Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma DOI Creative Commons
Yihong Li, Xuejie Yang, Zhen Wei

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 17(1), P. 34 - 34

Published: Dec. 30, 2024

Background/Objectives: The two obstacles for treating glioma are the skull and blood brain–barrier (BBB), first of which forms a physical shield that increases difficulties traditional surgery or radiotherapy, while latter prevents antitumor drugs reaching tumor sites. To conquer these issues, we take advantage high penetrating ability sonodynamic therapy (SDT), combined with novel nanocomplex can easily pass BBB. Methods: Through ultrasonic polymerization, amphiphilic peptides (C18GR7RGDS) were self-assembled as spherical shell encapsulating sonosensitizer Rose Bengal (RB) plant-derived compound, sulforaphane (SFN), to form SFN@RB@SPM. Results/Conclusions: SFN@RB@SPM be internalized by cells through tumor-targeting motif RGDS (abbreviated peptide sequence composed arginine, glycine, aspartic acid, serine), further executes function during SDT. Also, could taken up U87-MG cross BBB in glioma-bearing mice mechanism investigation revealed that, compared SFN-free (RB@SPM), induced much more apoptosis an ROS-dependent manner depletion glutathione SFN cavitation effect In animal experiments, besides significant reduction volume delay losing body weight, H&E staining showed massive infiltration neutrophils adjacent sites, indicating this synergistically augment SDT efficacy, partially enhancing innate immunity.

Language: Английский

Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites DOI Creative Commons
Yun Teng, Chao Luo,

Xiaolan Qiu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 3, 2025

Abstract Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. Here we investigate plant-derived nanoparticles (PNP) on and metabolites in context cancer immunotherapy with humanized gnotobiotic mouse model. Specifically, show that ginger-derived exosome-like nanoparticle (GELN) preferentially taken up by Lachnospiraceae Lactobacillaceae mediated digalactosyldiacylglycerol (DGDG) glycine, respectively. We further demonstrate GELN aly-miR159a-3p enhances anti-PD-L1 therapy melanoma inhibiting expression recipient bacterial phospholipase C (PLC) increases accumulation docosahexaenoic acid (DHA). An increased level circulating DHA inhibits PD-L1 tumor cells binding promoter subsequently prevents c-myc-initiated transcription PD-L1. Colonization germ-free male mice bacteria from non-responding patients supplemented efficacy compared controls. Our findings reveal previously unknown mechanistic PNP human modulating metabolic pathways.

Language: Английский

Citations

4
Gut microbiota in Alzheimer’s disease: Understanding molecular pathways and potential therapeutic perspectives DOI

Simone Lista,

Antonio Munafò, Filippo Caraci

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102659 - 102659

Published: Jan. 10, 2025

Language: Английский

Citations

2
Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management DOI Creative Commons
Adil Hassan, Yin Huang,

Mahjabina

et al.

iMetaOmics., Journal Year: 2024, Volume and Issue: 1(2)

Published: Oct. 25, 2024

Abstract Targeting gut flora to lower sickness risk is a growing scientific subject. The intricate network of microorganisms (gut microbiota) in the human intestines regulates many physiological systems and may be important for general health. Recent research has shown dynamic relationship between microbiota central nervous system (CNS). Dysbiosis key establishing progressing diseases, including neurodegenerative disorders. Recently, extracellular vesicles (GMEVs) have been suggested as brain‐gut communication carriers. Vesicle components contact immune receptors, initiating neuroinflammatory responses causing diseases. This study seeks explain how its cause or worsen We also highlighted recent advances our understanding these GMEVs' cargo's routes, which could used drug delivery treatments. examines current state potential therapeutic effects GMEVs on illnesses.

Language: Английский

Citations

0
Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma DOI Creative Commons
Yihong Li, Xuejie Yang, Zhen Wei

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 17(1), P. 34 - 34

Published: Dec. 30, 2024

Background/Objectives: The two obstacles for treating glioma are the skull and blood brain–barrier (BBB), first of which forms a physical shield that increases difficulties traditional surgery or radiotherapy, while latter prevents antitumor drugs reaching tumor sites. To conquer these issues, we take advantage high penetrating ability sonodynamic therapy (SDT), combined with novel nanocomplex can easily pass BBB. Methods: Through ultrasonic polymerization, amphiphilic peptides (C18GR7RGDS) were self-assembled as spherical shell encapsulating sonosensitizer Rose Bengal (RB) plant-derived compound, sulforaphane (SFN), to form SFN@RB@SPM. Results/Conclusions: SFN@RB@SPM be internalized by cells through tumor-targeting motif RGDS (abbreviated peptide sequence composed arginine, glycine, aspartic acid, serine), further executes function during SDT. Also, could taken up U87-MG cross BBB in glioma-bearing mice mechanism investigation revealed that, compared SFN-free (RB@SPM), induced much more apoptosis an ROS-dependent manner depletion glutathione SFN cavitation effect In animal experiments, besides significant reduction volume delay losing body weight, H&E staining showed massive infiltration neutrophils adjacent sites, indicating this synergistically augment SDT efficacy, partially enhancing innate immunity.

Language: Английский

Citations

0