Pulmonary hypertension post-liver transplant: A case report DOI
Sami Alharbi, Noura Alturaif, Yehya A. Mostafa

et al.

World Journal of Gastrointestinal Surgery, Journal Year: 2024, Volume and Issue: 16(12), P. 3875 - 3880

Published: Nov. 27, 2024

BACKGROUND Liver transplantation (LTx) is vital in patients with end-stage liver disease, metabolic dysfunction-associated steatotic disease being the most common indication. Primary sclerosing cholangitis (PSC) an important Portopulmonary hypertension, associated portal poses a significant perioperative risk, making pretransplant screening essential. CASE SUMMARY We report case of 41-year-old woman PSC who developed severe pulmonary hypertension years after successful LTx. She presented worsening dyspnea on exertion and presyncope. Diagnostic evaluation confirmed precapillary without evidence recurrent hypertension. Initial management Sildenafil Macitentan led to improvement her symptoms, exercise capacity, biomarkers. This highlights rare development de novo transplant recipient possibly linked autoimmune processes or primary itself. The patient’s positive response combination therapy underscores importance prompt diagnosis aggressive management. CONCLUSION In conclusion, arterial post-LTx but serious complication poor prognosis, necessitating further research better understand its mechanisms develop effective strategies for prevention treatment.

Language: Английский

Advances and applications of biosensors in pulmonary hypertension DOI Creative Commons
Zhi Liu,

Zhenghai Bai,

Xiang Chen

et al.

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 15, 2025

Pulmonary hypertension (PH) is a serious disease characterized by elevated pulmonary artery pressure, with its prevalence and incidence continuously increasing, posing threat to the lives of many patients worldwide. Due complex etiology PH lack specificity in clinical manifestations, there currently effective specific methods for early diagnosis practice. Biosensors hold significant promise detection, therapeutic monitoring, prognostic evaluation, personalized treatment PH, owing their rapid, sensitive, highly selective characteristics. The rapid development various types biosensors, such as electrochemical optical microfluidic wireless combined use nanomaterials, makes accurate detection PH-related biomarkers possible. Despite broad application prospects biosensors field challenges remain terms sensitivity, selectivity, stability, regulation. This article reviews main pathophysiological mechanisms commonly used principles summarizes progress research well current challenges, order promote further in-depth biosensor technology, thereby improving effects PH. Clinical trial number: Not applicable.

Language: Английский

Citations

0
Facilities in Molecular Biomarkers in Cardiology DOI Creative Commons
Pietro Scicchitano, Matteo Cameli

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 1025 - 1025

Published: Aug. 17, 2024

This Special Issue of

Language: Английский

Citations

0
Identification of metabolic biomarkers in idiopathic pulmonary arterial hypertension using targeted metabolomics and bioinformatics analysis DOI Creative Commons
Chuang Yang, Yihang Liu,

Haikuo Zheng

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 25, 2024

Pulmonary arterial hypertension (PAH) is a life-threatening disease with poor prognosis, and metabolic abnormalities play critical role in its development. This study used metabolomics, machine learning algorithms bioinformatics to screen for potential biomarkers associated the diagnosis of PAH. In this study, plasma samples were collected from 17 patients diagnosed idiopathic pulmonary (IPAH) 20 healthy controls. Plasma metabolomic profiling was performed by high-performance liquid chromatography-mass spectrometry. Gene profiles PAH obtained GEO database. Key differentially expressed metabolites (DEMs) metabolism-related genes subsequently identified using algorithms. Twenty differential IPAH (VIP score > 1 p < 0 0.05), enrichment analysis revealed arginine biosynthesis pathway as most altered pathway. Using models, including least absolute shrinkage selection operator (LASSO), random forest (RF) support vector (SVM), we extracted key that correlated clinical phenotypes. Our results suggested five metabolites, kynurenine, homoserine, tryptophan, AMP, spermine, are IPAH. Bioinformatics also 3 genes, MAPK6, SLC7A11 CDC42BPA, strongly hypertension, demonstrating strong predictive power relevance. findings some metabolism PH, provided crucial information about complex reprogramming signals may lead identification useful

Language: Английский

Citations

0
Pulmonary hypertension post-liver transplant: A case report DOI
Sami Alharbi, Noura Alturaif, Yehya A. Mostafa

et al.

World Journal of Gastrointestinal Surgery, Journal Year: 2024, Volume and Issue: 16(12), P. 3875 - 3880

Published: Nov. 27, 2024

BACKGROUND Liver transplantation (LTx) is vital in patients with end-stage liver disease, metabolic dysfunction-associated steatotic disease being the most common indication. Primary sclerosing cholangitis (PSC) an important Portopulmonary hypertension, associated portal poses a significant perioperative risk, making pretransplant screening essential. CASE SUMMARY We report case of 41-year-old woman PSC who developed severe pulmonary hypertension years after successful LTx. She presented worsening dyspnea on exertion and presyncope. Diagnostic evaluation confirmed precapillary without evidence recurrent hypertension. Initial management Sildenafil Macitentan led to improvement her symptoms, exercise capacity, biomarkers. This highlights rare development de novo transplant recipient possibly linked autoimmune processes or primary itself. The patient’s positive response combination therapy underscores importance prompt diagnosis aggressive management. CONCLUSION In conclusion, arterial post-LTx but serious complication poor prognosis, necessitating further research better understand its mechanisms develop effective strategies for prevention treatment.

Language: Английский

Citations

0