Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment DOI Creative Commons
Wenqiang Li, Quan Yuan, Mei Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 31, 2024

Lung cancer (LC) is one of the most common worldwide. Tumor-associated macrophages (TAMs) are important component tumor microenvironment (TME) and closely related to stages occurrence, development, metastasis. Macrophages plastic can differentiate into different phenotypes functions under influence signaling pathways in TME. The classically activated (M1-like) alternatively (M2-like) represent two polarization states macrophages. M1 exhibit anti-tumor functions, while M2 considered support cell survival Macrophage involves complex pathways, blocking or regulating these enhance macrophages' effects has become a research hotspot recent years. At same time, there have been new discoveries regarding modulation TAMs towards an phenotype by synthetic natural drug components. Nanotechnology better achieve combination therapy targeted delivery drugs, maximizing efficacy drugs minimizing side effects. Up now, nanomedicines targeting various active substances for reprogramming made significant progress. In this review, we primarily provided comprehensive overview crosstalk between cells LC microenvironment. Additionally, latest advancements novel nano-based systems (NDDSs) that target were also reviewed. Finally, discussed prospects as therapeutic targets barriers clinical translation.

Language: Английский

Dynamic Multilevel Regulation of EGFR, KRAS, and MYC Oncogenes: Driving Cancer Cell Proliferation Through (Epi)Genetic and Post-Transcriptional/Translational Pathways DOI Open Access
Mário Šereš,

Katarina Spacayova,

Zdena Sulová

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 248 - 248

Published: Jan. 14, 2025

The epidermal growth factor receptor (EGFR) regulates gene expression through two primary mechanisms: as a in the nucleus, where it translocates upon binding its ligand, or via intrinsic tyrosine kinase activity cytosol, modulates key signaling pathways such RAS/MYC, PI3K, PLCγ, and STAT3. During tumorigenesis, these become deregulated, leading to uncontrolled proliferation, enhanced migratory metastatic capabilities, evasion of programmed cell death, resistance chemotherapy radiotherapy. RAS MYC oncogenes are pivotal driving processes apoptosis, replicative immortality, cellular invasion metastasis, metabolic reprogramming. These subject regulation by range epigenetic post-transcriptional modifications. This review focuses on deregulation EGFR, RAS, caused (epi)genetic alterations post-translational It also explores therapeutic potential targeting regulatory proteins, emphasizing importance phenotyping neoplastic tissues inform treatment cancer.

Language: Английский

Citations

2
Fingerprint of ubiquitin coupled enzyme UBC13 in health and disease DOI

Ru-Yi Chen,

Yanjun Liu, Ran Wang

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108524 - 108524

Published: April 1, 2025

Language: Английский

Citations

0
Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review DOI Creative Commons

Chang Gao,

Yanjun Liu, Jing Yu

et al.

Cells, Journal Year: 2024, Volume and Issue: 14(1), P. 15 - 15

Published: Dec. 26, 2024

Ubiquitin-conjugating enzyme E2 T (UBE2T) is a crucial in the ubiquitin-proteasome system (UPS), playing significant role ubiquitination of proteins and influencing wide range cellular processes, including proliferation, differentiation, apoptosis, invasion, metabolism. Its overexpression has been implicated various malignancies, such as lung adenocarcinoma, gastric cancer, pancreatic liver ovarian where it correlates strongly with disease progression. UBE2T facilitates tumorigenesis malignant behaviors by mediating essential functions DNA repair, cell cycle regulation, activation oncogenic signaling pathways. High levels expression are associated poor survival outcomes, highlighting its potential molecular biomarker for cancer prognosis. Increasing evidence suggests that acts an oncogene could serve promising therapeutic target treatment. This review aims to provide detailed overview UBE2T’s structure, functions, mechanisms involved progression well recent developments UBE2T-targeted inhibitors. Such insights may pave way novel strategies diagnosis treatment, enhancing our understanding biology supporting development innovative approaches.

Language: Английский

Citations

3
Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment DOI Creative Commons
Wenqiang Li, Quan Yuan, Mei Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 31, 2024

Lung cancer (LC) is one of the most common worldwide. Tumor-associated macrophages (TAMs) are important component tumor microenvironment (TME) and closely related to stages occurrence, development, metastasis. Macrophages plastic can differentiate into different phenotypes functions under influence signaling pathways in TME. The classically activated (M1-like) alternatively (M2-like) represent two polarization states macrophages. M1 exhibit anti-tumor functions, while M2 considered support cell survival Macrophage involves complex pathways, blocking or regulating these enhance macrophages' effects has become a research hotspot recent years. At same time, there have been new discoveries regarding modulation TAMs towards an phenotype by synthetic natural drug components. Nanotechnology better achieve combination therapy targeted delivery drugs, maximizing efficacy drugs minimizing side effects. Up now, nanomedicines targeting various active substances for reprogramming made significant progress. In this review, we primarily provided comprehensive overview crosstalk between cells LC microenvironment. Additionally, latest advancements novel nano-based systems (NDDSs) that target were also reviewed. Finally, discussed prospects as therapeutic targets barriers clinical translation.

Language: Английский

Citations

2