Establishment of an efficacy-oriented quality grading framework for herbal medicines: Phyllanthus emblica as an example

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119632 - 119632

Published: March 1, 2025

Language: Английский

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Association of Low BMI, Elevated Model for End-Stage Liver Disease Score, and Poor Functional Status With Increased 30-Day Readmission After Orthotopic Liver Transplant: A Retrospective Cohort Study

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Background Liver transplantation is the ultimate treatment for end-stage liver disease. However, post-transplant management very complex, with need meticulous immunosuppression regimens and multidisciplinary coordinated specialist care. This can be complicated by a higher risk of readmissions after transplant. Readmission rates are now being used as measure facility's efficacy post-transplant. In this study, we investigated recipient characteristics that may place recipients at 30-day readmission. Method Chi-square independent t-test analyses six variables were performed accordingly on transplant data extracted from Standard Transplant Analysis Research (STAR) data. The Model End-Stage Disease (MELD) score, body mass index (BMI), age, diabetes status, hepatitis C functional status. association between these readmission was investigated. Results We observed factors, including elevated MELD positive mellitus lower which increase hospitalization Of examined characteristics, BMI, status significantly associated t values P follows: t(38,180) = 4.080, 4.514E-05 BMI; score; 2.729, 6.356E-03 Conclusion Our study shows average identified high-risk within 30 days These findings might help centers anticipate complication possibly implement better nutritional optimization prior to closer follow-up Further research could identify specific thresholds worse outcomes.

Language: Английский

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The impact of age and frailty on hospitalization and survival in older liver transplant recipients: a longitudinal cohort study

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: April 28, 2025

Frailty is a well-established risk factor for adverse outcomes, particularly in liver transplant candidates. This study investigates the impact of age and frailty on key clinical outcomes-hospitalizations, waitlist survival, post-transplant mortality-in cirrhotic patients evaluated transplantation. included older adults with chronic disease under consideration Data collected encompassed medical history, Model End-Stage Liver Disease (MELD) Child-Turcotte-Pugh (CTP) scores, Mini-Mental State Examination (MMSE), Mini Nutritional Assessment (MNA), status, assessed using both Index (LFI) Survey Health, Ageing, Retirement Europe (SHARE-FI). Clinical including mortality hospitalizations, were tracked over 24-month period. Among 100 (67% male), those 70 exhibited higher MNA, MMSE, SHARE-FI scores. Based classification, 25 frail, 28 pre-frail, 47 robust. Younger experienced more hospitalizations during follow-up (p = 0.03) had probability hospitalization within 24 months 0.002). Although transplant-free survival did not differ significantly across groups, frail rate 0.04). Overall, underwent transplantation, while 26 died, six deaths. MELD CTP scores strong predictors mortality, among measures, only demonstrated significant predictive value. In multivariate Cox models, [HR 1.17, p 0.001; HR 1.11, 0.002], 1.43, 0.003; 1.41, 0.006], LFI (HR 1.69, 0.04) associated mortality. Frailty, rather than age, emerges as predictor Further research needed to validate these findings enhance assessment, ultimately improving candidate selection

Language: Английский

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Understanding the Role of Alcohol in Metabolic Dysfunction and Male Infertility

Metabolites, Journal Year: 2024, Volume and Issue: 14(11), P. 626 - 626

Published: Nov. 15, 2024

Over the past 40-50 years, demographic shifts and obesity epidemic have coincided with significant changes in lifestyle habits, including a rise excessive alcohol consumption. This increase intake is major public health concern due to its far-reaching effects on human health, particularly metabolic processes male reproductive function. narrative review focuses role of consumption altering metabolism impairing testicular function, emphasizing potential damage associated both acute chronic intake.

Language: Английский

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Gestão da Insuficiência Hepática Aguda em Pacientes com Hepatite Viral Crônica

Brazilian Journal of Implantology and Health Sciences, Journal Year: 2024, Volume and Issue: 6(8), P. 2589 - 2605

Published: Aug. 18, 2024

Este artigo revisa a gestão da insuficiência hepática aguda (IHA) em pacientes com hepatite viral crônica, uma condição grave que resulta alta mortalidade e requer intervenções rápidas eficazes. A especialmente as causadas pelos vírus B (HBV) C (HCV), pode evoluir para IHA devido reativações virais, superinfecções ou fatores como ingestão de álcool uso medicamentos hepatotóxicos. O objetivo deste estudo foi revisar literatura existente identificar estratégias eficazes prevenção manejo clínico crônica. metodologia envolveu revisão integrativa artigos publicados entre 2013 2023, utilizando bases dados PubMed, SciELO, LILACS, critérios inclusão rigorosos garantir relevância dos estudos analisados. Os resultados indicam nesses é frequentemente precipitada por combinação fatores, incluindo virais exposição agentes eficaz supressão replicação através do antivirais, suporte intensivo unidades terapia intensiva, e, casos graves, o transplante hepático emergencial. mostrou-se intervenção mais estado crítico, proporcionando taxas sobrevivência significativamente maiores longo prazo. No entanto, continua sendo foco eficaz, ênfase no monitoramento regular função hepática, adesão estrita à antiviral, educação sobre os riscos substâncias hepatotóxicas. Conclui-se que, embora seja crucial salvar vidas avançados, preventivas precoces são essenciais reduzir incidência melhorar clínicos

