Identification of Alterations in the Expression of Genes Related to the Implant Failure in Spanish Patients with Down Syndrome and Periodontal Disease
Genes,
Journal Year:
2025,
Volume and Issue:
16(2), P. 122 - 122
Published: Jan. 22, 2025
Background:
Individuals
with
Down
syndrome
exhibit
a
higher
prevalence
of
periodontal
disease,
which
can
lead
to
implant
loss.
This
study
aims
identify
genetic
markers
associated
loss
in
these
patients,
providing
insight
into
potential
predictive
and
therapeutic
approaches.
Methods:
A
systematic
analysis
was
conducted,
including
both
clinical
data
from
patients
history
dental
implants.
Genetic
profiling
performed
using
Transcriptome
Analysis
Console
(TAC
version
4.0
Applied
BiosystemsTM,
Thermo
Fisher
Scientific,
Waltham,
MA,
USA),
focusing
on
genes
previously
implicated
disease
bone
metabolism.
Statistical
identified
correlations
between
variants
survival
rates.
Results:
The
revealed
statistically
significant
alterations
several
related
inflammation
remodeling.
Key
findings
included
the
expression
MMP15,
MMP17,
S100B,
GHR,
DNAH6,
ZCCHC14
failure.
These
were
strongly
correlated
compromised
osseointegration
underline
role
predisposition
failure
implants
among
individuals
syndrome.
Conclusions:
markers,
particularly
those
involved
metabolism,
play
critical
disease.
Recognizing
aid
early
diagnosis
personalized
treatment
strategies,
potentially
improving
success
Language: Английский
Potential target within the tumor microenvironment - MT1-MMP
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 24, 2025
Matrix
metalloproteinases
are
integral
to
the
modification
of
tumor
microenvironment
and
facilitate
progression
by
degrading
extracellular
matrix,
releasing
cytokines,
influencing
recruitment
immune
cells.
Among
matrix
metalloproteinases,
membrane-type
metalloproteinase
1
(MT1-MMP/MMP14)
is
first
identified
MMP
acts
as
an
essential
proteolytic
enzyme
that
enables
infiltration
metastatic
progression.
Given
pivotal
role
MT1-MMP
in
correlation
between
its
overexpression
tumors
unfavorable
prognoses
across
multiple
cancer
types,
a
comprehensive
understanding
potential
functional
mechanisms
essential.
This
knowledge
will
aid
advancement
diverse
anti-tumor
therapies
aimed
at
targeting
MT1-MMP.
Although
contemporary
research
has
highlighted
considerable
targeted
therapy,
studies
pertaining
application
cell
therapy
remain
relatively
limited.
In
this
review,
we
delineate
structural
characteristics
regulatory
expression,
well
biological
significance
tumorigenesis.
Finally,
discussed
current
status
prospects
Language: Английский