The Impact of the Exposome on Alzheimer’s Disease: The Influence of Nutrition DOI Open Access

Martina Monaco,

Carola Torazza, Ernesto Fedele

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3015 - 3015

Published: March 26, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative characterized by cognitive decline, memory loss, and behavioural changes. While genetic predispositions pathological processes have been the traditional focus, this review highlights fundamental role of environmental factors, particularly nutrition, within exposome framework in modulating risk progression AD. The exposome, which includes totality exposures an individual's lifetime, provides comprehensive approach to understanding complex aetiology In review, we explore impact dietary factors cyclic nucleotide pathways (cAMP/cGMP) on AD, emphasizing potential interventions as therapeutic strategies. We investigate key aspects how nutrition affects accumulation β-amyloid, aggregation tau proteins, neuroinflammation. also examine specific nutrients performance Additionally, discuss nutraceuticals with anti-phosphodiesterase activity various animal models AD (such 5xFAD, 3xTg-AD, Tg2576, APP/PS1 mice) demonstrating effects onset progression.

Language: Английский

Behavioral and pathological characteristics of 5xFAD female mice in the early stage DOI Creative Commons
Chenlu Zhu, Xuejiao Liu

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

Alzheimer's disease (AD) is a central nervous system degenerative with insidious onset and gradual development caused by selective progressive loss of neurons. The 5xFAD mouse relatively mature model AD. However, the behavioral research on female more focused changes late memory function, exploration its early pathological still incomplete. This aims to explore in emotional function (including anxiety depression), motor ability, amyloid plaques, glial cell response neurogenesis hippocampus mice stage, laying foundation for comprehensive mechanism results this study found that 4-month-old mainly showed decline without other dysfunction. Accompanied large amount protein plaques deposited hippocampus, it induced microglia astrocytes, decreased significantly age, especially mice, which resulted decrease number new may be an important reason stage.

Language: Английский

Citations

0
Humanized rodent models of neurodegenerative diseases and other brain disorders DOI
X.B Zhang, Jianxiang Wang, Jiewen Zhang

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106112 - 106112

Published: March 1, 2025

Language: Английский

Citations

0
The Impact of the Exposome on Alzheimer’s Disease: The Influence of Nutrition DOI Open Access

Martina Monaco,

Carola Torazza, Ernesto Fedele

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3015 - 3015

Published: March 26, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative characterized by cognitive decline, memory loss, and behavioural changes. While genetic predispositions pathological processes have been the traditional focus, this review highlights fundamental role of environmental factors, particularly nutrition, within exposome framework in modulating risk progression AD. The exposome, which includes totality exposures an individual's lifetime, provides comprehensive approach to understanding complex aetiology In review, we explore impact dietary factors cyclic nucleotide pathways (cAMP/cGMP) on AD, emphasizing potential interventions as therapeutic strategies. We investigate key aspects how nutrition affects accumulation β-amyloid, aggregation tau proteins, neuroinflammation. also examine specific nutrients performance Additionally, discuss nutraceuticals with anti-phosphodiesterase activity various animal models AD (such 5xFAD, 3xTg-AD, Tg2576, APP/PS1 mice) demonstrating effects onset progression.

Language: Английский

Citations

0