Physicochemical properties and health benefits of resistant starch, resistant dextrin, and Polydextrose: Similarities and differences

Grain & Oil Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Multi-omics reveals the alleviating effect of berberine on ulcerative colitis through modulating the gut microbiome and bile acid metabolism in the gut-liver axis

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

The dysfunction of gut microbiome and bile acid metabolism might cause the incidence relapse ulcerative colitis (UC). Thus, natural products have been considered effective for UC through regulation acid. In this study, we evaluated regulatory effect berberine on in UC. Results showed that relative abundances beneficial bacteria a decreasing trend model, taurine conjugated acids increased from liver tissue to colon tissue. Berberine inhibited colonization harmful promoted primary metabolism. Moreover, used multi-omics technology (metagenomics, metabolomics, transcriptomics technology) reveal restored intestinal barrier function acid/S1PR2/RhoA/ROCK pathway. result transmission electron microscopy directly damaged mucosal was repaired treatment. This study revealed treatment influence

Language: Английский

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In-Depth Investigation of the Mechanisms Underlying Recrystallized Resistant Starch-Induced Amelioration of Insulin Resistance in T2DM Mice via Liver Metabolomics Integrated with Colon Transcriptomics

ACS Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

The effects of A-type recrystallized resistant starch (ARS) on ameliorating insulin resistance in type 2 diabetes mellitus (T2DM) mice were investigated using liver metabolomics integrated with colon transcriptomics. Mice supplied medium and high ARS doses exhibited lower fasting serum HOMA-IR, reduced resistance, elevated HOMA-IS HOMA-β levels, indicating that can improve sensitivity. significantly triglyceride nonesterified fatty acid fat accumulation, hepatic interleukin-1β interleukin-6 levels T2DM mice. Liver metabolomic analysis revealed modulated the cysteine-methionine glycerophospholipid metabolic pathways. Moreover, may enhance inhibition PI3K/Akt, NF-κB, AMPK, II mellitus, pathways by regulating expression Tnf-α, Socs1, Irs3, Lipe, thereby Thus, our findings support potential preventive therapeutic treatment.

Language: Английский

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Grain actives modulate gut microbiota to improve obesity-related metabolic diseases: A review

Food Research International, Journal Year: 2024, Volume and Issue: 199, P. 115367 - 115367

Published: Nov. 19, 2024

Language: Английский

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