Association of LEF1-AS1 with cardiovascular and neurological complications of COVID-19 DOI Creative Commons
Mélanie Vausort, Andrew I. Lumley,

Hassina Boubakeur

et al.

Journal of Molecular and Cellular Cardiology Plus, Journal Year: 2024, Volume and Issue: 11, P. 100280 - 100280

Published: Dec. 22, 2024

A significant proportion of COVID-19 patients develop long-term complications, particularly cardiovascular and neurological issues. Even though risk factors for developing complications after have been identified, a biomarker to predict these could enable personalized healthcare potentially reduce the disease burden. Easily measurable in blood, long noncoding RNA LEF1-AS1 has recently associated with in-hospital mortality following SARS-CoV - 2 infection holds potential as severity patients. Consequently, we examined LEF1-AS1's ability COVID-19. measured blood by quantitative PCR 104 primo-infected participants from Predi-COVID cohort within 3 days post clinical PCR-confirmed diagnosis. Among them, 35 (34 %) reported at least one persistent symptom or ocular self-administered questionnaire 12 months Blood levels baseline were lower (p = 0.019) compared those who did not report symptoms. Lower symptoms an odds ratio 0.48 (95 % confidence interval 0.28-0.83) logistic regression model adjusted age, sex, comorbidity, moderate baseline. expression was positively correlated frequency naïve T cells negatively effector memory among total CD8+ cells, revealing association between T-cell differentiation SARS-CoV-2 infection. In conclusion, can help predicting 12-month patients, this finding requires validation larger cohorts.

Language: Английский

Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis DOI Creative Commons
Liwei Huang, Huamin Li, Bei He

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 6, 2025

Since its emergence in 2019, COVID-19 has continued to pose significant threats both the physical and mental health of global population, as well healthcare systems worldwide (Raman et al., Eur Heart J 43:1157–1172, 2022). Emerging evidence indicates that may lead post-acute syndrome (PACS) with cardiovascular implications, potentially driven by factors such ACE2 interaction viruses, systemic inflammation, endothelial dysfunction. However, there remains a limited amount research on manifestations PACS, which delay development optimal treatment strategies for affected patients. Therefore, it is crucial investigate prevalence sequelae patients determine whether infection acts an independent risk factor these outcomes. This meta-analysis adhered PRISMA guidelines was registered PROSPERO (CRD42024524290). A systematic search PubMed, Embase, Cochrane Library conducted up March 17, 2024. The primary outcomes included hypertension, palpitations, chest pain, pooled effect estimate reported proportions odds ratios (ORs) 95% confidence intervals (CIs). Sensitivity subgroup analysis were performed assess robustness results identify sources heterogeneity. total 37 studies, encompassing 2,965,467 patients, analysis. Pooled from case–control studies revealed that, compared control group, ORs pain group 4.0 (95% CI: 1.6, 10.0). palpitation hypertension 3.4 1.1, 10.2) 1.7 1.8), respectively. PACS experiencing palpitation, 22% 14%, 33%), 18% 13%, 24%), 19% 12%, 31%), Our findings indicate 15% experience sequelae. Furthermore, significantly increases likelihood developing uninfected individuals. Future should prioritize investigating underlying pathological mechanisms targeted preventive management strategies. CRD42024524290.

Language: Английский

Citations

2
COVID-19 and Disabilities: Impact and the Emergence of Long COVID DOI
Haiyang Li,

Baoqing Sun

Published: Jan. 1, 2025

Language: Английский

Citations

0
Optimizing Clinical Management of COVID-19: A Predictive Model for Unvaccinated Patients Admitted to ICU DOI Creative Commons

Ahmed Farhan,

Khouloud Ayed,

Sara Zayati

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 230 - 230

Published: Feb. 27, 2025

This study investigates the impact of immunological and clinical factors on COVID-19 outcomes among unvaccinated individuals. A cohort 42 patients admitted to an intensive care unit was analyzed, focusing age, comorbidities, inflammatory cytokines (IL-6, TNF-α), anti-SARS-CoV-2 spike protein antibody levels (IgG) assess their influence hospital stay duration, recovery time, complications, mortality rates. The findings revealed that advanced cardiovascular disease, elevated pro-inflammatory significantly heightened risks severe complications mortality. Conversely, low IgG correlated with prolonged stays slower recovery. Multivariate analysis identified high IL-6 TNF-α as strong predictors adverse outcomes. research emphasizes need for early monitoring targeted management strategies mitigate COVID-19, especially high-risk populations.

Language: Английский

Citations

0
Long COVID: General Perceptions and Challenges in Diagnosis and Management DOI Creative Commons

Katia Ozanic,

Aripuanã Sakurada Aranha Watanabe,

Andre Machado

et al.

