ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa

Neuropharmacology, Journal Year: 2025, Volume and Issue: 269, P. 110361 - 110361

Published: Feb. 12, 2025

Retinitis pigmentosa (RP) is a hereditary neurodegenerative disease characterized by the degeneration of photoreceptors caused mutations in various genes. Increasing evidence suggests that mitochondrial biogenesis plays critical role many diseases. This study investigated rd1 mice, widely recognized model RP. Male C57BL/6 mice and age-matched were used for vivo experiments, while H2O2 was employed on 661w cells to establish an vitro model. Our findings revealed regulatory PGC-1α/NRF-1/TFAM pathway significantly downregulated mice. Treatment with ZLN005, PGC-1α agonist, markedly improved visual function alleviated thinning retinal outer nuclear layer. Additionally, ZLN005 enhanced restored photoreceptors. Further analysis confirmed rescued photoreceptor promoting through pathway. In summary, our results highlight progression offers potential strategy delay RP maintaining could be combined existing therapies improving treatment outcomes synergistic pathways.

Language: Английский

The interaction between IL-33 and TRIM28 in the regulation of macrophage polarization in an ST2-independent manner

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114318 - 114318

Published: March 6, 2025

Language: Английский