“Remodeling the intestinal immune microenvironment”: immune regulation and tissue regeneration by mesenchymal stem/stromal cells in the repair microenvironment of inflammatory bowel disease DOI Creative Commons
Hongkun Li, Yuyue Zhang, Simin Du

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 13, 2025

The global prevalence of inflammatory bowel disease (IBD) has significantly increased in recent decades. IBD is a long-term, recurring, gastrointestinal condition that mainly comprises two primary clinical types: ulcerative colitis and Crohn's disease. current treatment paradigm for primarily focuses on symptom management. However, this approach does not support mucosal epithelial repair, maintenance barrier homeostasis, or regulation biological functions the gut. Conventional therapies rely frequent use high-dose medications, including antibiotics, nonsteroidal anti-inflammatory drugs, agents, immunomodulators. Recently, mesenchymal stem/stromal cells (MSCs) have gained interest tissue regeneration owing to their unique ability differentiate secrete regulatory factors, extracellular vesicles (EVs), which play crucial roles abnormal organization. Various routes administration been explored preclinical studies deliver MSCs from diverse sources. include intraperitoneal, intravenous, local (intracolonic rectal) delivery. employed were obtained various tissues, bone marrow, umbilical cord, adipose tissue. This article reviews research framework application EVs secretion IBD, emphasizing key immunological effects, such as immune microenvironment regulation, intestinal stabilization, therapeutic approaches targeting disorders. discussion advantages over other biologics, impairment gut tissue-resident stem development, targets (at cellular molecular levels) within reparative effects IBD. We aimed present an overview trends MSC therapy, well identify challenges future directions must be addressed advance MSC-mediated strategies

Language: Английский

Mesenchymal stem cells and mesenchymal stem cell-derived exosomes: a promising strategy for treating retinal degenerative diseases DOI Creative Commons

Wenjing An,

Wenliang Zhang, Qi Jia

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Feb. 21, 2025

Abstract Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic strategy in regenerative medicine, demonstrating significant potential for clinical applications. Evidence suggests that MSCs not only exhibit multipotent differentiation but also exert critical effects retinal degenerative diseases via robust paracrine mechanisms. protect from damage by modulating inflammation, inhibiting apoptosis, alleviating oxidative stress, and suppressing cell death pathways. Furthermore, contribute to structural functional stability facilitating vascular remodeling donating mitochondria cells. Of particular interest, MSC-derived exosomes gained widespread attention compelling cell-free therapy. Owing their potent anti-inflammatory, anti-apoptotic, vascular-stabilizing properties, show promise the treatment of diseases.

Language: Английский

Citations

1
“Remodeling the intestinal immune microenvironment”: immune regulation and tissue regeneration by mesenchymal stem/stromal cells in the repair microenvironment of inflammatory bowel disease DOI Creative Commons
Hongkun Li, Yuyue Zhang, Simin Du

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 13, 2025

The global prevalence of inflammatory bowel disease (IBD) has significantly increased in recent decades. IBD is a long-term, recurring, gastrointestinal condition that mainly comprises two primary clinical types: ulcerative colitis and Crohn's disease. current treatment paradigm for primarily focuses on symptom management. However, this approach does not support mucosal epithelial repair, maintenance barrier homeostasis, or regulation biological functions the gut. Conventional therapies rely frequent use high-dose medications, including antibiotics, nonsteroidal anti-inflammatory drugs, agents, immunomodulators. Recently, mesenchymal stem/stromal cells (MSCs) have gained interest tissue regeneration owing to their unique ability differentiate secrete regulatory factors, extracellular vesicles (EVs), which play crucial roles abnormal organization. Various routes administration been explored preclinical studies deliver MSCs from diverse sources. include intraperitoneal, intravenous, local (intracolonic rectal) delivery. employed were obtained various tissues, bone marrow, umbilical cord, adipose tissue. This article reviews research framework application EVs secretion IBD, emphasizing key immunological effects, such as immune microenvironment regulation, intestinal stabilization, therapeutic approaches targeting disorders. discussion advantages over other biologics, impairment gut tissue-resident stem development, targets (at cellular molecular levels) within reparative effects IBD. We aimed present an overview trends MSC therapy, well identify challenges future directions must be addressed advance MSC-mediated strategies

Language: Английский

Citations

0