Cited by Chinese yam (Dioscorea) polysaccharide ameliorates ulcerative colitis in mice via modulating disorders of intestinal microecology and metabolism

Immune-Mediated Bidirectional Causality Between Inflammatory Bowel Disease and Chronic Periodontitis: Evidence from Mendelian Randomization and Integrative Bioinformatics Analysis DOI

Zhijun Feng,

Zihan Chen,

Xiaoxu Wang

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 476 - 476

Published: Feb. 15, 2025

Background/Objectives: A bidirectional association between inflammatory bowel disease (IBD) and periodontitis has been observed, yet their causal relationship remains unclear. This study aimed to investigate the potential links these two conditions through comprehensive genetic molecular analyses. Methods: We conducted a Mendelian randomization (MR) analysis integrated with bioinformatics approaches. The relationships were primarily evaluated using inverse variance weighting (IVW), complemented by multiple sensitivity analyses assess robustness of findings. Additionally, we performed differential gene expression RNA sequencing data identify co-expressed genes shared mediators IBD periodontitis, followed pathway enrichment analysis. Results: Bidirectional MR revealed significant associations (p-value < 0.05). Sensitivity demonstrated consistency findings, no evidence heterogeneity or horizontal pleiotropy > Integrated identified key immune regulators, particularly interleukin 1 beta (IL1B) C-X-C motif chemokine receptor 4 (CXCR4), signaling pathways, including tumor necrosis factor (TNF-α) 17 (IL17), as mechanisms underlying conditions. Conclusions: Our findings provide supporting periodontitis. Transcriptomic pathological crucial regulatory factors common both diseases. These insights enhance our understanding interplay potentially informing new therapeutic strategies for

Language: Английский

Citations

Bifidobacterium longum subspecies infantis CCFM111 mitigates allergic rhinitis in mice through adjusting intestinal microecology and elevating indole-3-carboxaldehyde levels DOI

Yu Wang, Zhangming Pei, Xiaomeng Li

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106188 - 106188

Published: Feb. 1, 2025

Language: Английский

Citations

Clinical significance and pathogenesis of GBP5 in infectious mononucleosis associated liver injury DOI

Zhiyong Li,

Jiamei Tang,

Yulan Ma

et al.

The Italian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2025, Volume and Issue: 51(1)

Published: March 12, 2025

Abstract Background Infectious mononucleosis (IM) is a common disease in children; however, liver injury its most complication. However, the pathogenesis of IM complicated with ambiguous. Thus, this study aimed to explore potential mechanism IM-associated injury. Methods This was conducted at Children’s Hospital Soochow University by collecting peripheral blood 70 hospitalized children IM. These patients were categorized into (LIG, n = 35) and non-liver groups (NLIG, 35), respectively. Subsequently, PBMCs plasma separated obtained. transcriptome sequencing performed two (5 cases each group), significantly differentially expressed genes (DEGs) screened. Additionally, GO function enrichment, KEGG enrichment GSEA analyses performed. RT-PCR helped detect relative GBP5, NLRP3 caspase-1 expressions (30 group) while groups’ caspase-1, IL-1β IL-18 levels measured ELISA. clinical laboratory datas 60 evaluated. Results Transcriptome results showed that 171 DEGs screened NLIG group, compared LIG. Among them, 154 up-regulated, 17 down-regulated, correlated NOD-like receptor signaling pathway. Statistically significant differences observed white cell lymphocyte counts, CD3 + CD4 T cells, CD8 alanine aminotransferase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH) ( p < 0.05). Compared NLIG, PBMCs, as well levels, higher LIG 0.001). A correlation analysis revealed positive GBP5 LDH, ALT, AST, cells Conclusions Our findings demonstrate contributes through NLRP3-dependent

Language: Английский

Citations

Role of guanylate-binding protein 5 in inflammatory diseases, immune diseases, cancers, and its potential therapeutic implications DOI

Xufan Sun,

Guiyuan Jin, Huihui Zhou

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

Citations

From Intestinal Barrier to Inflammatory Response: Combined Impact of Deoxynivalenol and Heat Stress in Mice DOI

Han Shi,

A. Q. Liu, Kang Feng

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

Effects of Lactobacillus plantarum-loaded W1/O/W2 emulsions stabilized by ultrasonically treated pea protein on DSS-induced colitis in mice DOI

Chao Zhang, Nan Zhang, Yu Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143956 - 143956

Published: May 8, 2025

Language: Английский

Citations

Chinese yam (Dioscorea) polysaccharide ameliorates ulcerative colitis in mice via modulating disorders of intestinal microecology and metabolism DOI

C Zhang,

Ying Shu, Yang Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144110 - 144110

Published: May 1, 2025

Language: Английский

Citations