Foods,
Journal Year:
2024,
Volume and Issue:
13(21), P. 3427 - 3427
Published: Oct. 28, 2024
This
study
examines
the
impact
of
mung
bean
(Vigna
radiata)
protein
consumption
on
endothelial
function
in
middle-aged
adults,
focusing
antioxidant
enzyme
activity
and
anti-inflammatory
markers.
Mung
beans
have
shown
promise
enhancing
cardiovascular
function,
lowering
blood
pressure,
improving
lipid
profiles,
but
underlying
mechanisms
these
functions
remain
unclear.
Conducted
as
a
three-arm
randomized,
double-blind,
placebo-controlled
trial,
this
involved
male
female
participants
aged
45
to
60
assigned
them
consume
either
placebo
or
functional
drink
containing
10
15
g
daily
for
six
weeks.
Vasodilation
was
assessed
using
flow-mediated
dilation
(FMD),
oxidative
stress
markers,
activity,
inflammatory
markers
were
measured
at
baseline
after
intervention.
The
results
indicate
that
weeks
significantly
benefits
healthy
adults
by
reducing
mediators’
expression.
Additionally,
increase
brachial
artery
diameter
following
FMD
indicates
improved
function.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1131 - 1131
Published: Sept. 19, 2024
Vitis
vinifera
L.,
commonly
known
as
grapes,
is
one
of
the
most
widely
cultivated
crops
worldwide,
with
over
80%
used
for
wine
production.
However,
winemaking
process
generates
substantial
residues,
including
grape
pomace
(GP),
lees,
and
wastewater,
which
can
pose
significant
environmental
economic
challenges.
Among
these,
GP
stands
out
not
only
a
waste
product
but
also
rich
source
polyphenols—bioactive
compounds
recognized
antioxidant
anti-inflammatory
properties.
Recent
advancements
have
expanded
application
GP-derived
extracts,
particularly
in
health
food
industries,
due
to
their
potent
bioactive
This
review
provides
comprehensive
overview
valorization
GP,
focusing
on
its
phenolic
composition
therapeutic
potential.
It
evokes
innovative,
environmentally
friendly
extraction
techniques
integrated
methods
chemical
analysis
these
valuable
compounds.
Additionally,
benefits
polyphenols
are
explored,
recent
experimental
findings
examining
metabolism
highlighting
key
role
gut
microbiota
processes.
These
insights
contribute
deeper
understanding
biological
activity
extracts
underscore
growing
significance
high-added-value
product.
By
illustrating
how
by-products
be
transformed
into
natural
agents,
this
emphasizes
importance
sustainable
development
eco-friendly
management
practices,
significantly
contributing
advancement
circular
economy.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 203 - 203
Published: Feb. 10, 2025
The
interplay
between
oxidative
stress
and
adipogenesis
is
a
critical
factor
in
the
development
of
obesity
its
associated
metabolic
disorders.
Excessive
reactive
oxygen
species
(ROS)
disrupt
key
transcription
factors
such
as
peroxisome
proliferator-activated
receptor
gamma
(PPARγ)
CCAAT/enhancer-binding
protein
alpha
(C/EBPα),
impairing
lipid
metabolism,
promoting
adipocyte
dysfunction,
exacerbating
inflammation
insulin
resistance.
Antioxidants,
classified
endogenous
(e.g.,
glutathione,
superoxide
dismutase,
catalase)
exogenous
polyphenols,
flavonoids,
vitamins
C
E),
are
pivotal
mitigating
these
effects
by
restoring
redox
balance
preserving
functionality.
Endogenous
antioxidants
neutralize
ROS
safeguard
cellular
structures;
however,
under
heightened
stress,
defenses
often
insufficient,
necessitating
dietary
supplementation.
Exogenous
derived
from
plant-based
sources,
polyphenols
vitamins,
act
through
direct
scavenging,
upregulation
antioxidant
enzymes,
modulation
signaling
pathways
like
nuclear
kappa
B
(NF-κB)
PPARγ,
reducing
peroxidation,
inflammation,
dysfunction.
Furthermore,
they
influence
epigenetic
regulation
transcriptional
networks
to
restore
differentiation
limit
accumulation.
Antioxidant-rich
diets,
including
Mediterranean
diet,
strongly
with
improved
health,
reduced
rates,
enhanced
sensitivity.
Advances
personalized
therapies,
guided
biomarkers
supported
novel
delivery
systems,
present
promising
avenues
for
optimizing
therapeutic
interventions.
This
review,
"Crosstalk
Between
Antioxidants
Adipogenesis:
Mechanistic
Pathways
Their
Role
Metabolic
Health",
highlights
mechanistic
which
regulate
enhance
health.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(3), P. 530 - 530
Published: Jan. 31, 2025
The
pathophysiology
of
fibromyalgia,
a
condition
that
causes
chronic
pain
throughout
the
body,
involves
abnormal
signaling,
genetic
predispositions,
and
neuroendocrine
function,
significantly
impairing
quality
life.
Fibromyalgia
is
commonly
characterized
by
musculoskeletal
pain,
fatigue,
severe
sleep
alterations.
Changes
in
central
processing
sensory
input
defects
endogenous
inhibition
could
be
basis
enhanced
persistent
sensitivity
individuals
with
fibromyalgia.
term
syndrome
was
chosen
as
an
umbrella
for
fibromyalgia
related
illnesses,
including
myalgic
encephalomyelitis/chronic
fatigue
syndrome,
migraine,
irritable
bowel
syndrome.
