The Interaction Between Microbiota and Stem Cells on Progression of Osteoarthritis and Engineered Stem Cell for Enhancing Osteoarthritis Treatment

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3219 - 3234

Published: March 1, 2025

Osteoarthritis (OA) is characterized by the degeneration of articular cartilage caused several factors which novel most trends include microbiota. Specific microbiota and role in development OA less clear. The presumed to influence occurrence progression mainly via immune modulation. In recent years, bone marrow mesenchymal stem cells (MSCs) have shown great potential for treatment OA, however, therapeutic efficiency has been seriously affected harsh microenvironment joint cavity. At present, many strategies used enhance function MSCs, among them, engineering are a promising method. Therefore, this review focuses on latest research how affects cell repair, use engineered MSCs OA. addition, can exosomes as strategy treating Our provides comprehensive perspective therapy

Language: Английский

LNP-mRNA delivers TNF-α antibody to deep cartilage and protects against osteoarthritis

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 156723 - 156723

Published: Oct. 16, 2024

Language: Английский

Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells

Regenerative Therapy, Journal Year: 2024, Volume and Issue: 28, P. 101 - 114

Published: Dec. 6, 2024

Language: Английский