Mung Bean Functional Protein Enhances Endothelial Function via Antioxidant Activity and Inflammation Modulation in Middle-Aged Adults: A Randomized Double-Blind Trial DOI Creative Commons
Supaporn Muchimapura, Wipawee Thukham-mee, Sophida Phuthong

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3427 - 3427

Published: Oct. 28, 2024

This study examines the impact of mung bean (Vigna radiata) protein consumption on endothelial function in middle-aged adults, focusing antioxidant enzyme activity and anti-inflammatory markers. Mung beans have shown promise enhancing cardiovascular function, lowering blood pressure, improving lipid profiles, but underlying mechanisms these functions remain unclear. Conducted as a three-arm randomized, double-blind, placebo-controlled trial, this involved male female participants aged 45 to 60 assigned them consume either placebo or functional drink containing 10 15 g daily for six weeks. Vasodilation was assessed using flow-mediated dilation (FMD), oxidative stress markers, activity, inflammatory markers were measured at baseline after intervention. The results indicate that weeks significantly benefits healthy adults by reducing mediators’ expression. Additionally, increase brachial artery diameter following FMD indicates improved function.

Language: Английский

Network Pharmacology, Molecular Docking, and Molecular Dynamics Study to Explore the Effect of Resveratrol on Type 2 Diabetes DOI
Fernando Martínez‐Esquivias, Juan Manuel Guzmán‐Flores, Andrés Reyes‐Chaparro

et al.

Journal of Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 126(1)

Published: Sept. 20, 2024

ABSTRACT This network pharmacology study represents a significant step in understanding the potential of Resveratrol as an antidiabetic agent and its molecular targets. Targets for Type 2 diabetes were obtained from MalaCards DisGeNET databases, while targets sourced STP CTD databases. Subsequently, we performed matching to identify common disease‐compound The identified genes analyzed using ShinGO‐0.76.3 database functional enrichment analysis KEGG pathway mapping. A protein−protein interaction was then constructed Cytoscape software, hub identified. These subjected docking dynamic simulations AutoDock Vina Gromacs software. According analysis, influences insulin receptors, endoplasmic reticulum functions, oxidoreductase activity is involved estrogen HIF‐1 pathways. Ten identified, including ESR1 , PTGS2 SRC NOS3 MMP9 IGF1R CYP19A1 MTOR MMP2, PIK3CA . proteins associated with these exhibited high dynamics showed stable ESR1, MMP9, PIK3CA, PTGS2. In conclusion, our work enhances Resveratrol, which future studies should experimentally corroborate.

Language: Английский

Citations

1
Phenolic Compositions of Different Fractions from Coffee Silver Skin and Their Antioxidant Activities and Inhibition towards Carbohydrate-Digesting Enzymes DOI Creative Commons

Shiyu Dong,

Lixin Ding,

Xiuqing Zheng

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(19), P. 3083 - 3083

Published: Sept. 27, 2024

Seeking food-derived antioxidants and inhibitors of α-glucosidase α-amylase has been recognized as an effective way for managing diabetes. Coffee silver skin (CSS) is rich in phenolic compounds, which may be potential agents inhibition. But whether phenolics different forms show similar bioactivity remains unknown. In this study, compounds CSS were extracted free (FPs), esterified (EPs), bound (BPs). The profiles antioxidant activities them investigated. Their inhibitory effects on analyzed, the mechanisms elucidated by molecular docking dynamic simulation. Results showed that FPs exhibited best ability α-amylase. A total 17 identified with 3-caffeoylquinic acid, 4-feruloylquinic dicaffeoylquinic acids dominant ones. Typical could bind to through hydrogen bonds form hydrophobic interaction several key amino acid residues. addition, 3,4-dicaffeoylquinic might principal components account effect α-glucosidase. results study provide some scientific support utilization a health-beneficial component functional food development type 2 diabetes mellitus management.

Language: Английский

Citations

0
Phytochemical Assessment and Potential Pharmacological Activity of Moringa Oleifera Extract DOI

Aziza Alisherovna Turakhanova,

Fatima Khamzatovna Bidzhieva,

Daria Vasilyevna Solovyeva

et al.

Pharmacophore, Journal Year: 2024, Volume and Issue: 15(4), P. 46 - 53

Published: Jan. 1, 2024

Language: Английский

Citations

0
Mung Bean Functional Protein Enhances Endothelial Function via Antioxidant Activity and Inflammation Modulation in Middle-Aged Adults: A Randomized Double-Blind Trial DOI Creative Commons
Supaporn Muchimapura, Wipawee Thukham-mee, Sophida Phuthong

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3427 - 3427

Published: Oct. 28, 2024

This study examines the impact of mung bean (Vigna radiata) protein consumption on endothelial function in middle-aged adults, focusing antioxidant enzyme activity and anti-inflammatory markers. Mung beans have shown promise enhancing cardiovascular function, lowering blood pressure, improving lipid profiles, but underlying mechanisms these functions remain unclear. Conducted as a three-arm randomized, double-blind, placebo-controlled trial, this involved male female participants aged 45 to 60 assigned them consume either placebo or functional drink containing 10 15 g daily for six weeks. Vasodilation was assessed using flow-mediated dilation (FMD), oxidative stress markers, activity, inflammatory markers were measured at baseline after intervention. The results indicate that weeks significantly benefits healthy adults by reducing mediators’ expression. Additionally, increase brachial artery diameter following FMD indicates improved function.

Language: Английский

Citations

0