Anti-Inflammatory Effects of Curcumin-Based Nanoparticles Containing α-Linolenic Acid in a Model of Psoriasis In Vitro DOI Open Access
Simona Serini, Sonia Trombino, Roberta Cassano

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 692 - 692

Published: Feb. 14, 2025

Background/Objectives. Psoriasis is a common chronic skin inflammatory disorder pathogenetically associated with genetic, environmental, and immunological factors. The hallmarks of psoriatic lesions include sustained inflammation related to alterations in the innate adaptive immune response, uncontrolled keratinocyte proliferation, differentiation, death, as well dysregulated crosstalk between cells keratinocytes. In search novel therapeutic strategies based on use natural products dietary components combine available conventional innovative therapeutics, we explored anti-inflammatory, antioxidant, immunomodulatory activities Curcumin (CU)-based solid lipid nanoparticles (SLNs) carrying omega-3 fatty acid linolenic (LNA) an vitro model psoriasis that had been previously constructed characterized by us. Methods. This consists differentiated THP-1 macrophages (Mφs) NCTC-2544 keratinocytes exposed or not conditioned medium (CM) from Mφs treated Toll-like receptor-7 ligand imiquimod (IMQ). Results. Mφs, treatment CU-LNA-SLNs inhibited IMQ-induced expression proinflammatory cytokines (IL-23, IL-8, IL-6: 43%, 26.5% 73.7% inhibition, respectively, vs IMQ-treated Mφs), hyperproliferative response (12.8% inhibition Mφs) increase cell death observed Mφ-derived CM (64.7% inhibition). Moreover, same conditions, reverted control levels increased two markers ferroptosis, form recently involved pathogenesis (TFRC MDA: 13.4% 56.1% respectively). Conclusions. These results suggest could inhibit inflammation, hyperproliferation lesions, be considered new possible strategy for further evaluated topic vivo.

Language: Английский

Anti-Inflammatory Effects of Curcumin-Based Nanoparticles Containing α-Linolenic Acid in a Model of Psoriasis In Vitro DOI Open Access
Simona Serini, Sonia Trombino, Roberta Cassano

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 692 - 692

Published: Feb. 14, 2025

Background/Objectives. Psoriasis is a common chronic skin inflammatory disorder pathogenetically associated with genetic, environmental, and immunological factors. The hallmarks of psoriatic lesions include sustained inflammation related to alterations in the innate adaptive immune response, uncontrolled keratinocyte proliferation, differentiation, death, as well dysregulated crosstalk between cells keratinocytes. In search novel therapeutic strategies based on use natural products dietary components combine available conventional innovative therapeutics, we explored anti-inflammatory, antioxidant, immunomodulatory activities Curcumin (CU)-based solid lipid nanoparticles (SLNs) carrying omega-3 fatty acid linolenic (LNA) an vitro model psoriasis that had been previously constructed characterized by us. Methods. This consists differentiated THP-1 macrophages (Mφs) NCTC-2544 keratinocytes exposed or not conditioned medium (CM) from Mφs treated Toll-like receptor-7 ligand imiquimod (IMQ). Results. Mφs, treatment CU-LNA-SLNs inhibited IMQ-induced expression proinflammatory cytokines (IL-23, IL-8, IL-6: 43%, 26.5% 73.7% inhibition, respectively, vs IMQ-treated Mφs), hyperproliferative response (12.8% inhibition Mφs) increase cell death observed Mφ-derived CM (64.7% inhibition). Moreover, same conditions, reverted control levels increased two markers ferroptosis, form recently involved pathogenesis (TFRC MDA: 13.4% 56.1% respectively). Conclusions. These results suggest could inhibit inflammation, hyperproliferation lesions, be considered new possible strategy for further evaluated topic vivo.

Language: Английский

Citations

0