A Direct Relationship Between ‘Blood Stasis’ and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment DOI Creative Commons
Douglas B. Kell, Etheresia Pretorius, Huihui Zhao

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 712 - 712

Published: May 12, 2025

‘Blood stasis’ (syndrome) (BSS) is a fundamental concept in Traditional Chinese Medicine (TCM), where it known as Xue Yu (血瘀). Similar concepts exist Korean (‘Eohyul’) and Japanese Kampo medicine (Oketsu). Blood stasis considered to underpin large variety of inflammatory diseases, though an exact equivalent Western systems yet be described. Some time ago we discovered that blood can clot into anomalous amyloid form, creating what have referred fibrinaloid microclots. These microclots occur great many chronic, diseases are comparatively resistant fibrinolysis, thus the ability block microcapillaries hence lower oxygen transfer tissues, with multiple pathological consequences. We here develop idea precisely relate to, largely mechanistically responsible for, traditional (a term also used by Virchow). First, associated all stasis. Secondly, blocking red cell transport, provide simple mechanistic explanation for physical slowing down (‘stasis’) flow. Thirdly, herbal formulae proposed treat these especially Fu Zhu its derivatives, anticoagulatory anti-inflammatory, consistent they actually helping levels microclots, plausibly part catalysis polymerization fibrinogen form. rehearse some actions constituent herbs specific bioactive molecules contain. Consequently, such formulations (and their components), which little science medicine, would seem offer opportunity novel, safe, useful treatments chronic display including Myalgic Encephalopathy/Chronic Fatigue Syndrome, long COVID, even ischemic stroke.

Language: Английский

Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature DOI Creative Commons
Sandra Maria Barbalho, Beatriz Leme Boaro,

Jéssica da Silva Camarinha Oliveira

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 133 - 133

Published: Jan. 20, 2025

Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by dysregulation molecular pathways and activation brain’s immune system, resulting release pro-inflammatory oxidative molecules. This chronic inflammation exacerbated peripheral leukocyte infiltration into central nervous system. Medicinal plants, with their historical use traditional medicine, have emerged as promising candidates to mitigate neuroinflammation offer sustainable alternative for addressing conditions green healthcare framework. review evaluates effects medicinal plants on neuroinflammation, emphasizing mechanisms action, effective dosages, clinical implications, based systematic search databases such PubMed, SCOPUS, Web Science. The findings highlight that like Cleistocalyx nervosum var. paniala, Curcuma longa, Cannabis sativa, Dioscorea nipponica reduce cytokines (TNF-α, IL-6, IL-1β), inhibit enzymes (COX-2 iNOS), activate antioxidant pathways, particularly Nrf2. NF-κB primary pathway inhibited across studies. While anti-inflammatory potential these significant, variability dosages phytochemical compositions limits translation. Here, we are modulators underscoring therapeutic potential. Future research should focus animal models, standardized protocols, safety assessments, integrating advanced methodologies, genetic studies nanotechnology, enhance applicability disease management.

Language: Английский

Citations

1
A Direct Relationship Between ‘Blood Stasis’ and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment DOI Creative Commons
Douglas B. Kell, Etheresia Pretorius, Huihui Zhao

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 712 - 712

Published: May 12, 2025

‘Blood stasis’ (syndrome) (BSS) is a fundamental concept in Traditional Chinese Medicine (TCM), where it known as Xue Yu (血瘀). Similar concepts exist Korean (‘Eohyul’) and Japanese Kampo medicine (Oketsu). Blood stasis considered to underpin large variety of inflammatory diseases, though an exact equivalent Western systems yet be described. Some time ago we discovered that blood can clot into anomalous amyloid form, creating what have referred fibrinaloid microclots. These microclots occur great many chronic, diseases are comparatively resistant fibrinolysis, thus the ability block microcapillaries hence lower oxygen transfer tissues, with multiple pathological consequences. We here develop idea precisely relate to, largely mechanistically responsible for, traditional (a term also used by Virchow). First, associated all stasis. Secondly, blocking red cell transport, provide simple mechanistic explanation for physical slowing down (‘stasis’) flow. Thirdly, herbal formulae proposed treat these especially Fu Zhu its derivatives, anticoagulatory anti-inflammatory, consistent they actually helping levels microclots, plausibly part catalysis polymerization fibrinogen form. rehearse some actions constituent herbs specific bioactive molecules contain. Consequently, such formulations (and their components), which little science medicine, would seem offer opportunity novel, safe, useful treatments chronic display including Myalgic Encephalopathy/Chronic Fatigue Syndrome, long COVID, even ischemic stroke.

Language: Английский

Citations

0