Valorization of Grape Pomace Extract Through Dextran–Grape Conjugates: A Sustainable Approach for Cosmetic and Dermatological Applications

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(6), P. 3220 - 3220

Published: March 15, 2025

Industrial waste management is a growing concern, and the valorization of by-products through circular economy approaches represents sustainable solution. In this context, dextran–grape conjugates (PLG–GRAPE) were obtained via grafting reaction grape pomace extract dextran under aqueous conditions. To compare properties polymeric graft with those free extract, total polyphenol content was assessed using Folin–Ciocalteu assay, along stability diffusion studies. addition, in vitro safety evaluations, including Neutral Red Uptake, h-CLAT, skin irritation tests performed to assess biocompatibility. evaluate antioxidant, anti-inflammatory, anti-aging PLG–GRAPE, efficacy assays on keratinocyte fibroblast cell lines full-thickness reconstructed human tissues exposed damaging agents, such as UV radiation pollutants. The results showed that technology preserved phenolic antioxidant activity while improving properties. As demonstrated by studies, favorable biocompatibility profile observed, addition significant capacity reduce oxidative stress inflammation aged cells, thus, attenuating cellular aging senescence. conclusion, study suggests PLG–GRAPE has potential bioactive ingredient for cosmetic dermatological applications, offering effective approach utilizing industrial products.

Language: Английский

---

Association and mediation between circulating inflammatory proteins and skin fibrosis

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Skin fibrosis is a dermal lesion associated with inflammatory factors. However, the exact causal relationship between circulating proteins (CIPs) and skin remains unclear. To investigate this potential association mediated effect, Mendelian randomization (MR) two-step MR were used. Summary statistics from genome-wide studies (GWAS) extracted GWAS Catalog for CIPs, blood metabolites (BMs), fibrosis. Two-sample reverse conducted to determine effect of CIPs on Two-step was then performed role BMs in mediating Reverse analysis confirm unidirectional causality BMs, as well Bidirectional revealed negative associations levels T-cell surface glycoprotein CD6 isoform (odds ratio [OR] 0.670 [95% confidence interval [CI] 0.472, 0.951], p = 0.025), Delta Notch-like epidermal growth factor-related receptor (OR 0.779 CI 0.609, 0.998], 0.048), Interleukin-10 subunit beta 0.541 0.332, 0.884], 0.014). There positive Fibroblast factor 21 2.276 1.064, 4.870], 0.034). showed that Retinol (Vitamin A) linoleoyl-arachidonoyl-glycerol (βM 0.108 0.006, 0.210], 0.004) Cholesterol 0.238 0.002, 0.474], 0.048) identified mediators, which evidence Keloid through these mediators. The study presented credible fibrosis, potentially acting mediator association. These findings offer new insights into early screening prevention

Language: Английский

---

Investigating the Impact of GLP-1 Receptor Agonist-Induced Fat Loss on Collagen Synthesis and Skin Elasticity

Journal of Biomedical Science and Engineering, Journal Year: 2025, Volume and Issue: 18(03), P. 45 - 59

Published: Jan. 1, 2025

Language: Английский

---

Collagen type V alpha 3 chain is involved in human skin basement membrane physiology and MMP‐9 regulation

International Journal of Cosmetic Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Collagens are widely studied proteins given their implications in the skin extracellular matrix and pathological conditions such as fibrosis. Type V collagen is a member of fibrillar collagens, three different polypeptide chains, α1, α2 α3 form isoforms through associations. The third chain, α3, type was initially identified placenta, but after decades, it remains poorly characterized. aim this study to investigate expression localization chain its evolution during aging. identification α3(V) target retinoic acid interaction with metalloproteinase-9 (MMP-9) investigated. were assessed by immunodetection ex vivo keratinocytes using calcium-differentiated model. variation aging from donors ages. modulation investigated qPCR immunofluorescence biopsies. Silencing performed siRNA. MMP-9 qPCR. In our study, we showed that abundantly produced basal outer root sheath hair. appears decrease age differentiated keratinocytes. We also treatment biopsies induced expression. Finally, inhibition led an increase This provides better understanding skin. These findings suggest could contribute therapeutic anti-aging value on may open new prospects. data shed more light functional relationship between MMP-9, opening possibilities for eczema treatments.

Language: Английский

---

Retinoid-loaded ionic liquid nanoparticles: Decreased irritation, enhanced transdermal delivery and synergistic anti-wrinkle

Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102735 - 102735

Published: April 19, 2025

Language: Английский

---