Enzymes in the Content of Combined Antimicrobials as Improvers of Their Action DOI Creative Commons
Nikolay Stepanov, Aysel Aslanli, Maksim Domnin

et al.

Journal of NBC Protection Corps, Journal Year: 2024, Volume and Issue: 8(2), P. 146 - 163

Published: Sept. 4, 2024

Accumulating information about the growing number of microorganisms that are resistant to antibiotics used, on one hand, and emergence presence laboratories in which closed work is carried out with microbial pathogens, negative properties can be artificially enhanced. The aim analyze current trends development antimicrobial drugs combining use wellknown widely used antibiotics, as well substances properties, including metal nanoparticles, peptides, various enzymes allow preserve enhance effect against cells source base research mainly English–language scientific literature available via global Internet network, authors’ own published experimental studies. method analytical. Results. considers that, unlike classical agents, more often enter into reactions inhibiting key biochemical reactions, catalysts for processes aimed at oxidation hydrolysis molecules metabolically structurally important microorganisms. Conclusion. enzyme repeatedly enters significantly reduce concentrations vital activity cells, leads their weakening effective action agents. Most often, this case, themselves act carriers action, avoids non-specific interaction other, primarily proteins, thus removing some, example, from active pathogen cells. It has been demonstrated enzymatic enhancement bactericidal agents relation different complex biosystems (biofilms) formed by them, both several times orders magnitude. Such combined may interest carrying sanitary treatments surfaces, containers, premises, biological laboratories, introduction protective dressing materials.

Language: Английский

“Stop, Little Pot” as the Motto of Suppressive Management of Various Microbial Consortia DOI Creative Commons
Елена Ефременко, Nikolay Stepanov,

Olga Senko

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1650 - 1650

Published: Aug. 12, 2024

The unresolved challenges in the development of highly efficient, stable and controlled synthetic microbial consortia, as well use natural are very attractive for science technology. However, consortia management should be done with knowledge how not only to accelerate but also stop action such "little pots". Moreover, there a lot activity which suppressively controlled. processes, catalyzed by various microorganisms being complex slowed down or completely cancelled, typical environment (biocorrosion, landfill gas accumulation, biodegradation building materials, water sources deterioration etc.), industry (food biotechnological production), medical practice (vaginitis, cystitis, intestinal dysbiosis, etc.). search ways suppress functioning heterogeneous each these areas is relevant. purpose this review summarize general trends studies regarding targets new means influence used. analysis features applied approaches solving main problem confirms possibility obtaining combined effect, selective on individual components consortia. Of particular interest role viruses suppressing different compositions.

Language: Английский

Citations

1
Action enhancement of antimicrobial peptides by their combination with enzymes hydrolyzing fungal quorum molecules DOI
Aysel Aslanli, Maksim Domnin, Nikolay Stepanov

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136066 - 136066

Published: Sept. 1, 2024

Language: Английский

Citations

1
Enzymes in the Content of Combined Antimicrobials as Improvers of Their Action DOI Creative Commons
Nikolay Stepanov, Aysel Aslanli, Maksim Domnin

et al.

Journal of NBC Protection Corps, Journal Year: 2024, Volume and Issue: 8(2), P. 146 - 163

Published: Sept. 4, 2024

Accumulating information about the growing number of microorganisms that are resistant to antibiotics used, on one hand, and emergence presence laboratories in which closed work is carried out with microbial pathogens, negative properties can be artificially enhanced. The aim analyze current trends development antimicrobial drugs combining use wellknown widely used antibiotics, as well substances properties, including metal nanoparticles, peptides, various enzymes allow preserve enhance effect against cells source base research mainly English–language scientific literature available via global Internet network, authors’ own published experimental studies. method analytical. Results. considers that, unlike classical agents, more often enter into reactions inhibiting key biochemical reactions, catalysts for processes aimed at oxidation hydrolysis molecules metabolically structurally important microorganisms. Conclusion. enzyme repeatedly enters significantly reduce concentrations vital activity cells, leads their weakening effective action agents. Most often, this case, themselves act carriers action, avoids non-specific interaction other, primarily proteins, thus removing some, example, from active pathogen cells. It has been demonstrated enzymatic enhancement bactericidal agents relation different complex biosystems (biofilms) formed by them, both several times orders magnitude. Such combined may interest carrying sanitary treatments surfaces, containers, premises, biological laboratories, introduction protective dressing materials.

Language: Английский

Citations

0