Abnormalities of IL-12 Family Cytokine Pathways in Autosomal Dominant Polycystic Kidney Disease Progression DOI Creative Commons
Corina Daniela Ene,

Ilinca Nicolae,

Cristina Căpușă

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1971 - 1971

Published: Nov. 30, 2024

Background and Objectives: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most frequent genetic renal disease with a complex physiopathology. More more studies sustain that inflammation plays crucial role in ADPKD pathogenesis progression. We evaluated IL-12 involvement pathophysiology by assessing serum levels of its monomers heterodimers. Materials Methods: A prospective case-control study was developed included 66 subjects control group 40 healthy subjects. The diagnosis based on familial history clinical imagistic exams. eGFR > 60 mL/min/1.73 mp, no hematuria or other disorders, stable blood pressure last 6 months. tested p40 p35 heterodimers p70, IL-23, IL 35, assessed ELISA method. Results: family programming abnormal patients. IL-12p70, IL-12p40, IL-23 secretion increased, while IL-12p35 IL-35 decreased compared to control. had progressive increase correlated immune response amplification, decrease eGFR, an TKV, albuminuria. On hand, were negatively CRP albuminuria positively advanced ADPKD. Conclusions: present investigated cytokine members’ pathogenesis, enriching our understanding common disorder.

Language: Английский

Advances in sepsis research: Insights into signaling pathways, organ failure, and emerging intervention strategies DOI Creative Commons
Yehua Li, Siying Ren,

Shenao Zhou

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104963 - 104963

Published: March 27, 2025

Language: Английский

Citations

0
Abnormalities of IL-12 Family Cytokine Pathways in Autosomal Dominant Polycystic Kidney Disease Progression DOI Creative Commons
Corina Daniela Ene,

Ilinca Nicolae,

Cristina Căpușă

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1971 - 1971

Published: Nov. 30, 2024

Background and Objectives: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most frequent genetic renal disease with a complex physiopathology. More more studies sustain that inflammation plays crucial role in ADPKD pathogenesis progression. We evaluated IL-12 involvement pathophysiology by assessing serum levels of its monomers heterodimers. Materials Methods: A prospective case-control study was developed included 66 subjects control group 40 healthy subjects. The diagnosis based on familial history clinical imagistic exams. eGFR > 60 mL/min/1.73 mp, no hematuria or other disorders, stable blood pressure last 6 months. tested p40 p35 heterodimers p70, IL-23, IL 35, assessed ELISA method. Results: family programming abnormal patients. IL-12p70, IL-12p40, IL-23 secretion increased, while IL-12p35 IL-35 decreased compared to control. had progressive increase correlated immune response amplification, decrease eGFR, an TKV, albuminuria. On hand, were negatively CRP albuminuria positively advanced ADPKD. Conclusions: present investigated cytokine members’ pathogenesis, enriching our understanding common disorder.

Language: Английский

Citations

0