Mechanism to Tumor Immunotherapeutic Intervention DOI
Jia Cheng, Jian Zheng, Man Chen

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
New insights for the development of efficient DNA vaccines DOI Creative Commons
Simone Berger, Yanira Zeyn, Ernst Wagner

et al.

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(11)

Published: Nov. 1, 2024

Abstract Despite the great potential of DNA vaccines for a broad range applications, ranging from prevention infections, over treatment autoimmune and allergic diseases to cancer immunotherapies, implementation such therapies clinical is far behind expectations up now. The main reason poor immunogenicity in humans. Consequently, improvement performance vivo required. This mini‐review provides an overview current state various strategies enhance immunogenic vaccines, including (i) optimization construct itself regarding size, nuclear transfer transcriptional regulation; (ii) use appropriate adjuvants; (iii) improved delivery, example, by careful choice administration route, physical methods as electroporation nanomaterials that may allow cell type‐specific targeting. Moreover, combining nanoformulated with other immunotherapies prime‐boost help success treatment.

Language: Английский

Citations

2
Young age and adequate BCG are key factors for optimal BCG treatment efficacy in non-muscle-invasive bladder cancer DOI Creative Commons
Kang Liu,

Rossella Nicoletti,

Hongda Zhao

et al.

World Journal of Urology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Sept. 27, 2024

Language: Английский

Citations

1
Accelerated Aging and the Life Course of Individuals Born Preterm DOI Creative Commons
A. Bousquet, Keia Sanderson, T. Michael O’Shea

et al.

Children, Journal Year: 2023, Volume and Issue: 10(10), P. 1683 - 1683

Published: Oct. 13, 2023

Individuals born preterm have shorter lifespans and elevated rates of chronic illness that contribute to mortality risk when compared individuals at term. Emerging evidence suggests or low birthweight also exhibit physiologic cellular biomarkers accelerated aging. It is unclear whether, what extent, aging contributes a higher among preterm. Here, we review phenotypes in adults biological pathways appear We highlight various resiliency factors, including both pharmacologic non-pharmacologic might buffer the propensity for

Language: Английский

Citations

3
Rapport 23-25. Vaccination des seniors DOI Creative Commons
Yves Buisson,

P Bègué,

Jean‐Pierre Michel

et al.

Bulletin de l Académie Nationale de Médecine, Journal Year: 2023, Volume and Issue: 208(2), P. 131 - 141

Published: Dec. 14, 2023

Citations

1
Chronic immune activation and accelerated immune aging among HIV-infected adults receiving suppressive antiretroviral therapy for at least 12 years in an African cohort DOI Creative Commons
Damalie Nakanjako, Rose Nabatanzi, Isaac Ssinabulya

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31910 - e31910

Published: May 24, 2024

HIV-associated alterations innate and adaptive immune cell compartments are reminiscent of the process aging.

Language: Английский

Citations

0
PD-1+ T lymphocyte proportions and hospitalized exacerbation of COPD: a prospective cohort study DOI Creative Commons
Hong Xue, Xiuyan Lan, Ting Xue

et al.

Respiratory Research, Journal Year: 2024, Volume and Issue: 25(1)

Published: May 24, 2024

To evaluate the predictive value of PD-1 expression in T lymphocytes for rehospitalization due to acute exacerbations COPD (AECOPD) discharged patients. 115 participants hospitalized with (average age 71.8 ± 6.0 years) were recruited at Fujian Provincial Hospital. PD1+T proportions (PD1+T%), baseline demographics and clinical data recorded hospital discharge. AECOPD re-admission collected 1-year follow-up. Kaplan-Meier analysis compared time readmissions among groups stratified by PD1+T%. Multivariable Cox proportional hazards regression determined correlation between PD1+T%, potential confounders, re-admission. ROC DCA evaluated PD1+T% enhancing values models, BODE CODEX. 68 (59.1%) readmitted, those readmission exhibited significantly elevated PD-1+CD4+T/CD4+T% PD-1+CD8 + T/CD8 T% non-readmitted counterparts. PD1+ lymphocyte levels statistically correlated CODEX indices. demonstrated that Higher had reduced (logRank p < 0.05). identified high PD1+CD4+T PD1+CD8+T ratios as risk factors readmission, hazard 1.384(95%CI [1.043-1.725]) 1.401(95%CI [1.013-1.789]), respectively. Notably, patients aged 70 years fewer than twice episodes previous year, counts increased readmission(p The model, incorporating superior discrimination index index, AUC 0.763(95%CI [0.633-0.893]) 0.734(95%CI [0.570-0.899]) (DeLong's test 0.05).The illustrates integrating into models enhances utility aiding decision-making. Evaluation offer a novel perspective identifying high-risk patients, potentially providing insights management. Chinese Clinical Trial Registry (ChiCTR, URL: www.chictr.org.cn/ ), Registration number: ChiCTR2200055611 Date Registration: 2022-01-14.

Language: Английский

Citations

0