NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations DOI Creative Commons
Monica Driscoll, Christine A. Sedore, Brian Onken

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

A core facet of the National Institute on Aging's mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part comprehensive effort toward goal, NIA Division Biology Aging established Caenorhabditis Intervention Testing Program (CITP) in 2013. The C. elegans model (with an ~ 21 day lifespan) has led field dissection longevity genetics offers features allow for relatively rapid testing potential elaboration biological mechanisms engaged by candidate geroprotectants. CITP builds this foundation utilizing a genetically diverse set intervention test strains so "subjects" represent genetic diversity akin between mouse humans. Another distinctive aspect dedicated focus reproducibility outcomes as labs at three independent sites confirm positive outcomes. overall goal robust reproducible pro-longevity affecting cohorts genus. strong Data Collection Center supports data collection dissemination. Pharmacological tested be nominated general public, directed in-house screens, or supported published scientific literature. December 2024, > 75 compounds conducted 725,000 animal assays over 891 trials. We identified 12 confer ≥ 20% increase median lifespan reproducibly robustly extend across multiple labs. Five these have impact reported literature (most are not yet mouse). celebration 50th Anniversary NIA, we review development history accomplishments program, comment translation promise advancing understanding fundamental biology includes intervention/health interface.

Language: Английский

NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations DOI Creative Commons
Monica Driscoll, Christine A. Sedore, Brian Onken

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

A core facet of the National Institute on Aging's mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part comprehensive effort toward goal, NIA Division Biology Aging established Caenorhabditis Intervention Testing Program (CITP) in 2013. The C. elegans model (with an ~ 21 day lifespan) has led field dissection longevity genetics offers features allow for relatively rapid testing potential elaboration biological mechanisms engaged by candidate geroprotectants. CITP builds this foundation utilizing a genetically diverse set intervention test strains so "subjects" represent genetic diversity akin between mouse humans. Another distinctive aspect dedicated focus reproducibility outcomes as labs at three independent sites confirm positive outcomes. overall goal robust reproducible pro-longevity affecting cohorts genus. strong Data Collection Center supports data collection dissemination. Pharmacological tested be nominated general public, directed in-house screens, or supported published scientific literature. December 2024, > 75 compounds conducted 725,000 animal assays over 891 trials. We identified 12 confer ≥ 20% increase median lifespan reproducibly robustly extend across multiple labs. Five these have impact reported literature (most are not yet mouse). celebration 50th Anniversary NIA, we review development history accomplishments program, comment translation promise advancing understanding fundamental biology includes intervention/health interface.

Language: Английский

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