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Electrical and Viscoelastic Parameters of Erythrocytes as a Part of Diagnostic Models for Differentiating Fatty Liver Disease of Mixed Genesis from Non-Alcoholic and Alcohol-Related Fatty Liver Disease

Russian Journal of Gastroenterology Hepatology Coloproctology, Journal Year: 2024, Volume and Issue: 34(3), P. 38 - 52

Published: Aug. 21, 2024

Aim: creation of diagnostic models including electrical, viscoelastic parameters erythrocytes to distinguish fatty liver disease mixed etiology (metabolic + alcoholic) from non-alcoholic and alcoholic disease. Materials methods. We examined 46 men with (NAFLD), 43 (AFLD), as well 54 (FLD) genesis alcohol-related); average age the patients included in study made 48.4 ± 9.6 years. The diagnosis was established on basis ultrasound findings FLI steatosis index a fibrosis grade F1 or less (FibroScan ® 502, Echosens, France). electrical were investigated by technique dielectrophoresis using an electrooptical cell detection system. Results. most significant for differentiating NAFLD Volcano plot have turned out be polarizability at frequency 10 6 Hz ( p = 6.49 ×10 -5 ), erythrocyte membrane capacity 0.00077), relative 0.001), levels which higher NAFLD. On contrary, red blood cells destruction 5 FLD 0.047) crossover shifted high range more than 0.0005). discriminant analysis has additionally revealed significance degree deformation distinguishing between mixed-genesis In NAFLD, model incorporating above provided AUC 0.829 (confidential interval: 0.742–0.916), sensitivity 80.9 %, specificity 83.3 %. Two indicators been that statistically significantly AFLD (Volcano plot); these are Hz, 0.0007), membranes, value prevailed 0.011). When AFLD, combined inclusion three cells, namely shown highest accuracy, 0.751 0.611–0.908) 79.5 74.7 Conclusion. studied should considered promising biomarkers diffuse

Language: Английский

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Gegen-Sangshen oral liquid and its active fractions mitigate alcoholic liver disease in mice through repairing intestinal epithelial injury and regulating gut microbiota

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 23, 2024

Abstract Background Liuweizhiji Gegen-Sangshen oral liquid (LGS), as a Chinese medicinal preparation, is developed from Traditional formula consisting of six herbs, including Puerariae lobatae radix, Hoveniae semen, Imperatae rhizoma, Crataegi fructus, Mori fructus and Canarli has been extensively utilized in the prevention treatment alcoholic liver disease (ALD) clinically. Previous study demonstrated that LGS dose-dependently mitigated ALD rat models. However, whether how main characteristic constituents (the flavonoid polysaccharide fractions, LGSF LGSP) contribute to anti-ALD effect remains unclear. This aimed assess its fractions (LGSF murine model explore underlying mechanisms. Methods mouse was constructed using chronic binge ethanol feeding method. Biochemical determinations AST, ALT, TC, TG, ADH, ALDH, HDL, LDL, IL-1β, IL-6, TNF-α were performed corresponding kits. Histopathological examination intestinal sections conducted based on H&E staining. Lipid accumulation hepatocytes evaluated by oil red O Ethanol metabolism assessed determining activity ADH ALDH enzymes. Intestinal barrier function analyzed immunohistochemistry analysis ZO-1 occludin immunofluorescence epithelial markers, Lgr5, Muc2, Lyz1. apoptosis detected TUNEL Mouse fecal microbiota alterations 16S rRNA sequencing. An vitro injury established developing TNF-α-induced 3D-cultured organoids. In culture specific bacterial strains performed. Results The results showed significantly alleviated mice through attenuating hepatic inflammation, improving steatosis promoting metabolism. Notably, LGS, LGSP, damage maintained mice. protection generally more obvious than positive drug meltadosine. Further promoted repair via Lgr5 + stem cell mediated regeneration LGSF, other had better vitro. Moreover, remarkably gut dysbiosis at least partially recovery alcohol-induced microbial changes induction groups. indicated impact growth. but not growth Lactobacillus . Similarly, LGSP increased proliferation Bacteroides sartorii , minimal effect. all Bacillus coagulans Bifidobacterium adolescentis bifidum Dubosiella newyorkensis no Conclusions exerts regulating gut-liver axis, are responsible for protective

Language: Английский

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