A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

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Low-temperature cold plasma promotes wound healing by inhibiting skin inflammation and improving skin microbiome

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 20, 2025

Wound healing includes four consecutive and overlapping stages of hemostasis, inflammation, proliferation, remodeling. Factors such as aging, infection, chronic diseases can lead to wounds delayed healing. Low-temperature cold plasma (LTCP) is an emerging physical therapy for wound healing, characterized by its safety, environmental friendliness, ease operation. This study utilized a self-developed LTCP device investigate biological effects mechanisms on in adult elderly mice. Histopathological studies found that significantly accelerated the rate skin mice, with particularly pronounced markedly inhibit expression pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) senescence-associated secretory phenotype factors (MMP-3, MMP-9), while increasing tissue repair-related factors, VEGF, bFGF, TGF-β, COL-I, α-SMA. It also regulated genes related cell proliferation migration (Aqp5, Spint1), inflammation response (Nlrp3, Icam1), angiogenesis (Ptx3, Thbs1), promoting apoptosis. Furthermore, treatment reduced relative abundance harmful bacteria Delftia, Stenotrophomonas, Enterococcus, Enterobacter wounds, beneficial Muribaculaceae, Acinetobacter, Lachnospiraceae NK4A136_group, un_f__Lachnospiraceae, thereby improving microbial community structure wounds. These research findings are significant implications understanding mechanism well clinical applications especially aging skin.

Language: Английский

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Characterization of Rugulopteryx okamurae algae: A source of bioactive peptides, omega-3 fatty acids, and volatile compounds

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 143084 - 143084

Published: Jan. 1, 2025

Language: Английский

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Exploring melatonin's signalling pathways in the protection against age-related skin deterioration

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

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The state of the art in anti-aging: plant-based phytochemicals for skin care

Immunity & Ageing, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 31, 2025

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, phenolic compounds work acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, elastase, which degrade structure, reducing levels of inflammatory markers (IL-6, IL-8, etc.) matrix metalloproteinases (MMP-1, MMP-2) linked to aging. Recent research highlights that plant-based phytochemicals can improve elasticity, reduce hyperpigmentation, prevent breakdown important proteins, support wound healing, making them valuable components for care treatments. This review explores multifaceted roles in maintaining improving health, highlighting their mechanisms action potential anti-aging innovations.

Language: Английский

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Human‐Centric, Three Dimensional Micro Light‐Emitting Diodes for Cosmetic and Medical Phototherapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Phototherapy based on micro light‐emitting diodes (µLEDs) has gained enormous attention in the medical field as a patient‐friendly therapeutic method due to its advantages of minimal invasiveness, fewer side effects, and versatile device form factors with high stability biological environment. Effective cosmetic phototherapy depends deep light penetration, precise irradiation, simultaneous multi‐site stimulation, facilitated by three‐dimensional (3D) optoelectronics specifically designed for complex human matters, defined here 3D µLEDs. This perspective article aims present functionalities strategies µLEDs human‐centric phototherapy. study investigates effectiveness enabled three key such shape morphing, self‐adaptation, multilayered spatiotemporal mapping Finally, this provides future insights applications.

Language: Английский

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Gut-Skin Axis: Unraveling the Role of Vitamins in Skin Health

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

The disruption of the skin barrier and immune function has been linked to several conditions, including atopic dermatitis (AD), psoriasis, acne. Both resident non-resident cells, along with skin’s system, play crucial roles in innate immunity. Recent research on microbiota enhanced our understanding interactions between these microorganisms cells. Vitamins, as essential micronutrients, have shown possess antioxidant, anti-inflammatory, antimicrobial properties. immunomodulatory effects vitamins may help prevent progression diseases, making it important explore their immunopharmacology, particularly relation conditions. Additionally, is necessary investigate molecular cellular markers influenced by derivatives. This review focuses key (A, B, C, D, E) taken nutritional supplements, examining findings potential implications for immunity, health, disease.

Language: Английский

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Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care

International Journal of Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

ABSTRACT The concept of aging has evolved from being primarily attributed to genetic factors recognizing the critical role epigenetic mechanisms. Recent advancements, such as clocks, have provided tools assess biological age and offer insights into processes at molecular level. In aesthetic dermatology, understanding these allows for more personalized, effective interventions targeting root causes skin aging. This review explores interplay changes, aging, potential personalized care enhance longevity rejuvenation. is based on an extensive literature search conducted across PubMed other scientific databases. Studies focused mechanisms DNA methylation, histone modifications, their relationship Particular attention was given recent advancements in including Horvath's Clock GrimAge, implications dermatological treatments. Epigenetic Clock, demonstrated utility assessing through methylation markers, revealing actionable processes. Energy‐based devices like fractional lasers radiofrequency shown promise reversing age‐related promoting collagen synthesis, reducing age. Additionally, lifestyle diet, sleep, circadian rhythm alignment significantly influence health. Integrating dermatology represents a paradigm shift rejuvenation, allowing treatments that address visible signs underlying Using clocks provides framework tailoring individual patient needs, optimizing outcomes, extending results. Future research should focus longitudinal studies, accessibility, ethical considerations fully harness epigenetics health overall well‐being.

Language: Английский

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The Role of the Major Histocompatibility Complex Region on Chromosome 6 in Skin Atrophy: A Mendelian Randomization Study

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(3)

Published: March 1, 2025

Skin atrophy (SA) is a pathological condition marked by the thinning of skin, decreased elasticity, and reduced functionality, often arising from aging, chronic glucocorticoid use, or autoimmune diseases. This study investigates role major histocompatibility complex (MHC) region on chromosome 6 in development SA. We applied summary-data-based Mendelian randomization (SMR) using eQTL data three skin-related tissues (whole blood, lower leg, suprapubic) GTEx database, SA genome-wide association FinnGen. Further, we conducted functional enrichment, colocalization, drug enrichment analyses core genes (intersection genes) to explore their functions druggability. Six (PSORS1C3, HLA-C, HLA-DRB5, HLA-DRB6, HLA-DQA1, HLA-DQB1) located 6p21 were consistently identified across all tissues. Functional pathway, protein-protein interaction revealed that these are involved antigen processing immune response regulation. Drug analysis highlighted potential therapeutic targets, including interactions with palladium, azathioprine, insulin. However, limitations available for PSORS1C3 as well inconclusive colocalization results, suggest need further research. highlights involvement six within MHC SA, emphasizing roles regulation presentation. These findings open new avenues understanding offer foundation future investigations into immune-related pathways skin

Language: Английский

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Telomeres in skin aging

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 30, 2025

Language: Английский

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