Ginsenosides Rg1, Rb1 and rare ginsenosides: promising candidate agents for Parkinson's disease and Alzheimer's disease and network pharmacology analysis DOI Creative Commons

Mingchun Jiang,

Jiaxin Chi,

Yifan Qiao

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107578 - 107578

Published: Jan. 5, 2025

Ginseng has been commonly used as a traditional Chinese medicine in Asian countries for thousands of years. Ginsenosides are the main pharmacologically active ingredients isolated from ginseng and have neuroprotective effects treatment neurodegenerative disorders, such Parkinson's disease (PD) Alzheimer's (AD). To summarise investigate protective roles ginsenosides their underlying mechanisms PD AD, we ''Ginsenoside", ''Parkinson's disease", ''Alzheimer's ''anti-inflammatory", ''antioxidant", ''apoptosis" keywords to search extract relevant literature information scientific databases Elsevier, PubMed, Google Scholar databases. In particular, network pharmacology identify potential targets Rg1 Rb1 AD. By analysing existing research advances results, found that ginsenosides, primarily mediated through anti-inflammation, anti-apoptosis anti-oxidative stress, etc, may be associated with PI3K/Akt, BDNF/TrkB, MAPKs, NF-κB, Nrf2 Wnt/β-catenin signalling pathways. This review systematically summarises different Rg1, Rb1, rare AD provides new strategies disorders. Network paradigm using Rb1.

Language: Английский

Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications DOI Creative Commons
Mengru Liu, Siqi Liu, Zi-Han Lin

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 149 - 149

Published: Jan. 19, 2025

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder marked by the progressive degeneration of midbrain dopaminergic neurons and resultant locomotor dysfunction. Despite over two centuries recognition as chronic disease, exact pathogenesis PD remains elusive. The onset progression involve multiple complex pathological processes, with dysfunctional autophagy elevated oxidative stress serving critical contributors. Notably, emerging research has underscored interplay between in pathogenesis. Given limited efficacy therapies targeting either dysfunction or stress, it crucial to elucidate intricate mechanisms governing their develop more effective therapeutics. This review overviews role nuclear factor erythroid 2-related 2 (Nrf2), pivotal transcriptional regulator orchestrating cellular defense against these processes. By elucidating key processes PD, this will deepen our comprehensive understanding multifaceted underlying may uncover potential strategies for its prevention treatment.

Language: Английский

Citations

3

Gut Microbiota-Based Interventions for Parkinson’s Disease: Neuroprotective Mechanisms and Current Perspective DOI
Deepak Kumar, Mahendra Bishnoi, Kanthi Kiran Kondepudi

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

Citations

2

ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease DOI
Riya Thapa, Ehssan Moglad, Muhammad Afzal

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102327 - 102327

Published: May 10, 2024

Language: Английский

Citations

16

Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration DOI
Riya Thapa, Asif Ahmad Bhat, Moyad Shahwan

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1845, P. 149202 - 149202

Published: Aug. 30, 2024

Language: Английский

Citations

10

Clinical, mechanistic, biomarker, and therapeutic advances in GBA1-associated Parkinson’s disease DOI Creative Commons
Xuxiang Zhang,

Heng Wu,

Beisha Tang

et al.

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 12, 2024

Language: Английский

Citations

9

Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in Caenorhabditis elegans DOI Creative Commons
Julia Tortajada-Pérez, Andrea del Valle Carranza,

Cristina Trujillo-Del Río

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 78 - 78

Published: Jan. 10, 2025

Lipid metabolism plays a critical role in maintaining cellular integrity, especially within the nervous system, where lipids support neuronal structure, function, and synaptic plasticity. However, this essential metabolic pathway is highly susceptible to oxidative stress, which can lead lipid peroxidation, damaging process induced by reactive oxygen species. peroxidation generates by-products that disrupt many functions, with strong impact on proteostasis. In review, we explore of oxidation protein folding its associated pathological implications, particular focus findings neurodegeneration from Caenorhabditis elegans studies, an animal model remains underutilized. Additionally, highlight effectiveness different methodologies applied nematode deepen our understanding intricate process. system any animal, including mammals invertebrates, disturb delicate balance homeostasis, leading build-up toxic by-products, misfolding, key factors neurodegenerative diseases. This disruption contributes pathogenesis disorders such as Alzheimer's, Parkinson's, or Huntington's disease. The studies offer valuable insights into these complex processes potential avenues for developing targeted therapies mitigate disease progression.

