Scutellarin: pharmacological effects and therapeutic mechanisms in chronic diseases DOI Creative Commons

Shanshan Nie,

Shan Zhang, Ruipeng Wu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 7, 2024

Scutellarin (SCU), a flavonoid glucuronide derived from Scutellaria barbata and Erigeron breviscapus , exhibits broad pharmacological effects with promising therapeutic potential in treating various chronic diseases. It has demonstrated efficacy modulating multiple biological pathways, including antioxidant, anti-inflammatory, anti-apoptotic, vasodilatory mechanisms. These protective roles make SCU valuable compound diseases such as cerebrovascular diseases, cardiovascular neurodegenerative disorders, metabolic Despite its multi-targeted effects, faces challenges low bioavailability limited clinical data, which hinder widespread application. Current research supports to prevent oxidative stress, reduce inflammatory responses, enhance cell survival cells rats. However, more comprehensive studies are required clarify molecular mechanisms develop strategies that for use. could emerge potent agent the treatment of complex pathophysiological This review examines current literature on provide understanding activity, action,

Language: Английский

The emerging role of 12/15-lipoxygenase in ischemic stroke DOI Creative Commons

Xuening Wang,

Qiuji Shao,

Yuan Gao

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111194 - 111194

Published: Jan. 1, 2025

The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), member of the lipoxygenase family that metabolizes acid, has been implicated in pathogenesis numerous central nervous system (CNS) diseases. Ischemic stroke devastating disease which occlusion cerebral arteries leads to series pathophysiological changes brain tissue, triggering an cascade within results neuroinflammation. Prior research shown 12/15-LOX levels are elevated following stroke. In this review, we elaborate on key pathological mechanisms unfold ischemic stroke, including neuroinflammation, oxidative stress, neuronal apoptosis, and blood-brain barrier disruption, present evidence demonstrating inhibition could be used treat through various avenues. Furthermore, list currently available inhibitors preclinical or clinical applications, offering novel insights for early diagnosis, prognosis evaluation, targeted therapy neurological

Language: Английский

Citations

0
Toxicity Mechanisms of Microplastic and Its Effects on Ruminant Production: A Review DOI Creative Commons

Mao-Sen Su,

Shangquan Gan, Rui Gao

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 462 - 462

Published: March 21, 2025

Plastic pollution has become one of the major environmental problems facing human beings in world today. waste accumulated environment forms plastic particles different sizes due to farming activities, climate change, ultraviolet light, microbial degradation, and animal chewing. The caused by microplastics a problem recent years, it is also research hotspot field ecological environment. More more studies have found that ruminants are exposed for long time, which seriously threaten their healthy growth. This paper introduces current situation pollution; properties effects on environment, beings, animals; summarizes types toxicity mechanisms microplastics; concludes main ways enter harm them. In addition, shortcomings future development summarized prospected provide theoretical reference related alleviating influence ruminant production.

Language: Английский

Citations

0
Proteomic analysis of whole blood to investigate the therapeutic effects of nervonic acid on cerebral ischemia-reperfusion injury in rats DOI Creative Commons
Qingqing Li,

Fengrong Zhang,

Xianyu Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 28, 2025

Introduction Blood proteomics offers a powerful approach for identifying disease-specific biomarkers. However, no reliable blood markers are currently available the diagnosis stroke. Nervonic acid (NA), vital long-chain monounsaturated fatty found in mammalian nervous tissue, shows promising therapeutic potential neurological disorders. This study aimed to develop methodology whole identify early warning biomarkers and evaluate drug treatment efficacy. Methods After modeling via classic thread embolization method, samples were collected from rats. Morphological assessments of brain tissue indicated that NA significantly mitigated neuronal damage The differential protein expression profile was analyzed using Liquid Chromatography—Tandem Mass Spectrometry (LC-MS/MS) proteomics. Results ZZZGene Ontology (GO) analysis revealed that, compared ginkgo biloba extract (EGb), proteins differentially expressed under intervention predominantly involved oxidative stress response calcium-dependent adhesion processes. Key targets middle cerebral artery occlusion (MCAO) models included ENO1, STAT3, NME2, VCL, CCT3. Discussion proteomic provides comprehensive understanding profiles associated with disease states, offering valuable insights into enabling evaluation EGb Our findings underscore protective effects against ischemia-reperfusion injury highlight its as

Language: Английский

Citations

0
Targeting the Ischemic Core: A Therapeutic Microdialytic Approach to Prevent Neuronal Death and Restore Functional Behaviors DOI Open Access

May‐Jywan Tsai,

Dann‐Ying Liou, Li-Yu Fay

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3821 - 3821

Published: April 17, 2025

Ischemic stroke leads to cerebral ionic imbalance, increases acidosis, oxidative stress and release of glutamate inflammatory mediators. Removing solute or stimulants from the ischemic core may block cell-damaging events confer neuroprotection. In this study, we developed a minimally invasive therapeutic microdialysis (tMD) method, choosing include serum albumin in buffer because it is multifunctional protein with osmotic properties. Aiming at core, continuous perfusion supplemented agents removes mediators inflammation/cell damage/death lesion. This tMD treatment significantly removed zinc ions thereby reducing infarct volumes affording high-grade neurobehavioral protection against stroke. The effectively protected neurons reduced microglial activation. Furthermore, approach extended window protect beyond 6 h after onset. These findings support potential clinical feasibility applying patients stroke, potentially without adverse effects.

Language: Английский

Citations

0
Scutellarin: pharmacological effects and therapeutic mechanisms in chronic diseases DOI Creative Commons

Shanshan Nie,

Shan Zhang, Ruipeng Wu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 7, 2024

Scutellarin (SCU), a flavonoid glucuronide derived from Scutellaria barbata and Erigeron breviscapus , exhibits broad pharmacological effects with promising therapeutic potential in treating various chronic diseases. It has demonstrated efficacy modulating multiple biological pathways, including antioxidant, anti-inflammatory, anti-apoptotic, vasodilatory mechanisms. These protective roles make SCU valuable compound diseases such as cerebrovascular diseases, cardiovascular neurodegenerative disorders, metabolic Despite its multi-targeted effects, faces challenges low bioavailability limited clinical data, which hinder widespread application. Current research supports to prevent oxidative stress, reduce inflammatory responses, enhance cell survival cells rats. However, more comprehensive studies are required clarify molecular mechanisms develop strategies that for use. could emerge potent agent the treatment of complex pathophysiological This review examines current literature on provide understanding activity, action,

Language: Английский

Citations

3