A Literature Review of Glutathione Therapy in Ameliorating Hepatic Dysfunction in Non-Alcoholic Fatty Liver Disease

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 644 - 644

Published: March 6, 2025

Non-alcoholic fatty liver disease (NAFLD) is a global cause of dysfunction. This spectrum hepatic disorders can progress to severe conditions, such as non-alcoholic steatohepatitis (NASH) and cirrhosis, due oxidative stress sustained cellular injury. With limited pharmacological options, glutathione (GSH), key antioxidant, has shown promising potential in reducing stress, maintaining redox balance, improving function. literature review examines studies from 2014–2024 exploring GSH therapy NAFLD patients. Eligible assessed the primary intervention for human subjects, reporting outcomes function or markers. Randomized clinical trials (RCTs) were eligible, while combination included if GSH’s effect could be isolated. Exclusions applied non-NAFLD studies, animal/in vitro models, non-GSH antioxidant interventions. Analysis three (totaling 109 participants) demonstrated consistent improvements alanine transaminase (ALT) levels reductions markers like 8-hydroxy-2-deoxyguanosine (8-OHdG). However, small sample sizes inconsistent protocols limit generalizability. Further large-scale RCTs are required confirm efficacy, determine optimal dosing, assess long-term effects. highlights novel therapeutic strategy emphasizing need further refine its application.

Language: Английский

The mechanism study of quercetin isolated from Zanthoxylum bungeanum maxim. inhibiting ferroptosis and alleviating MAFLD through p38 MAPK/ERK signaling pathway based on lipidomics and transcriptomics

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 31, 2025

As a resource with variety of medicinal and edible values, Zanthoxylum bungeanum Maxim has been found to improve high-fat diet-induced metabolic-associated fatty liver disease (MAFLD). The aim this study was predict the main active metabolites in Z. Maxim. Based on network analysis, explore validate their potential mechanisms action through lipidomics transcriptomic techniques. MAFLD mouse model cell were established evaluate effect components MAFLD. Serum biochemical indexes, pathological staining observation, lipid group transcriptome used verify mechanism Quercetin can regulate mice Glycerophospholipid metabolic pathway, thereby improving accumulation injury. At same time, quercetin also by reducing oleic acid-induced HepG2 cells, inhibit ferroptosis p38 MAPK/ERK signaling alleviating progression isolated from ameliorative effects MAFLD, probably mainly affecting pathways MAPK pathways.

Language: Английский