COVID, Journal Year: 2025, Volume and Issue: 5(3), P. 41 - 41

Published: March 12, 2025

On 11 March 2020, the World Health Organization (WHO) declared a pandemic caused by SARS-CoV-2, raising global health concerns. Reports of persistent and new symptoms following acute phase infection highlighted complexities recovery prompted investigation what is now termed long COVID. Officially recognized WHO in October 2021, COVID presents various implications, though terminology—such as post-COVID syndrome post-acute sequelae COVID-19 (PASC)—remains inconsistent, complicating diagnostic standardization. Long affects an estimated 10% to 30% SARS-CoV-2-infected individuals, with common including fatigue, dyspnea, cognitive dysfunction, joint pain, all which significantly impair quality life. Public perception influenced factors like education history, while misinformation stigma hinder accurate diagnosis treatment. The absence biomarkers overlap other post-viral syndromes further complicate clinical recognition. Experts emphasize need for refined criteria integrated strategies combining biomedical research, public policy, educational initiatives improve management, address healthcare inequalities, mitigate impacts This review unveils state art knowledge gaps encourage discussion, aim achieving better decision-making awareness related

Language: Английский

Citations

0
Drug Repurposing for COVID-19 by Constructing a Comorbidity Network with Central Nervous System Disorders DOI Open Access
Jing Qian, Bin Yang, Shuo Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8917 - 8917

Published: Aug. 16, 2024

In the post-COVID-19 era, treatment options for potential SARS-CoV-2 outbreaks remain limited. An increased incidence of central nervous system (CNS) disorders has been observed in long-term COVID-19 patients. Understanding shared molecular mechanisms between these conditions may provide new insights developing effective therapies. This study developed an integrative drug-repurposing framework COVID-19, leveraging comorbidity data with CNS disorders, network-based modular analysis, and dynamic perturbation analysis to identify drug targets candidates against SARS-CoV-2. We constructed a network based on literature collection, including COVID-19-related proteins genes associated Alzheimer’s disease, Parkinson’s multiple sclerosis, autism spectrum disorder. Functional module detection annotation identified primarily involved protein synthesis as key target module, utilizing connectivity map data. Through construction weighted drug–target ubiquitin–carboxy-terminal hydrolase L1 emerged target. Molecular dynamics simulations suggested pregnenolone BRD-K87426499 two COVID-19. introduces dynamic-perturbation-network-based approach by incorporating disorders.

Language: Английский

Citations

1
Risk factors for long COVID syndrome in postmenopausal women with previously reported diagnosis of COVID-19 DOI

Marian L. Neuhouser,

Hamza Butt, Chengcheng Hu

et al.

Annals of Epidemiology, Journal Year: 2024, Volume and Issue: 98, P. 36 - 43

Published: Aug. 12, 2024

Language: Английский

Citations

0
Prevalence, duration, and factors influencing post-COVID conditions among patients at several public hospitals, Alexandria governorate, Egypt 2022-2023. DOI Creative Commons
Rasha Ashmawy, Yousra A. El‐Maradny,

Amira Tahio

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38764 - e38764

Published: Sept. 30, 2024

Language: Английский

Citations

0
A Real-Life Study in Patients Newly Diagnosed with Autoimmune Hashimoto’s Thyroiditis: Analysis of Asthenia as Admission Complaint DOI Creative Commons

Ana Valea,

Mihai Costăchescu,

Mihaela Stanciu

et al.

Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1380 - 1380

Published: Oct. 27, 2024

Background: Amid the large panel of autoimmune thyroid diseases, Hashimoto’s thyroiditis (HT) represents a major point across multidisciplinary daily practice. When it comes to clinical picture, particularly in regard asthenia (also described as “fatigue” or “decreased energy”), differential diagnosis is challenging, and meticulous anamnesis should be backed up by focused lab investigations. Our objective was analyze newly diagnosed patients with HT relationship presence an admission complaint. Methods: This retrospective, multi-centric, real-life study conducted secondary endocrine units (university hospitals) from July 2022 2023. The exclusion criteria were COVID-19 infection; active malignancy, etc. Results: cohort (N = 120) included group (AS, 49.2%) non-AS similar age (49.3 ± 14.7 vs. 47.1 14.8 y, p 0.426). Headache more frequent AS (35.6% 18%, 0.03). Thyroid function HT-related antibodies assays between groups show no correlation serum total cholesterol triglycerides, respectively. TSH levels did not vary among sub-groups (p 0.701). One third studied population affected hypothyroidism (TSH > 4.5 μIU/mL), being seen at higher rate (39%) (23%). Total positively correlated patients’ (r 0.180, 0.049) triglycerides 120; r 0.324, < 0.001), found only 0.246, 0.006, respectively, 0.319, 0.001). Conclusions: analysis pinpointed fact that, practice, complaint seems less indicator underlying dysfunction level against without full picture thyrotoxicosis myxoedema.

Language: Английский

Citations

0
The effects of a home telerehabilitation-based program on the cardiopulmonary function and quality of life in post-COVID-19 patients DOI Creative Commons

Thanaporn Semphuet,

Netchanok Jianramas,

Veeranoot Nissapatorn

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(22), P. e40453 - e40453

Published: Nov. 1, 2024

Relatively few studies have explored the impact of home telerehabilitation-based (HTB) programs on patients with post-COVID-19 syndrome. Thus, this study aimed to investigate effect HTB cardiopulmonary function, body composition, muscle strength, and quality life (QoL)

Language: Английский

Citations

0
Holistic AI-Based Prediction Model for COVID-19 Drug Efficacy in Patients with Comorbidities DOI

H. S. Suresh Kumar,

C N Pushpa,

J Thriveni

et al.

SN Computer Science, Journal Year: 2024, Volume and Issue: 5(8)

Published: Dec. 2, 2024

Language: Английский

Citations

0