Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 30, 2024
Accumulating
evidence
indicates
that
cellular
senescence
is
closely
associated
with
osteoarthritis.
However,
there
limited
research
on
the
mechanisms
underlying
fibroblast-like
synoviocyte
and
its
impact
osteoarthritis
progression.
Here,
we
elucidate
a
positive
correlation
between
progression
reveal
GATD3A
deficiency
induces
senescence.
Mechanistically,
enhances
binding
of
Sirt3
to
MDH2,
leading
deacetylation
decreased
activity
MDH2.
Reduced
MDH2
impairs
tricarboxylic
acid
cycle
flux,
resulting
in
mitochondrial
dysfunction
Intra-articular
injection
recombinant
adeno-associated
virus
carrying
significantly
alleviates
phenotype
male
mice.
This
study
increases
our
current
understanding
function.
In
particular,
novel
mechanism
senescence,
suggesting
targeting
potential
therapeutic
approach
for
The
are
unclear.
authors
show
mice
demonstrate
symptoms
mouse
models
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 217 - 235
Published: June 30, 2024
Obesity
is
a
chronic
disease,
both
alone
and
accompanied
by
many
metabolic
diseases
it
causes,
that
require
prevention
treatment
to
normalize
living
standards
in
terms
of
women's
health.
For
this
reason,
professional
support
needed
for
older
individuals
who
are
overweight
or
candidates
obesity,
as
well
with
advanced
obesity.
Looking
at
the
problem
obesity
elderly
from
perspective,
awareness
should
be
increased
regular
physical
activity
can
optimize
chances
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 4, 2024
Identifying
biomarkers
able
to
discriminate
individuals
on
different
health
trajectories
is
crucial
understand
the
molecular
basis
of
age-related
morbidity.
We
investigated
multi-omics
signatures
general
and
organ-specific
morbidity,
as
well
their
interconnectivity.
examined
cross-sectional
metabolome
proteome
data
from
3,142
adults
Cooperative
Health
Research
in
South
Tyrol
(CHRIS)
study,
an
Alpine
population
study
designed
investigate
how
human
biology,
environment,
lifestyle
factors
contribute
people's
over
time.
had
174
metabolites
148
proteins
quantified
fasting
serum
plasma
samples.
used
Cumulative
Illness
Rating
Scale
(CIRS)
Comorbidity
Index
(CMI),
which
considers
morbidity
14
organ
systems,
assess
status
(any
vs.
healthy).
Omics-signatures
for
were
identified
using
random
forest
(RF)
classifiers.
Linear
regression
models
fitted
directionality
omics
markers
associations,
identify
related
Next
age,
we
21
10
relevant
predictors
results
confirmed
associations
serotonin
glutamate
be
age-independent.
Considering
several
jointly
endocrine,
cardiovascular,
renal
To
conclude,
circulating
was
a
potential
novel
predictor
overall
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 30, 2024
Accumulating
evidence
indicates
that
cellular
senescence
is
closely
associated
with
osteoarthritis.
However,
there
limited
research
on
the
mechanisms
underlying
fibroblast-like
synoviocyte
and
its
impact
osteoarthritis
progression.
Here,
we
elucidate
a
positive
correlation
between
progression
reveal
GATD3A
deficiency
induces
senescence.
Mechanistically,
enhances
binding
of
Sirt3
to
MDH2,
leading
deacetylation
decreased
activity
MDH2.
Reduced
MDH2
impairs
tricarboxylic
acid
cycle
flux,
resulting
in
mitochondrial
dysfunction
Intra-articular
injection
recombinant
adeno-associated
virus
carrying
significantly
alleviates
phenotype
male
mice.
This
study
increases
our
current
understanding
function.
In
particular,
novel
mechanism
senescence,
suggesting
targeting
potential
therapeutic
approach
for
The
are
unclear.
authors
show
mice
demonstrate
symptoms
mouse
models
