Molecular Mechanism of Phytochemical Compounds in Mitigating Hypertension DOI Creative Commons
Putri Cahaya Situmorang, Syahputra Wibowo,

Masitta Tanjung

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100812 - 100812

Published: May 1, 2025

Language: Английский

Protective effects and mechanisms of quercetin in animal models of hyperuricemia: A systematic review and meta-analysis DOI Creative Commons

Xueren Bian,

Z. K. Ge,

Xu-Shan Chen

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107665 - 107665

Published: Feb. 1, 2025

Quercetin, a prevalent natural flavonoid found in various medicinal plants, including Dendrobium officinale Kimura & Migo, has garnered attention for its potential health benefits. However, foundational animal studies investigating the effects of quercetin on lowering uric acid levels remain insufficiently established, and number related clinical is limited. This scarcity hinders practical application managing hyperuricemia. We systematically searched preclinical published by December 2024 nine databases, such as PubMed, Web Science, Embase. The results our meta-analysis showed that, compared with model group, not only effectively alleviated pathological injury kidney liver improved renal function indexes hyperuricemia but also played role modulating multiple signaling pathways oxidative stress, lipid metabolism, transporter proteins. Quercetin more substantial effect decreasing serum creatinine (SMD = -4.29, 95% CI [-6.48, -2.10], P 0.0001), blood urea nitrogen -3.08, [-4.80, -1.35], 0.0005), Up-regulate organic anion 1 mRNA expression 2.72, 95%CI [0.45, 4.99], 0.02) to positive control group. Sensitivity analyses confirmed stability results, while subgroup analysis indicates that treatment course may be main source heterogeneity. Dose-efficacy suggested had protective against at gavage dose 100 - 200mg/kg. accurately assess hyperuricemia, it essential conduct additional high-quality, large-scale trials validate findings.

Language: Английский

Citations

1
Exploring quercetin based nano formulation in combating human Metapneumovirus infections DOI
V. Bhuvaneshwari,

Ramasamy Amsaveni

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114510 - 114510

Published: March 24, 2025

Language: Английский

Citations

0
Effect of Resveratrol and Quercetin on SFRP4 as a Biomarker of Diabesity: In Silico and In Vivo Studies DOI
Asim Rehman, Shazia Anwer Bukhari, Zunera Chauhdary

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151748 - 151748

Published: April 1, 2025

Language: Английский

Citations

0
Targeting ferroptosis: a novel pathway in oral, oropharyngeal, hypopharyngeal, and laryngeal cancers DOI

Anis Elhami,

Shabnam Ghasemzadeh,

Sahand Emrahoglu

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

Citations

0
Quercetin-loaded PEGylated liposomes alleviate testicular dysfunction in alloxan-induced diabetic rats: The role of Kisspeptin/Neurokinin B/Dynorphin pathway DOI

Mohamed Fouad Mansour,

Amany Behairy,

Mahmoud Mostafa

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117337 - 117337

Published: April 1, 2025

Language: Английский

Citations

0
Investigating the potential compounds of Kalanchoe pinnata plant for the treatment of Inflammation utilizing molecular docking and molecular dynamic simulation approach DOI Creative Commons

S. M. Istiaque Hamim,

Miah Roney, Md. Nazim Uddin

et al.

Published: April 1, 2025

Language: Английский

Citations

0
Enhanced hepatoprotective efficacy of quercetin nanoparticles versus free quercetin against acrylamide-induced hepatotoxicity through modulation of MAPK/NF-κB/NLRP3 signaling pathways and molecular docking validation DOI

Rasha Atta,

Horeya Erfan Korayem Arafat, Islam A. Khalil

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102936 - 102936

Published: April 25, 2025

Language: Английский

Citations

0
Comparative profiling of secondary metabolites and antidiabetic properties of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) extracts DOI
Ikponmwosa Owen Evbuomwan,

Emmanuel Henry Ezenabor,

Aishat Abimbola Adeyemi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Background: Diabetes mellitus is a chronic metabolic condition which can result in severe long-term complications, and current treatments often have significant side effects. As result, there growing interest identifying novel α-amylase α-glucosidase inhibitors with improved safety profiles. Natural products emerged as promising source of such compounds. In this study, we investigated the antidiabetic potential solvent extracts phenolic compounds from Anogeissus leiocarpus (DC.) Guill. & Perr. Methods: Dried leaves stem bark were extracted using aqueous absolute ethanol, yielding ALE, ASE, ELE, ESE. We assessed their TPC, TFC, antioxidant capacity. The efficacy these HPLC-identified was evaluated through in vitro computational analyses inhibition. Results: ASE ALE demonstrated high polyphenol flavonoid content, along strong dose-dependent activity (FRAC, TAC, DPPH, NO scavenging). ASE highest inhibition, comparable to metformin (p > 0.05). Molecular docking analysis showed interactions between both α-glucosidase, binding affinities metformin. Notably, rutin exhibited scores -7.736 -7.098 kcal/mol for respectively, outperforming (-4.305 -4.094 kcal/mol). Conclusion: These findings suggest that A. its hold promise potent safer diabetes treatment.

Language: Английский

Citations

0
Unlocking the Pharmacological Potential of Myricetin Against Various Pathogenesis DOI Open Access
Saleh A. Almatroodi, Arshad Husain Rahmani

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4188 - 4188

Published: April 28, 2025

Myricetin is a natural flavonoid with powerful antioxidant and anti-inflammatory potential commonly found in vegetables, fruits, nuts, tea. The vital role of this the prevention treatment various diseases evidenced by its ability to reduce inflammation oxidative stress, maintain tissue architecture, modulate cell signaling pathways. Thus, review summarizes recent evidence on myricetin, focusing precisely mechanisms action pathogenesis, including obesity, diabetes mellitus, arthritis, osteoporosis, liver, neuro, cardio, reproductive system-associated pathogenesis. Moreover, it has been revealed that myricetin exhibits anti-microbial properties due obstructive virulence factors, preventing biofilm formation disrupting membrane integrity. Additionally, synergistic other drugs myricetin-based nanoformulations different are properly discussed. This seeks increase understanding myricetin’s pharmacological diseases, principally highlighting effective action. Further wide-ranging research, as well more randomized controlled clinical trial studies, should be executed reconnoiter compound’s therapeutic value, safety, usefulness against human

Language: Английский

Citations

0
Development and Characterization of Chitosan Nanoparticles Containing Quercetin-β-Cyclodextrin Inclusion Complex for Improved Solubility, Brain Targeting, and Neuroprotective Potential Against Epilepsy DOI
Priyabrata Pradhan, Vineet Kumar, Jitu Halder

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(5)

Published: May 6, 2025

Language: Английский

Citations

0