Given
substantial
impact
on
health,
there
need
new
prevention
treatment
strategies,
particularly
those
involving
bioavailable
nutraceuticals
and/or
phytochemicals.
This
approach
important
considering
adverse
effects
current
pharmaceutical
treatments,
such
antidepressants
anticonvulsants,
which
can
lead
to
physical
dependence
tolerance.
Natural
products
have
recently
been
considered
design
innovative
analgesics
antinociceptive
agents
manage
pain.
Polyphenols
show
promise
management
neuropathic
especially
how
anti-inflammatory
corticosteroids
nonsteroidal
medical
drugs,
are
effective
only
when
inflammatory
processes
coexist
not
recommended
primary
Planta Medica,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Abstract
Green
tea
catechins
are
bioactive
polyphenolic
compounds
that
possess
a
number
of
biological
activities
and
potential
health
benefits.
This
review
will
focus
on
discussing
the
effects
green
catechins,
with
particular
emphasis
clinical
studies
evaluate
their
anticancer
potential.
Epigallocatechin
gallate
(EGCG),
either
as
stand-alone
treatment
or
in
conjunction
conventional
therapies,
represents
promising
alternative
strategy
for
management
leukaemia.
was
based
search
scientific
sources
indexed
databases
PubMed
Scopus
using
following
keywords:
‘Camellia
sinensis’,
‘tea
catechins’,
‘anticancer’,
‘antioxidant’,
‘hematological
cancer’,
‘leukaemia’
combination.
A
deeper
comprehension
multifaceted
mechanisms
findings
research
could
facilitate
development
novel
strategies
integration
into
practice,
thus
enhancing
outcomes
patients
Natural Product Communications,
Journal Year:
2025,
Volume and Issue:
20(3)
Published: March 1, 2025
Diabetes
mellitus
is
a
long-term
metabolic
condition
marked
by
chronically
high
levels
of
glucose
in
the
blood
due
to
insufficient
synthesis
insulin
or
impaired
function.
Throughout
history,
several
civilizations
have
used
traditional
medicinal
plants
treat
and
control
diabetes.
This
paper
offers
thorough
review,
date,
antidiabetic
natural
compounds
origin,
specifically
highlighting
their
reported
modes
mechanisms
action
therapeutic
possibilities,
with
view
fast-tracking
possibility
transition
pharmaceutical
products
for
human
use.
Phytochemicals
such
as
flavonoids,
alkaloids,
terpenoids,
glycosides
notable
effects.
They
been
shown
via
many
processes,
including
boosting
secretion,
improving
sensitivity,
blocking
absorption
\gastrointestinal-tract,
regulating
carbohydrate
metabolism.
Unlike
earlier
reviews,
this
current
one,
addition
chemistry
proposed
action,
also
x-rays
effectiveness
safety
these
chemicals
combining
evidences
from
laboratory
research,
animal
experiments,
clinical
trials.
Several
substances,
Demethoxycurcumin,
Trigonelline,
Ginsenosides,
progressed
trials,
while
others
like
Allicin
Polypeptide-p
at
bedside.
Bisdemethoxycurcumin,
Vicine,
Gymnemosides,
are
now
preclinical
trial
phase,
suggesting
that
research
still
ongoing
there
promise
future
application.
The
review
highlights
evolution
diabetes
management,
potential
improve
treatment.
It
suggests
incorporating
plant-derived
into
treatments,
reducing
dependence
on
drugs
adverse
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 24, 2025
Background
Spinal
cord
injury
(SCI)
significantly
impairs
individuals’
sensorimotor
functions,
hindering
daily
activities.
Current
therapeutic
options
often
demonstrate
limited
efficacy
and
lead
to
undesirable
side
effects.
Emerging
research
highlights
the
potential
of
anthocyanins,
especially
pelargonidin,
which
possess
neuroprotective,
anti-inflammatory,
antioxidant
properties
beneficial
for
neurological
conditions.
Purpose
This
study
sought
explore
impact
intrathecal
administration
pelargonidin
on
recovery
sensory-motor
functions
associated
disorders
in
a
rat
model
SCI
through
neuroprotective
effects
regulating
inflammatory/oxidative
stress
mediators.
Materials
methods
In
total,
35
male
Wistar
rats
were
divided
into
five
groups:
sham,
SCI,
three
treatment
groups
receiving
different
concentrations
(1,
2,
4
mM)
once
day
0
after
surgery/injury.
Weight
changes
assessed
behavioral
analyses
done,
including
hot
plate
tests,
acetone
drop
von
Frey
inclined
plane
as
well
Basso,
Beattie,
Bresnahan
(BBB)
scores,
weekly
up
28
post-injury.
On
28,
serum
levels
nitrite,
catalase,
glutathione
matrix
metalloproteinase
(MMP)
assays
histological
evaluations
done.
Results
discussion
Pelargonidin
attenuated
neuropathic
pain,
improved
motor
performance,
reduced
weight
loss
with
SCI.
Biochemical
demonstrated
increased
catalase/glutathione
level,
MMP2
activity,
while
decreased
nitrite
level
MMP9
activity.
Histological
showed
an
enhancement
number
neurons
ventral
horn
spinal
highlighting
its
neurogenic
Conclusion
makes
substantial
benefits
following
by
accelerating
recovery.
effect
is
likely
due
strong
antioxidant,
properties.
