Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 9, 2024
Nephrotic syndrome has a significant impact on global health, often leading to cardiovascular disease and high mortality due limited effective treatments. This study investigates the efficacy of Shensu IV in puromycin aminonucleoside (PAN)-induced rat model nephropathy.
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1210 - 1210
Published: Oct. 8, 2024
Posterior capsular opacification (PCO) is the most common long-term complication of cataract surgery. Traditionally, pathogenesis PCO involves residual lens epithelial cells (LECs), which undergo transdifferentiation into a myofibroblast phenotype, hyperproliferation, matrix contraction, and deposition. This process driven by marked upregulation inflammatory growth factors post-surgery. Recently, research on role redox environments has gained considerable attention. LECs, are in direct contact with aqueous humour after surgery, subjected to oxidative stress due decreased levels reduced glutathione increased oxygen content compared outer fibre layer before In this review, we examine critical formation. We also focus glutaredoxins (Grxs), antioxidative enzymes produced via deglutathionylation, their protective against formation, therapeutic potential. Furthermore, discuss latest advancements therapy, particularly development advanced pharmacological agents, emphasise importance approaches anti-inflammatory antioxidant treatments management. conclusion, review highlights significant roles PCO, effects Grxs potential therapies treating PCO.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1454 - 1454
Published: Nov. 27, 2024
Hypertension (HTN) is a major contributor to kidney damage, leading conditions such as nephrosclerosis and hypertensive nephropathy, significant causes of chronic disease (CKD) end-stage renal (ESRD). HTN also risk factor for stroke coronary heart disease. Oxidative stress, inflammation, activation the renin–angiotensin–aldosterone system (RAAS) play critical roles in causing injury HTN. Genetic environmental factors influence susceptibility with African American populations having higher tendency due genetic variants. Managing blood pressure (BP) effectively treatments targeting RAAS activation, oxidative inflammation crucial preventing damage progression HTN-related CKD ESRD. Interactions between impacting function abnormalities are central development. Animal studies indicate that significantly BP regulation. Anti-natriuretic mechanisms can reset pressure–natriuresis relationship, requiring excrete sodium matched intake. Activation intrarenal angiotensin II receptors contributes retention high BP. In HTN, gut microbiome affect by influencing energy metabolism inflammatory pathways. models, spontaneously rat infusion model, mirror human essential hypertension highlight significance pathogenesis. Overproduction reactive oxygen species (ROS) plays role development Targeting specific NADPH oxidase (NOX) isoforms inhibit ROS production enhance antioxidant may improve structure while lowering pressure. Therapies like SGLT2 inhibitors mineralocorticoid receptor antagonists have shown promise reducing activity, offering antihypertensive protection managing CKD. This review emphasizes NOX focusing on its impact Effective management
Language: Английский
Citations
1
IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: March 13, 2024
Chronic kidney disease (CKD) affects 10% of humans and increases the risk cardiovascular diseases. Regardless etiology, tubulointerstitial fibrosis (TIF) is histopathological feature CKD that correlates with loss renal function, excessive growth factor (GF) activation a common mechanism in CKD. Among several GF pathways, TGF-β/β-catenin axis plays crucial role pathophysiology Most compelling studies reported pivotal proximal tubule (PT), most metabolic vulnerable segment, post-injury response pathogenesis Though systemic detrimental CKD, recent have beneficial effects PT’s to chronic injury. This chapter describes findings on Using genetically modified mice biochemical microscopy techniques, revealed promoting mitochondrial homeostasis, regenerative Th1 immune response, G1 cell arrest, survival. Future experimental should identify key downstream effectors this can be targeted mitigate progression.
Language: Английский
Citations
0
Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown
Published: July 16, 2024
Understanding the genetic basis of local adaptation and distribution standing variation is imperative for biodiversity conservation as species decline globally. The Atlantic song sparrow (Melospiza melodia atlantica) a specialist subspecies concern that adapted to coastal habitats eastern North America interbreeds with widespread, parapatric generalist subspecies, (M. m. melodia). Because sparrows offer an ideal opportunity explore evolutionary dynamics gene flow, we examined genomic architecture divergence using whole-genome sequencing these subspecies. We identified polygenic adaptation, candidate genes related osmoregulation, plumage pigmentation, bill size. Divergent were dispersed throughout homogenous background, demonstrating strong natural selection key force maintaining differentiation between despite flow. Notably, some located near centromeres telomeres, suggesting regions suppressed recombination may play role in maintenance flow this system. found population structure within sparrow, southern barrier islands making up portion range each island comprising distinct cluster, which inform future management decisions. This system emphasizes need high-resolution data characterize adaptive effective strategies systems extensive
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 9, 2024
Nephrotic syndrome has a significant impact on global health, often leading to cardiovascular disease and high mortality due limited effective treatments. This study investigates the efficacy of Shensu IV in puromycin aminonucleoside (PAN)-induced rat model nephropathy.
Language: Английский
Citations
0