Language: Английский

Citations

1

α-Synuclein Iron-Responsive-Element RNA and Iron Regulatory Protein Affinity Is Specifically Reduced by Iron in Parkinson’s Disease DOI Creative Commons
Mateen A. Khan

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 214 - 214

Published: Feb. 2, 2025

α-Synuclein (α-Syn) is implicated in the pathophysiology of Parkinson’s disease (PD) and plays a significant role neuronal degeneration. Iron response proteins (IRPs) bind to iron elements (IREs) found 5′-untranslated regions (5′-UTRs) messenger RNA that encode α-Syn gene. This study used multi-spectroscopic approach techniques investigate impact on IRE binding IRP1. The formation stable complex between IRP1 was suggested by fluorescence quenching results. Fluorescence measurements showed had strong interaction, with constant (Ka) 21.0 × 106 M−1 1:1 stoichiometry. About one site per molecule binding. Ka for RNA•IRP1 added Fe2+ (50 μM) 6.4 μM−1. When added, reduced 3.3 times. These acquired values were further understand thermodynamic characteristics interactions. properties clearly an entropy-favored enthalpy-driven event, negative ΔH small positive ΔS. For RNA•IRP1, Gibbs free energy (ΔG) −43.7 ± 2.7 kJ/mol, but presence Fe2+, it −36.3 2.1 kJ/mol. calculations indicated hydrogen bonding as well van der Waals interactions might help stabilize formation. Additionally, far-UV CD spectra verified formation, induce secondary structural alteration According our findings, alters complexes induces change suggests selectively affects thermodynamics these RNA–protein

Language: Английский

Citations

1

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know? DOI Creative Commons
Carmela Rita Balistreri, Roberto Monastero

Brain Sciences, Journal Year: 2023, Volume and Issue: 14(1), P. 19 - 19

Published: Dec. 23, 2023

The term “neuroinflammation” defines the typical inflammatory response of brain closely related to onset many neurodegenerative diseases (NDs). Neuroinflammation is well known, but its mechanisms and pathways are not entirely comprehended. Some progresses have been achieved through efforts research. Consequently, new cellular molecular mechanisms, diverse conventional, emerging. In listing some those that will be subject our description discussion, essential important roles peripheral infiltrated monocytes clonotypic cells, alterations in gut–brain axis, dysregulation apelinergic system, endothelial glycocalyx component neuronal vascular units, variations expression genes levels encoding molecules by action microRNAs (miRNAs), or other epigenetic factors distinctive transcriptional factors, as role autophagy, ferroptosis, sex differences, modifications circadian cycle. Such can add significantly understanding complex etiological puzzle neuroinflammation ND. addition, they could represent biomarkers targets ND, which increasing elderly.

Language: Английский

Citations

22

Targets to Search for New Pharmacological Treatment in Idiopathic Parkinson’s Disease According to the Single-Neuron Degeneration Model DOI Creative Commons
Sandro Huenchuguala, Juan Segura‐Aguilar

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 673 - 673

Published: June 8, 2024

One of the biggest problems in treatment idiopathic Parkinson’s disease is lack new drugs that slow its progression. L-Dopa remains star drug this disease, although it induces severe side effects. The failure clinical studies with depends on use preclinical models based neurotoxins do not represent what happens since they induce rapid and expansive neurodegeneration. We have recently proposed a single-neuron degeneration model for requires years to accumulate enough lost neurons onset motor symptoms. This excessive formation aminochrome during neuromelanin synthesis surpass neuroprotective action enzymes DT-diaphorase glutathione transferase M2-2, which prevent neurotoxic effects aminochrome. Although an effect, stereotaxic injection endogenous neurotoxin cannot be used generate animal. Therefore, aim review evaluate strategies pharmacologically increasing expression DT diaphorase GSTM2-2 molecules vesicular monoamine transporter 2, such as pramipexole.

Language: Английский

Citations

7

Protective effect of phenylpropionamides in the seed of Cannabis Sativa L. on Parkinson's disease through autophagy DOI

Yi-Kai Jiang,

Mengmeng Li,

Si-Yi Wang

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 175, P. 105883 - 105883

Published: March 6, 2024

Language: Английский

Citations

5